Page last updated: 2024-10-06

Regulation of PLK1 Activity at G2/M Transition

Proteins (73)

ProteinSynonymsTaxonomy
Aurora kinase AEC 2.7.11.1; Aurora 2; Aurora/IPL1-related kinase 1; ARK-1; Aurora-related kinase 1; hARK1; Breast tumor-amplified kinase; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase aurora-AHomo sapiens (human)
Cyclin-dependent kinase 1CDK1; EC 2.7.11.22; EC 2.7.11.23; Cell division control protein 2 homolog; Cell division protein kinase 1; p34 protein kinaseHomo sapiens (human)
Tubulin beta chainTubulin beta-5 chainHomo sapiens (human)
Heat shock protein HSP 90-alphaEC 3.6.4.10; Heat shock 86 kDa; HSP 86; HSP86; Lipopolysaccharide-associated protein 2; LAP-2; LPS-associated protein 2; Renal carcinoma antigen NY-REN-38Homo sapiens (human)
G2/mitotic-specific cyclin-B1Homo sapiens (human)
Casein kinase I isoform deltaCKI-delta; CKId; EC 2.7.11.1; Tau-protein kinase CSNK1D; 2.7.11.26Homo sapiens (human)
Casein kinase I isoform epsilonCKI-epsilon; CKIe; EC 2.7.11.1Homo sapiens (human)
Serine/threonine-protein kinase Nek2EC 2.7.11.1; HSPK 21; Never in mitosis A-related kinase 2; NimA-related protein kinase 2; NimA-like protein kinase 1Homo sapiens (human)
Serine/threonine-protein kinase PLK1EC 2.7.11.21; Polo-like kinase 1; PLK-1; Serine/threonine-protein kinase 13; STPK13Homo sapiens (human)
Tubulin alpha-4A chainAlpha-tubulin 1; Testis-specific alpha-tubulin; Tubulin H2-alpha; Tubulin alpha-1 chainHomo sapiens (human)
Centrosomal protein 43FGFR1 oncogene partnerHomo sapiens (human)
G2/mitotic-specific cyclin-B2Homo sapiens (human)
Tubulin beta-4A chainTubulin 5 beta; Tubulin beta-4 chainHomo sapiens (human)
cAMP-dependent protein kinase catalytic subunit alphaPKA C-alpha; EC 2.7.11.11Homo sapiens (human)
Tubulin beta-4B chainTubulin beta-2 chain; Tubulin beta-2C chainHomo sapiens (human)
Tubulin alpha-1A chainAlpha-tubulin 3; Tubulin B-alpha-1; Tubulin alpha-3 chainHomo sapiens (human)
Serine/threonine-protein phosphatase PP1-beta catalytic subunitPP-1B; PPP1CD; EC 3.1.3.16; EC 3.1.3.53Homo sapiens (human)
Cullin-1CUL-1Homo sapiens (human)
Centrosomal protein of 41 kDaCep41; Testis-specific gene A14 proteinHomo sapiens (human)
Centrosomal protein of 57 kDaCep57; FGF2-interacting protein; Testis-specific protein 57; TranslokinHomo sapiens (human)
Centrosomal protein of 78 kDaCep78Homo sapiens (human)
Centrosomal protein of 76 kDaCep76Homo sapiens (human)
Serine/threonine-protein kinase PLK4EC 2.7.11.21; Polo-like kinase 4; PLK-4; Serine/threonine-protein kinase 18; Serine/threonine-protein kinase SakHomo sapiens (human)
14-3-3 protein gammaProtein kinase C inhibitor protein 1; KCIP-1Homo sapiens (human)
Centrosomal protein of 290 kDaCep290; Bardet-Biedl syndrome 14 protein; Cancer/testis antigen 87; CT87; Nephrocystin-6; Tumor antigen se2-2Homo sapiens (human)
Centrosomal protein of 152 kDaCep152Homo sapiens (human)
14-3-3 protein epsilon14-3-3EHomo sapiens (human)
cAMP-dependent protein kinase type II-beta regulatory subunitHomo sapiens (human)
S-phase kinase-associated protein 1Cyclin-A/CDK2-associated protein p19; p19A; Organ of Corti protein 2; OCP-2; Organ of Corti protein II; OCP-II; RNA polymerase II elongation factor-like protein; SIII; Transcription elongation factor B polypeptide 1-like; p19skp1Homo sapiens (human)
Cytoplasmic dynein 1 intermediate chain 2Cytoplasmic dynein intermediate chain 2; Dynein intermediate chain 2, cytosolic; DH IC-2Homo sapiens (human)
PericentrinKendrin; Pericentrin-BHomo sapiens (human)
Nuclear distribution protein nudE homolog 1NudEHomo sapiens (human)
Centrosomal protein of 72 kDaCep72Homo sapiens (human)
Centrosomal protein of 135 kDaCep135; Centrosomal protein 4Homo sapiens (human)
Centrosomal protein of 164 kDaCep164Homo sapiens (human)
Centrosomal protein of 70 kDaCep70; p10-binding proteinHomo sapiens (human)
Alpha-centractinCentractin; ARP1; Actin-RPV; Centrosome-associated actin homologHomo sapiens (human)
Microtubule-associated protein RP/EB family member 1APC-binding protein EB1; End-binding protein 1; EB1Homo sapiens (human)
Centrosomal protein of 192 kDaCep192; Cep192/SPD-2Homo sapiens (human)
Protein phosphatase 1 regulatory subunit 12AMyosin phosphatase-targeting subunit 1; Myosin phosphatase target subunit 1; Protein phosphatase myosin-binding subunitHomo sapiens (human)
Centrosome-associated protein CEP250250 kDa centrosomal protein; Cep250; Centrosomal Nek2-associated protein 1; C-Nap1; Centrosomal protein 2Homo sapiens (human)
Dynein light chain 1, cytoplasmic8 kDa dynein light chain; DLC8; Dynein light chain LC8-type 1; Protein inhibitor of neuronal nitric oxide synthase; PINHomo sapiens (human)
Centrosomal protein of 63 kDaCep63Homo sapiens (human)
Centromere protein JCENP-J; Centrosomal P4.1-associated protein; LAG-3-associated protein; LYST-interacting protein 1Homo sapiens (human)
Protein NEDD1Neural precursor cell expressed developmentally down-regulated protein 1; NEDD-1Homo sapiens (human)
Cytoplasmic dynein 1 heavy chain 1Cytoplasmic dynein heavy chain 1; Dynein heavy chain, cytosolicHomo sapiens (human)
Ras-related protein Rab-8AOncogene c-melHomo sapiens (human)
Protein SFI1 homologhSFI1Homo sapiens (human)
Centriolar coiled-coil protein of 110 kDaCentrosomal protein of 110 kDa; CP110; Cep110Homo sapiens (human)
Sjoegren syndrome nuclear autoantigen 1Nuclear autoantigen of 14 kDaHomo sapiens (human)
Oral-facial-digital syndrome 1 proteinProtein 71-7AHomo sapiens (human)
Dynactin subunit 3Dynactin complex subunit 22 kDa subunit; p22Homo sapiens (human)
Tubulin gamma-1 chainGamma-1-tubulin; Gamma-tubulin complex component 1; GCP-1Homo sapiens (human)
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoformMedium tumor antigen-associated 61 kDa protein; PP2A subunit A isoform PR65-alpha; PP2A subunit A isoform R1-alphaHomo sapiens (human)
Centrin-2Caltractin isoform 1Homo sapiens (human)
Platelet-activating factor acetylhydrolase IB subunit betaLissencephaly-1 protein; LIS-1; PAF acetylhydrolase 45 kDa subunit; PAF-AH 45 kDa subunit; PAF-AH alpha; PAFAH alphaHomo sapiens (human)
Dynactin subunit 250 kDa dynein-associated polypeptide; Dynactin complex 50 kDa subunit; DCTN-50; p50 dynamitinHomo sapiens (human)
Cytoskeleton-associated protein 5Colonic and hepatic tumor overexpressed gene protein; Ch-TOGHomo sapiens (human)
Pericentriolar material 1 proteinPCM-1; hPCM-1Homo sapiens (human)
Outer dense fiber protein 2Cenexin; Outer dense fiber of sperm tails protein 2Homo sapiens (human)
Protein aurora borealisHsBoraHomo sapiens (human)
CLIP-associating protein 1Cytoplasmic linker-associated protein 1; Multiple asters homolog 1; Protein Orbit homolog 1; hOrbit1Homo sapiens (human)
CentriolinCentrosomal protein 1; Centrosomal protein of 110 kDa; Cep110Homo sapiens (human)
Serologically defined colon cancer antigen 8Antigen NY-CO-8; Centrosomal colon cancer autoantigen protein; hCCCAPHomo sapiens (human)
Alstrom syndrome protein 1Homo sapiens (human)
OptineurinE3-14.7K-interacting protein; FIP-2; Huntingtin yeast partner L; Huntingtin-interacting protein 7; HIP-7; Huntingtin-interacting protein L; NEMO-related protein; Optic neuropathy-inducing protein; Transcription factor IIIA-interacting protein; TFIIIA-IntPHomo sapiens (human)
LIM domain-containing protein ajubaHomo sapiens (human)
CDK5 regulatory subunit-associated protein 2CDK5 activator-binding protein C48; Centrosome-associated protein 215Homo sapiens (human)
A-kinase anchor protein 9AKAP-9; A-kinase anchor protein 350 kDa; AKAP 350; hgAKAP 350; A-kinase anchor protein 450 kDa; AKAP 450; AKAP 120-like protein; Centrosome- and Golgi-localized PKN-associated protein; CG-NAP; Protein hyperion; Protein kinase A-anchoring protein 9; PRKA9;Homo sapiens (human)
F-box/WD repeat-containing protein 11F-box and WD repeats protein beta-TrCP2; F-box/WD repeat-containing protein 1B; Homologous to Slimb protein; HOSHomo sapiens (human)
Centrosomal protein of 131 kDa5-azacytidine-induced protein 1; Pre-acrosome localization protein 1Homo sapiens (human)
F-box/WD repeat-containing protein 1AE3RSIkappaB; Epididymis tissue protein Li 2a; F-box and WD repeats protein beta-TrCP; pIkappaBalpha-E3 receptor subunitHomo sapiens (human)
Ninein-like proteinHomo sapiens (human)

Compounds (5)

CompoundDescription
Orthophosphate
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Guanosine MonophosphateA guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature.
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.