Synthesis of diphthamide-EEF2

Proteins (8)

Protein	Synonyms	Taxonomy
Elongation factor 2	EF-2	Homo sapiens (human)
Diphthine methyltransferase	EC 3.1.1.97; Diphthamide biosynthesis protein 7; WD repeat-containing protein 85	Homo sapiens (human)
DnaJ homolog subfamily C member 24	CSL-type zinc finger-containing protein 3; Diphthamide biosynthesis protein 4	Homo sapiens (human)
Diphthine--ammonia ligase	EC 6.3.1.14; ATP-binding domain-containing protein 4; Diphthamide synthase; Diphthamide synthetase; Protein DPH6 homolog	Homo sapiens (human)
DPH3 homolog	CSL-type zinc finger-containing protein 2; DelGEF-interacting protein 1; DelGIP1	Homo sapiens (human)
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2	EC 2.5.1.108; Diphthamide biosynthesis protein 2; Diphtheria toxin resistance protein 2; S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2	Homo sapiens (human)
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1	EC 2.5.1.108; Diphthamide biosynthesis protein 1; Diphtheria toxin resistance protein 1; Ovarian cancer-associated gene 1 protein; S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1	Homo sapiens (human)
Diphthine methyl ester synthase	EC 2.1.1.314; Diphthamide biosynthesis methyltransferase	Homo sapiens (human)

Compound	Description
Ammonium
adenosine monophosphate	Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
5'-methylthioadenosine	structure
adenosine triphosphate	An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
s-adenosylmethionine	Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)