ventricular cardiac muscle tissue development

Definition

Target type: biologicalprocess

The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure. [GOC:mtg_heart]

Ventricular cardiac muscle tissue development is a complex and highly regulated process that begins during embryogenesis and continues throughout postnatal life. It involves a series of intricate molecular and cellular events that orchestrate the formation of a functional and contractile heart chamber.

The process starts with the specification of the cardiac progenitor cells, a population of pluripotent cells within the developing embryo. These progenitor cells migrate to the heart field, a specific region of the embryo where the heart will form, and differentiate into various cardiac cell types, including cardiomyocytes, the contractile cells of the heart.

Cardiomyocytes undergo a series of coordinated events to develop their characteristic structure and function. They elongate, align, and connect with each other via specialized junctions called intercalated discs. These junctions provide structural integrity and facilitate the synchronized contraction of cardiomyocytes, allowing the heart to pump blood effectively.

As cardiomyocytes mature, they acquire a specific arrangement, forming the complex structure of the ventricle. This structure, with its intricate network of chambers, valves, and vessels, is essential for the efficient pumping of blood throughout the body.

The development of ventricular cardiac muscle tissue is influenced by a wide range of signaling molecules, including growth factors, transcription factors, and microRNAs. These molecules act in a coordinated manner to control the proliferation, differentiation, and maturation of cardiomyocytes, ensuring the formation of a functional heart chamber.

Throughout postnatal life, ventricular cardiac muscle tissue undergoes a process of continuous remodeling, adapting to changes in physiological demands and responding to injuries. This remodeling involves the addition of new cardiomyocytes, the growth of existing cardiomyocytes, and the re-organization of the extracellular matrix, the scaffold that supports the heart muscle.

In summary, ventricular cardiac muscle tissue development is a multi-step process that involves the specification, differentiation, maturation, and remodeling of cardiomyocytes. This process is tightly regulated by a complex interplay of signaling molecules and is essential for the formation and maintenance of a functional heart chamber.'
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Proteins (2)

Compounds (17)