Page last updated: 2024-10-06

validamycin biosynthesis

Proteins (9)

ProteinSynonymsTaxonomy
2-epi-5-epi-valiolone synthaseEEVS; EC 4.2.3.152; Sedoheptulose 7-phosphate cyclaseStreptomyces hygroscopicus subsp. jinggangensis 5008
Validoxylamine A 7'-phosphate phosphataseEC 3.1.3.101; Phosphomutase
Validamine 7-phosphate valienyltransferaseEC 2.5.1.135; Pseudoglycosyltransferase; Trehalose 6-phosphate synthase-like enzyme VldE
Valienol-1-phosphate guanylyltransferaseEC 2.7.7.91; Cyclitol nucleotidyltransferase
Validamycin A dioxygenaseEC 1.14.11.52; Alpha-ketoglutarate/Fe(II)-dependent dioxygenase VldW; Validamycin B synthase
C(7)-cyclitol 7-kinaseEC 2.7.1.214Streptomyces hygroscopicus subsp. jinggangensis 5008
Aminotransferase
ValD
CyclitolreductaseStreptomyces hygroscopicus subsp. jinggangensis 5008

Compounds (21)

CompoundDescription
diphosphoric acid
hydronium ion
CobaltA trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.
Succinate
uridine diphosphateA uracil nucleotide containing a pyrophosphate group esterified to C5 of the sugar moiety.
NADH
ironA metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
Orthophosphate
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
MagnesiumA metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
validoxylamine Afungicide against sheath blight of rice plants; structure given in first source
valienoneisolated from Streptomyces sp.; structure in first source
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
alpha-Ketoglutarate
glutamate
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
validamycin A
5-epi-(6-(2)H2)valiolonestructure in first source