Page last updated: 2024-10-06

bile acid biosynthesis, neutral pathway

Proteins (6)

ProteinSynonymsTaxonomy
Cytochrome P450 7A124-hydroxycholesterol 7-alpha-hydroxylase; 1.14.14.26; CYPVII; Cholesterol 7-alpha-hydroxylase; Cholesterol 7-alpha-monooxygenase; 1.14.14.23Mus musculus (house mouse)
Vitamin D 25-hydroxylaseEC 1.14.14.24; Cytochrome P450 2R1Mus musculus (house mouse)
Bile acid-CoA:amino acid N-acyltransferaseBACAT; BAT; EC 2.3.1.65; Bile acid-CoA thioesterase; Choloyl-CoA hydrolase; 3.1.2.27; Glycine N-choloyltransferase; Long-chain fatty-acyl-CoA hydrolase; 3.1.2.2Mus musculus (house mouse)
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylaseEC 1.14.18.8; 7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase; CYPVIIIB1; Cytochrome P450 8B1; Sterol 12-alpha-hydroxylaseMus musculus (house mouse)
Sterol carrier protein 2SCP-2; Acetyl-CoA C-myristoyltransferase; 2.3.1.155; Non-specific lipid-transfer protein; NSL-TP; Propanoyl-CoA C-acyltransferase; 2.3.1.176; SCP-2/3-oxoacyl-CoA thiolase; SCP-2/thiolase; 2.3.1.16; SCP-chi; Sterol carrier protein X; SCP-X; Straight-chain Mus musculus (house mouse)
Sterol 26-hydroxylase, mitochondrialEC 1.14.15.15; 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 26-hydroxylase; Cytochrome P-450C27/25; Cytochrome P450 27; Sterol 27-hydroxylase; Vitamin D(3) 25-hydroxylaseMus musculus (house mouse)

Compounds (18)

CompoundDescription
diphosphoric acid
hydronium ion
Adenosine TriphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
7 alpha-hydroxy-4-cholesten-3-onestructure
adenosine monophosphateAdenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
3,7,12-trihydroxycoprostaneintermediate in bile acid synthesis in liver; enhances rate of porphyrin synthesis in cultured liver cells by induction of delta-aminolevulinic acid synthetase; RN given refers to (3alpha,5beta,7alpha,12alpha)-isomer; structure
cholestane-3,7,12,26-tetrolprecursor of cholic acid biosyn in man; RN given refers to (3alpha,5beta,7alpha,12alpha)-isomer
dihydroxycoprostaneintermediate in bile acid synthesis in the liver; enhance rate of prophyrin synthesis in cultured liver cells by induction of delta-aminolevulinic acid synthetase; RN given refers to (3alpha,5beta,7alpha)-isomer; structure
cholestane-3,7,26-triol
Glycine Chenodeoxycholate
Taurine Chenodeoxycholate
cholest-5-en-3 beta,7 alpha-diolsubstrate for hydroxysteroid dehydrogenase; RN given refers to (3beta,7alpha)-isomer
Coenzyme A