Page last updated: 2024-10-06

TNF signaling

Proteins (36)

ProteinSynonymsTaxonomy
Inhibitor of nuclear factor kappa-B kinase subunit betaI-kappa-B-kinase beta; IKK-B; IKK-beta; IkBKB; EC 2.7.11.10; I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB; Serine/threonine protein kinase IKBKB; 2.7.11.1Homo sapiens (human)
Inhibitor of nuclear factor kappa-B kinase subunit alphaI-kappa-B kinase alpha; IKK-A; IKK-alpha; IkBKA; IkappaB kinase; EC 2.7.11.10; Conserved helix-loop-helix ubiquitous kinase; I-kappa-B kinase 1; IKK1; Nuclear factor NF-kappa-B inhibitor kinase alpha; NFKBIKA; Transcription factor 16; TCF-16Homo sapiens (human)
MAP kinase-activated protein kinase 2MAPK-activated protein kinase 2; MAPKAP kinase 2; MAPKAP-K2; MAPKAPK-2; MK-2; MK2; EC 2.7.11.1Homo sapiens (human)
Disintegrin and metalloproteinase domain-containing protein 17ADAM 17; EC 3.4.24.86; Snake venom-like protease; TNF-alpha convertase; TNF-alpha-converting enzymeHomo sapiens (human)
Caspase-8CASP-8; EC 3.4.22.61; Apoptotic cysteine protease; Apoptotic protease Mch-5; CAP4; FADD-homologous ICE/ced-3-like protease; FADD-like ICE; FLICE; ICE-like apoptotic protease 5; MORT1-associated ced-3 homolog; MACHHomo sapiens (human)
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1Mitogen-activated protein kinase kinase kinase 7-interacting protein 1; TGF-beta-activated kinase 1-binding protein 1; TAK1-binding protein 1Homo sapiens (human)
Tumor necrosis factor alpha-induced protein 3TNF alpha-induced protein 3; EC 2.3.2.-; EC 3.4.19.12; OTU domain-containing protein 7C; Putative DNA-binding protein A20; Zinc finger protein A20Homo sapiens (human)
Ubiquitin carboxyl-terminal hydrolase CYLDEC 3.4.19.12; Deubiquitinating enzyme CYLD; Ubiquitin thioesterase CYLD; Ubiquitin-specific-processing protease CYLDHomo sapiens (human)
Mitogen-activated protein kinase kinase kinase 7EC 2.7.11.25; Transforming growth factor-beta-activated kinase 1; TGF-beta-activated kinase 1Homo sapiens (human)
Serine/threonine-protein kinase ULK1EC 2.7.11.1; Autophagy-related protein 1 homolog; ATG1; hATG1; Unc-51-like kinase 1Homo sapiens (human)
Receptor-interacting serine/threonine-protein kinase 1EC 2.7.11.1; Cell death protein RIP; Receptor-interacting protein 1; RIP-1Homo sapiens (human)
Ubiquitin-conjugating enzyme E2 D3EC 2.3.2.23; (E3-independent) E2 ubiquitin-conjugating enzyme D3; 2.3.2.24; E2 ubiquitin-conjugating enzyme D3; Ubiquitin carrier protein D3; Ubiquitin-conjugating enzyme E2(17)KB 3; Ubiquitin-conjugating enzyme E2-17 kDa 3; Ubiquitin-protein ligase D3Homo sapiens (human)
Ubiquitin-conjugating enzyme E2 D2EC 2.3.2.23; (E3-independent) E2 ubiquitin-conjugating enzyme D2; 2.3.2.24; E2 ubiquitin-conjugating enzyme D2; Ubiquitin carrier protein D2; Ubiquitin-conjugating enzyme E2(17)KB 2; Ubiquitin-conjugating enzyme E2-17 kDa 2; Ubiquitin-protein ligase D2; pHomo sapiens (human)
RanBP-type and C3HC4-type zinc finger-containing protein 1EC 2.3.2.31; HBV-associated factor 4; Heme-oxidized IRP2 ubiquitin ligase 1; HOIL-1; Hepatitis B virus X-associated protein 4; RING finger protein 54; RING-type E3 ubiquitin transferase HOIL-1; Ubiquitin-conjugating enzyme 7-interacting protein 3Homo sapiens (human)
SharpinShank-associated RH domain-interacting protein; Shank-interacting protein-like 1; hSIPL1Homo sapiens (human)
Tumor necrosis factor receptor superfamily member 1ATumor necrosis factor receptor 1; TNF-R1; Tumor necrosis factor receptor type I; TNF-RI; TNFR-I; p55; p60Homo sapiens (human)
NF-kappa-B essential modulatorNEMO; FIP-3; IkB kinase-associated protein 1; IKKAP1; Inhibitor of nuclear factor kappa-B kinase subunit gamma; I-kappa-B kinase subunit gamma; IKK-gamma; IKKG; IkB kinase subunit gamma; NF-kappa-B essential modifierHomo sapiens (human)
Tumor necrosis factorCachectin; TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-aHomo sapiens (human)
E3 ubiquitin-protein ligase RNF31EC 2.3.2.31; HOIL-1-interacting protein; HOIP; RING finger protein 31; RING-type E3 ubiquitin transferase RNF31; Zinc in-between-RING-finger ubiquitin-associated domain proteinHomo sapiens (human)
TNF receptor-associated factor 2EC 2.3.2.27; E3 ubiquitin-protein ligase TRAF2; RING-type E3 ubiquitin transferase TRAF2; Tumor necrosis factor type 2 receptor-associated protein 3Homo sapiens (human)
FAS-associated death domain proteinFAS-associating death domain-containing protein; Growth-inhibiting gene 3 protein; Mediator of receptor induced toxicity; Protein FADDHomo sapiens (human)
TNF receptor-associated factor 1Epstein-Barr virus-induced protein 6Homo sapiens (human)
Ubiquitin-conjugating enzyme E2 L3EC 2.3.2.23; E2 ubiquitin-conjugating enzyme L3; L-UBC; UbcH7; Ubiquitin carrier protein L3; Ubiquitin-conjugating enzyme E2-F1; Ubiquitin-protein ligase L3Homo sapiens (human)
Ubiquitin-conjugating enzyme E2 D1EC 2.3.2.23; (E3-independent) E2 ubiquitin-conjugating enzyme D1; 2.3.2.24; E2 ubiquitin-conjugating enzyme D1; Stimulator of Fe transport; SFT; UBC4/5 homolog; UbcH5; Ubiquitin carrier protein D1; Ubiquitin-conjugating enzyme E2(17)KB 1; Ubiquitin-conjugHomo sapiens (human)
Ubiquitin thioesterase otulinEC 3.4.19.12; Deubiquitinating enzyme otulin; OTU domain-containing deubiquitinase with linear linkage specificity; Ubiquitin thioesterase GumbyHomo sapiens (human)
E3 ubiquitin-protein ligase CHIPEC 2.3.2.27; Antigen NY-CO-7; CLL-associated antigen KW-8; Carboxy terminus of Hsp70-interacting protein; RING-type E3 ubiquitin transferase CHIP; STIP1 homology and U box-containing protein 1Homo sapiens (human)
Uncharacterized protein UL36Human herpesvirus 5 strain AD169
BAG family molecular chaperone regulator 4BAG-4; Bcl-2-associated athanogene 4; Silencer of death domainsHomo sapiens (human)
Receptor of activated protein C kinase 1Cell proliferation-inducing gene 21 protein; Guanine nucleotide-binding protein subunit beta-2-like 1; Guanine nucleotide-binding protein subunit beta-like protein 12.3; Human lung cancer oncogene 7 protein; HLC-7; Receptor for activated C kinase; Small rHomo sapiens (human)
Tumor necrosis factor receptor type 1-associated DEATH domain proteinTNFR1-associated DEATH domain protein; TNFRSF1A-associated via death domainHomo sapiens (human)
Tax1-binding protein 1TRAF6-binding proteinHomo sapiens (human)
Protein FAN Factor associated with neutral sphingomyelinase activation; Factor associated with N-SMase activationHomo sapiens (human)
E3 ubiquitin-protein ligase MIB2EC 2.3.2.27; Mind bomb homolog 2; Novel zinc finger protein; Novelzin; Putative NF-kappa-B-activating protein 002N; RING-type E3 ubiquitin transferase MIB2; Skeletrophin; Zinc finger ZZ type with ankyrin repeat domain protein 1Homo sapiens (human)
OptineurinE3-14.7K-interacting protein; FIP-2; Huntingtin yeast partner L; Huntingtin-interacting protein 7; HIP-7; Huntingtin-interacting protein L; NEMO-related protein; Optic neuropathy-inducing protein; Transcription factor IIIA-interacting protein; TFIIIA-IntPHomo sapiens (human)
CAP-Gly domain-containing linker protein 3Cytoplasmic linker protein 170-related 59 kDa protein; CLIP-170-related 59 kDa protein; CLIPR-59Homo sapiens (human)
Spermatogenesis-associated protein 2Homo sapiens (human)

Compounds (3)

CompoundDescription
ZincA metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.