Page last updated: 2024-08-07 10:27:35

Transient receptor potential cation channel subfamily M member 4

A transient receptor potential cation channel subfamily M member 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TD43]

Synonyms

hTRPM4;
Calcium-activated non-selective cation channel 1;
Long transient receptor potential channel 4;
LTrpC-4;
LTrpC4;
Melastatin-4

Research

Bioassay Publications (1)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (100.00)24.3611
2020's0 (0.00)2.80

Compounds (1)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
9-phenanthrolHomo sapiens (human)IC5029.000011

Enables

This protein enables 7 target(s):

TargetCategoryDefinition
calcium-activated cation channel activitymolecular functionEnables the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient. [GOC:dph, GOC:mtg_transport]
sodium channel activitymolecular functionEnables the facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
calcium ion bindingmolecular functionBinding to a calcium ion (Ca2+). [GOC:ai]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
calmodulin bindingmolecular functionBinding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. [GOC:krc]
ATP bindingmolecular functionBinding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
ligand-gated calcium channel activitymolecular functionEnables the transmembrane transfer of a calcium ions by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. [GOC:dos]

Located In

This protein is located in 7 target(s):

TargetCategoryDefinition
nucleoplasmcellular componentThat part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
endoplasmic reticulumcellular componentThe irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]
Golgi apparatuscellular componentA membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. [ISBN:0198506732]
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
membranecellular componentA lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
neuronal cell bodycellular componentThe portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. [GOC:go_curators]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Part Of

This protein is part of 1 target(s):

TargetCategoryDefinition
sodium channel complexcellular componentAn ion channel complex through which sodium ions pass. [GOC:mah]

Involved In

This protein is involved in 27 target(s):

TargetCategoryDefinition
adaptive immune responsebiological processAn immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory). [GO_REF:0000022, GOC:add, ISBN:0781735149]
dendritic cell chemotaxisbiological processThe movement of a dendritic cell in response to an external stimulus. [CL:0000451, GOC:add, ISBN:0781735149, PMID:15814331, PMID:16056255]
regulation of T cell cytokine productionbiological processAny process that modulates the frequency, rate, or extent of T cell cytokine production. [GOC:add]
positive regulation of cytosolic calcium ion concentrationbiological processAny process that increases the concentration of calcium ions in the cytosol. [GOC:ai]
positive regulation of cell population proliferationbiological processAny process that activates or increases the rate or extent of cell proliferation. [GOC:go_curators]
positive regulation of heart ratebiological processAny process that activates or increases the frequency or rate of heart contraction. [GOC:dph, GOC:tb]
protein sumoylationbiological processThe process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein. [GOC:jl, PMID:11265250]
calcium-mediated signalingbiological processAny intracellular signal transduction in which the signal is passed on within the cell via calcium ions. [GOC:signaling]
negative regulation of bone mineralizationbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of bone mineralization. [GOC:go_curators]
positive regulation of insulin secretion involved in cellular response to glucose stimulusbiological processAny process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. [GOC:bf, GOC:yaf]
positive regulation of fat cell differentiationbiological processAny process that activates or increases the frequency, rate or extent of adipocyte differentiation. [GOC:go_curators]
negative regulation of osteoblast differentiationbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of osteoblast differentiation. [GOC:go_curators]
positive regulation of vasoconstrictionbiological processAny process that activates or increases the frequency, rate or extent of vasoconstriction. [GOC:go_curators]
protein homotetramerizationbiological processThe formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits. [GOC:go_curators]
calcium ion transmembrane transportbiological processA process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:mah]
cellular response to ATPbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus. [GOC:mah]
membrane depolarization during AV node cell action potentialbiological processThe process in which AV node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
membrane depolarization during Purkinje myocyte cell action potentialbiological processThe process in which Purkinje myocyte membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
membrane depolarization during bundle of His cell action potentialbiological processThe process in which bundle of His cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
regulation of heart rate by cardiac conductionbiological processA cardiac conduction process that modulates the frequency or rate of heart contraction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
positive regulation of canonical Wnt signaling pathwaybiological processAny process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. [GOC:tb]
inorganic cation transmembrane transportbiological processA process in which an inorganic cation is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:mah]
sodium ion import across plasma membranebiological processThe directed movement of sodium ions from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos]
regulation of ventricular cardiac muscle cell action potentialbiological processAny process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a ventricular cardiac muscle cell contributing to the regulation of its contraction. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
positive regulation of atrial cardiac muscle cell action potentialbiological processAny process that activates or increases the frequency, rate or extent of atrial cardiac muscle cell action potential. [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747]
positive regulation of adipose tissue developmentbiological processAny process that activates or increases the frequency, rate or extent of adipose tissue development. [GO_REF:0000058, GOC:TermGenie, PMID:23081848]
positive regulation of regulation of vascular associated smooth muscle cell membrane depolarizationbiological processAny process that activates or increases the frequency, rate or extent of regulation of vascular smooth muscle cell membrane depolarization. [GO_REF:0000058, GOC:TermGenie, PMID:20826763]