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ergothioneine biosynthesis I (bacteria)

Proteins (5)

ProteinSynonymsTaxonomy
Histidine N-alpha-methyltransferaseEC 2.1.1.44; Histidine trimethyltransferaseMycolicibacterium smegmatis MC2 155
Gamma-glutamyl-hercynylcysteine sulfoxide hydrolaseEC 3.5.1.118; Gamma-glutamyl hercynylcysteine S-oxide hydrolaseMycolicibacterium smegmatis MC2 155
Hercynine oxygenaseEC 1.14.99.50; Gamma-glutamyl hercynylcysteine S-oxide synthaseMycolicibacterium smegmatis MC2 155
Probable hercynylcysteine sulfoxide lyaseEC 4.4.-.-Mycolicibacterium smegmatis MC2 155
Glutamate--cysteine ligase EgtAEC 6.3.2.2; Gamma-glutamylcysteine synthetase; GCS; Gamma-ECSMycolicibacterium smegmatis MC2 155

Compounds (14)

CompoundDescription
hydronium ion
Ammonium
ironA metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
Orthophosphate
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
Pyruvic AcidAn intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
ergothioneineA naturally occurring metabolite of HISTIDINE that has antioxidant properties.
hercyninestructure
glutamate
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
CysteineA thiol-containing non-essential amino acid that is oxidized to form CYSTINE.
s-adenosylmethioninePhysiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)