1-(4-chloro-3-methoxyphenyl)sulfonylazepane

**1-(4-Chloro-3-methoxyphenyl)sulfonylazepane** is a chemical compound with the following structure:

```
Cl
|
C
/ \\
O CH3
| |
-S- N
| \\
O (CH2)6
|
C
```

**Importance in Research:**

This compound, also known as **AZD8931**, is a potent and selective **inhibitor of the enzyme dipeptidyl peptidase-4 (DPP-4)**.

**DPP-4** is an enzyme involved in the breakdown of incretin hormones, such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). These incretins play a crucial role in regulating blood glucose levels by stimulating insulin secretion and suppressing glucagon release.

**Inhibiting DPP-4** with compounds like 1-(4-Chloro-3-methoxyphenyl)sulfonylazepane can lead to increased levels of incretins in the body, resulting in improved glycemic control.

**Research Significance:**

1-(4-Chloro-3-methoxyphenyl)sulfonylazepane has been extensively studied in preclinical and clinical trials for its potential therapeutic application in the treatment of **type 2 diabetes**.

**Clinical trials have demonstrated that this compound:**

* **Improves glycemic control** in patients with type 2 diabetes.
* **Reduces HbA1c levels**, a measure of long-term blood glucose control.
* **May have a favorable safety profile** compared to other antidiabetic agents.

**Other Research Areas:**

1-(4-Chloro-3-methoxyphenyl)sulfonylazepane has also been investigated for its potential use in other areas of research, including:

* **Obesity:** It has shown some efficacy in reducing body weight and improving metabolic parameters in preclinical studies.
* **Neurodegenerative diseases:** Its ability to modulate incretin signaling pathways may have therapeutic implications in conditions like Alzheimer's disease.

**Note:**

1-(4-Chloro-3-methoxyphenyl)sulfonylazepane is currently not marketed as a drug. However, its research significance highlights the potential of DPP-4 inhibitors as therapeutic agents for diabetes and other related conditions.