4-methylnicotinamide profile

4-Methylnicotinamide, also known as N1-methyl-4-pyridinecarboxamide, is a derivative of nicotinamide. It is a naturally occurring compound found in various plants and microorganisms. Research suggests it might have various biological activities, including potential antioxidant and anti-inflammatory properties. It is of interest for its potential therapeutic applications, particularly in the context of neurodegenerative diseases and cancer. However, further research is needed to fully understand its mechanisms of action and its potential clinical benefits. '

4-methylnicotinamide: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	95692
CHEMBL ID	1501622
SCHEMBL ID	1265706
MeSH ID	M0175654

Synonym
4-methylnicotinamide
7250-52-4
mls000737610 ,
nsc-30041
nsc30041
smr000393781
4-methylpyridine-3-carboxamide
AKOS004907409
NCGC00246926-01
bdbm50389436
nsc 30041
3-pyridinecarboxamide, 4-methyl-
4-methyl-3-pyridinecarboxamide
CHEMBL1501622 ,
HMS2748O15
DTXSID90222815
SCHEMBL1265706
mfcd00234322
TS-01752
(2-butyl-1-benzofuran-3-yl)-[4-(2-ethylaminoethoxy)-3,5-diiodophenyl]methanone
3-pyridinecarboxamide,4-methyl-(9ci)
FT-0713376
AMY33286
CS-0061336
SB53849

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	Homo sapiens (human)	Potency	0.1000	0.0040	23.8416	100.0000	AID485290
IDH1	Homo sapiens (human)	Potency	29.0929	0.0052	10.8652	35.4813	AID686970
euchromatic histone-lysine N-methyltransferase 2	Homo sapiens (human)	Potency	50.1187	0.0355	20.9770	89.1251	AID504332
Guanine nucleotide-binding protein G	Homo sapiens (human)	Potency	39.8107	1.9953	25.5327	50.1187	AID624287
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	Homo sapiens (human)	IC50 (µMol)	23.0000	0.8500	5.4300	10.0000	AID674941
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
negative regulation of inflammatory response to antigenic stimulus	Guanine nucleotide-binding protein G	Homo sapiens (human)
renal water homeostasis	Guanine nucleotide-binding protein G	Homo sapiens (human)
G protein-coupled receptor signaling pathway	Guanine nucleotide-binding protein G	Homo sapiens (human)
regulation of insulin secretion	Guanine nucleotide-binding protein G	Homo sapiens (human)
cellular response to glucagon stimulus	Guanine nucleotide-binding protein G	Homo sapiens (human)
chromatin remodeling	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	Homo sapiens (human)
protein deacetylation	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	Homo sapiens (human)
aerobic respiration	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	Homo sapiens (human)
positive regulation of insulin secretion	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	Homo sapiens (human)
peptidyl-lysine deacetylation	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	Homo sapiens (human)
negative regulation of ERK1 and ERK2 cascade	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	Homo sapiens (human)
positive regulation of superoxide dismutase activity	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	Homo sapiens (human)
positive regulation of catalase activity	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	Homo sapiens (human)
positive regulation of ceramide biosynthetic process	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	Homo sapiens (human)
negative regulation of reactive oxygen species metabolic process	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
G protein activity	Guanine nucleotide-binding protein G	Homo sapiens (human)
adenylate cyclase activator activity	Guanine nucleotide-binding protein G	Homo sapiens (human)
NAD+ ADP-ribosyltransferase activity	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	Homo sapiens (human)
NAD+-protein ADP-ribosyltransferase activity	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	Homo sapiens (human)
protein binding	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	Homo sapiens (human)
zinc ion binding	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	Homo sapiens (human)
enzyme binding	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	Homo sapiens (human)
NAD-dependent protein lysine deacetylase activity	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	Homo sapiens (human)
sequence-specific DNA binding	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	Homo sapiens (human)
NAD+ binding	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	Homo sapiens (human)
NAD-dependent histone deacetylase activity	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
plasma membrane	Guanine nucleotide-binding protein G	Homo sapiens (human)
nucleoplasm	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	Homo sapiens (human)
mitochondrion	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	Homo sapiens (human)
mitochondrial matrix	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	Homo sapiens (human)
protein-containing complex	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	Homo sapiens (human)
nucleus	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (21)

Assay ID	Title	Year	Journal	Article
AID504810	Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504812	Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1745845	Primary qHTS for Inhibitors of ATXN expression
AID651635	Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID674935	Inhibition of human SIRT3 expressed in Escherichia coli assessed as enzyme activity using Z-MAL as substrate at 1 mM after 6 hrs by fluorescence assay	2012	European journal of medicinal chemistry, Sep, Volume: 55	Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2.
AID674939	Inhibition of human SIRT1 assessed as enzyme activity using Fluor-de-Lys as substrate at 100 uM by fluorometry	2012	European journal of medicinal chemistry, Sep, Volume: 55	Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2.
AID674937	Inhibition of human SIRT2 assessed as enzyme activity using Fluor-de-Lys as substrate at 1 mM by fluorometry	2012	European journal of medicinal chemistry, Sep, Volume: 55	Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2.
AID674938	Inhibition of human SIRT3 expressed in Escherichia coli assessed as enzyme activity using Z-MAL as substrate at 100 uM after 6 hrs by fluorescence assay	2012	European journal of medicinal chemistry, Sep, Volume: 55	Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2.
AID674941	Inhibition of human SIRT3 expressed in Escherichia coli using Z-MAL as substrate after 6 hrs by fluorescence assay	2012	European journal of medicinal chemistry, Sep, Volume: 55	Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2.
AID674940	Inhibition of human SIRT2 assessed as enzyme activity using Fluor-de-Lys as substrate at 100 uM by fluorometry	2012	European journal of medicinal chemistry, Sep, Volume: 55	Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2.
AID674943	Ratio of nicotinamide IC50 to compound IC50 for human SIRT3 expressed in Escherichia coli	2012	European journal of medicinal chemistry, Sep, Volume: 55	Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2.
AID674936	Inhibition of human SIRT1 assessed as enzyme activity using Fluor-de-Lys as substrate at 1 mM by fluorometry	2012	European journal of medicinal chemistry, Sep, Volume: 55	Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (12.50)	18.7374
1990's	1 (12.50)	18.2507
2000's	1 (12.50)	29.6817
2010's	4 (50.00)	24.3611
2020's	1 (12.50)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	8 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
niacinamide nicotinamide : A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.	2.69	3	pyridine alkaloid; pyridinecarboxamide; vitamin B3	anti-inflammatory agent; antioxidant; cofactor; EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor; EC 3.5.1.98 (histone deacetylase) inhibitor; Escherichia coli metabolite; geroprotector; human urinary metabolite; metabolite; mouse metabolite; neuroprotective agent; Saccharomyces cerevisiae metabolite; Sir2 inhibitor
suramin Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.. suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.	2.07	1	naphthalenesulfonic acid; phenylureas; secondary carboxamide	angiogenesis inhibitor; antinematodal drug; antineoplastic agent; apoptosis inhibitor; EC 2.7.11.13 (protein kinase C) inhibitor; GABA antagonist; GABA-gated chloride channel antagonist; purinergic receptor P2 antagonist; ryanodine receptor agonist; trypanocidal drug
s-adenosylmethionine (R)-S-adenosyl-L-methionine : An S-adenosyl-L-methionine that has R-configuration.. S-adenosyl-L-methionine zwitterion : A zwitterionic tautomer of S-adenosyl-L-methionine arising from shift of the proton from the carboxy group to the amino group.. (R)-S-adenosyl-L-methionine zwitterion : An S-adenosyl-L-methionine zwitterion that has R-configuration; major species at pH 7.3.. (S)-S-adenosyl-L-methionine zwitterion : An S-adenosyl-L-methionine zwitterion that has S-configuration; major species at pH 7.3.. S-adenosyl-L-methionine : A sulfonium compound that is the S-adenosyl derivative of L-methionine. It is an intermediate in the metabolic pathway of methionine.	1.98	1	organic cation; sulfonium compound	coenzyme; cofactor; human metabolite; micronutrient; Mycoplasma genitalium metabolite; nutraceutical; Saccharomyces cerevisiae metabolite

Condition	Relationship Strength	Studies
Innate Inflammatory Response [description not available]	2.05	1
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	2.05	1
Aging The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.	1.98	1

4-methylnicotinamide

Description

Cross-References

Synonyms (25)

Protein Targets (5)

Potency Measurements

Inhibition Measurements

Biological Processes (15)

Molecular Functions (11)

Ceullar Components (6)

Bioassays (21)

Research

Studies (8)

Market Indicators

Research Demand Index: 12.59

Study Types

4-methylnicotinamide

Description

Cross-References

Synonyms (25)

Protein Targets (5)

Potency Measurements

Inhibition Measurements

Biological Processes (15)

Molecular Functions (11)

Ceullar Components (6)

Bioassays (21)

Research

Studies (8)

Market Indicators

Research Demand Index: 12.59

Study Types

Related Drugs (3)

Related Conditions (3)