Page last updated: 2024-10-06

Thyroxine biosynthesis

Proteins (8)

ProteinSynonymsTaxonomy
Glycoprotein hormones alpha chainAnterior pituitary glycoprotein hormones common subunit alpha; Choriogonadotropin alpha chain; Chorionic gonadotrophin subunit alpha; CG-alpha; Follicle-stimulating hormone alpha chain; FSH-alpha; Follitropin alpha chain; Luteinizing hormone alpha chain; Homo sapiens (human)
Thyroid peroxidaseTPO; EC 1.11.1.8Homo sapiens (human)
Iodotyrosine deiodinase 1IYD-1; EC 1.21.1.1; Iodotyrosine dehalogenase 1Homo sapiens (human)
Thyroxine 5-deiodinaseEC 1.21.99.3; 5DIII; DIOIII; Type 3 DI; Type III iodothyronine deiodinaseHomo sapiens (human)
Sodium/iodide cotransporterNa(+)/I(-) cotransporter; Sodium-iodide symporter; Na(+)/I(-) symporter; Solute carrier family 5 member 5Homo sapiens (human)
Type I iodothyronine deiodinaseEC 1.21.99.4; 5DI; DIOI; Type 1 DI; Type-I 5'-deiodinaseHomo sapiens (human)
Type II iodothyronine deiodinaseEC 1.21.99.4; 5DII; DIOII; Type 2 DI; Type-II 5'-deiodinaseHomo sapiens (human)
Thyrotropin subunit betaThyroid-stimulating hormone subunit beta; TSH-B; TSH-beta; Thyrotropin beta chainHomo sapiens (human)

Compounds (14)

CompoundDescription
hydronium ion
hydroiodic acid
iodineA nonmetallic element of the halogen group that is represented by the atomic symbol I, atomic number 53, and atomic weight of 126.90. It is a nutritionally essential element, especially important in thyroid hormone synthesis. In solution, it has anti-infective properties and is used topically.
Flavin MononucleotideA coenzyme for a number of oxidative enzymes including NADH DEHYDROGENASE. It is the principal form in which RIBOFLAVIN is found in cells and tissues.
thyroxineThe major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
Hydrogen PeroxideA strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
iodineA nonmetallic element of the halogen group that is represented by the atomic symbol I, atomic number 53, and atomic weight of 126.90. It is a nutritionally essential element, especially important in thyroid hormone synthesis. In solution, it has anti-infective properties and is used topically.
SodiumA member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
monoiodotyrosineA product from the iodination of tyrosine. In the biosynthesis of thyroid hormones (THYROXINE and TRIIODOTHYRONINE), tyrosine is first iodized to monoiodotyrosine.
creolinfrom refined coal tar oils