PI Metabolism

Proteins (49)

Protein	Synonyms	Taxonomy
Patatin-like phospholipase domain-containing protein 6	EC 3.1.1.5; Neuropathy target esterase	Homo sapiens (human)
Phosphatidylinositol 3-kinase regulatory subunit beta	PI3-kinase regulatory subunit beta; PI3K regulatory subunit beta; PtdIns-3-kinase regulatory subunit beta; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta; PI3-kinase subunit p85-beta; PtdIns-3-kinase regulatory subunit p85-beta	Homo sapiens (human)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PI3-kinase subunit delta; PI3K-delta; PI3Kdelta; PtdIns-3-kinase subunit delta; EC 2.7.1.137; EC 2.7.1.153; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta; PtdIns-3-kinase subunit p110-delta; p110delta	Homo sapiens (human)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	PI3-kinase subunit alpha; PI3K-alpha; PI3Kalpha; PtdIns-3-kinase subunit alpha; EC 2.7.1.137; EC 2.7.1.153; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; PtdIns-3-kinase subunit p110-alpha; p110alpha; Phosphoinositide 3-k	Homo sapiens (human)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PI3-kinase subunit gamma; PI3K-gamma; PI3Kgamma; PtdIns-3-kinase subunit gamma; EC 2.7.1.137; EC 2.7.1.153; EC 2.7.1.154; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma; PtdIns-3-kinase subunit p110-gamma; p110gamma; Phosph	Homo sapiens (human)
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	EC 2.7.1.149; 1-phosphatidylinositol 5-phosphate 4-kinase 2-beta; Diphosphoinositide kinase 2-beta; Phosphatidylinositol 5-phosphate 4-kinase type II beta; PI(5)P 4-kinase type II beta; PIP4KII-beta; PtdIns(5)P-4-kinase isoform 2-beta	Homo sapiens (human)
Phosphatidylinositol 4-kinase beta	PI4K-beta; PI4Kbeta; PtdIns 4-kinase beta; EC 2.7.1.67; NPIK; PI4K92; PI4KIII	Homo sapiens (human)
1-phosphatidylinositol 3-phosphate 5-kinase	Phosphatidylinositol 3-phosphate 5-kinase; EC 2.7.1.150; FYVE finger-containing phosphoinositide kinase; PIKfyve; Phosphatidylinositol 3-phosphate 5-kinase type III; PIPkin-III; Type III PIP kinase; Serine-protein kinase PIKFYVE; 2.7.11.1	Homo sapiens (human)
ADP-ribosylation factor 1		Homo sapiens (human)
Glycerophosphocholine cholinephosphodiesterase ENPP6	GPC-Cpde; EC 3.1.4.-; EC 3.1.4.38; Choline-specific glycerophosphodiester phosphodiesterase; Ectonucleotide pyrophosphatase/phosphodiesterase family member 6; E-NPP 6; NPP-6	Homo sapiens (human)
Phosphatidylinositol 3-kinase regulatory subunit alpha	PI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3-kinase subunit p85-alpha; PtdIns-3-kinase regulatory subunit p85-alpha	Homo sapiens (human)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	PI3-kinase subunit beta; PI3K-beta; PI3Kbeta; PtdIns-3-kinase subunit beta; EC 2.7.1.153; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; PtdIns-3-kinase subunit p110-beta; p110beta	Homo sapiens (human)
Cytoplasmic tyrosine-protein kinase BMX	EC 2.7.10.2; Bone marrow tyrosine kinase gene in chromosome X protein; Epithelial and endothelial tyrosine kinase; ETK; NTK38	Homo sapiens (human)
Tyrosine-protein phosphatase non-receptor type 13	EC 3.1.3.48; Fas-associated protein-tyrosine phosphatase 1; FAP-1; PTP-BAS; Protein-tyrosine phosphatase 1E; PTP-E1; hPTPE1; Protein-tyrosine phosphatase PTPL1	Homo sapiens (human)
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Mutated in multiple advanced cancers 1; Phosphatase and tensin homolog	Homo sapiens (human)
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	PI3K-C2-alpha; PtdIns-3-kinase C2 subunit alpha; EC 2.7.1.137; EC 2.7.1.153; EC 2.7.1.154; Phosphoinositide 3-kinase-C2-alpha	Homo sapiens (human)
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	EC 2.7.1.149; 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha; Diphosphoinositide kinase 2-alpha; PIP5KIII; Phosphatidylinositol 5-Phosphate 4-Kinase; PI5P4Kalpha; Phosphatidylinositol 5-phosphate 4-kinase type II alpha; PI(5)P 4-kinase type II alpha;	Homo sapiens (human)
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	EC 2.7.1.149; Phosphatidylinositol 5-phosphate 4-kinase type II gamma; PI(5)P 4-kinase type II gamma; PIP4KII-gamma	Homo sapiens (human)
Phosphoinositide 3-kinase regulatory subunit 5	PI3-kinase regulatory subunit 5; PI3-kinase p101 subunit; Phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit; PtdIns-3-kinase regulatory subunit; Protein FOAP-2; PtdIns-3-kinase p101; p101-PI3K	Homo sapiens (human)
Phosphatidylinositol 3-kinase regulatory subunit gamma	PI3-kinase regulatory subunit gamma; PI3K regulatory subunit gamma; PtdIns-3-kinase regulatory subunit gamma; Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma; PI3-kinase subunit p55-gamma; PtdIns-3-kinase regulatory subunit p55-gamma; p55PIK	Homo sapiens (human)
Pleckstrin homology domain-containing family A member 1	PH domain-containing family A member 1; Tandem PH domain-containing protein 1; TAPP-1	Homo sapiens (human)
Myotubularin-related protein 6	Phosphatidylinositol-3,5-bisphosphate 3-phosphatase; 3.1.3.95; Phosphatidylinositol-3-phosphate phosphatase; 3.1.3.64	Homo sapiens (human)
Polyphosphoinositide phosphatase	EC 3.1.3.-; Phosphatidylinositol 3,5-bisphosphate 5-phosphatase; SAC domain-containing protein 3	Homo sapiens (human)
Myotubularin-related protein 5	Inactive phosphatidylinositol 3-phosphatase 5; SET-binding factor 1; Sbf1	Homo sapiens (human)
Myotubularin-related protein 10	Inactive phosphatidylinositol 3-phosphatase 10	Homo sapiens (human)
Myotubularin-related protein 7	Inositol 1,3-bisphosphate phosphatase; 3.1.3.-; Phosphatidylinositol-3-phosphate phosphatase; 3.1.3.64	Homo sapiens (human)
Ras-related protein Rab-5A	EC 3.6.5.2	Homo sapiens (human)
Myotubularin-related protein 13	Inactive phosphatidylinositol 3-phosphatase 13; SET-binding factor 2	Homo sapiens (human)
Myotubularin-related protein 12	Inactive phosphatidylinositol 3-phosphatase 12; Phosphatidylinositol 3 phosphate 3-phosphatase adapter subunit; 3-PAP; 3-phosphatase adapter protein	Homo sapiens (human)
Myotubularin-related protein 8	Phosphatidylinositol-3,5-bisphosphate 3-phosphatase; 3.1.3.95; Phosphatidylinositol-3-phosphate phosphatase; 3.1.3.64	Homo sapiens (human)
Ras-related protein Rab-4A		Homo sapiens (human)
Phosphatidylinositol transfer protein beta isoform	PI-TP-beta; PtdIns transfer protein beta; PtdInsTP beta	Homo sapiens (human)
Ras-related protein Rab-14		Homo sapiens (human)
ADP-ribosylation factor 3		Homo sapiens (human)
Protein VAC14 homolog	Tax1-binding protein 2	Homo sapiens (human)
Myotubularin	Phosphatidylinositol-3,5-bisphosphate 3-phosphatase; 3.1.3.95; Phosphatidylinositol-3-phosphate phosphatase; 3.1.3.64	Homo sapiens (human)
Myotubularin-related protein 2	Phosphatidylinositol-3,5-bisphosphate 3-phosphatase; 3.1.3.95; Phosphatidylinositol-3-phosphate phosphatase; 3.1.3.64	Homo sapiens (human)
Phosphoinositide 3-kinase regulatory subunit 6	Phosphoinositide 3-kinase gamma adapter protein of 87 kDa; p84 PI3K adapter protein; p84 PIKAP; p87 PI3K adapter protein; p87PIKAP	Homo sapiens (human)
Patatin-like phospholipase domain-containing protein 7	EC 3.1.1.-; EC 3.1.1.5	Homo sapiens (human)
Lysophospholipase D GDPD3	EC 3.1.4.-; Glycerophosphodiester phosphodiesterase 7; Glycerophosphodiester phosphodiesterase domain-containing protein 3	Homo sapiens (human)
Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase	Type 1 PtdIns-4,5-P2 4-Ptase; EC 3.1.3.78; PtdIns-4,5-P2 4-Ptase I; Transmembrane protein 55B	Homo sapiens (human)
Lysophospholipase D GDPD1	EC 3.1.4.-; Glycerophosphodiester phosphodiesterase 4; Glycerophosphodiester phosphodiesterase domain-containing protein 1	Homo sapiens (human)
Glycerophosphodiester phosphodiesterase domain-containing protein 5	Glycerophosphocholine phosphodiesterase GDPD5; 3.1.4.2; Glycerophosphodiester phosphodiesterase 2; Phosphoinositide phospholipase C GDPD5; 3.1.4.11	Homo sapiens (human)
Myotubularin-related protein 9	Inactive phosphatidylinositol 3-phosphatase 9	Homo sapiens (human)
RUN and FYVE domain-containing protein 1	FYVE-finger protein EIP1; La-binding protein 1; Rab4-interacting protein; Zinc finger FYVE domain-containing protein 12	Homo sapiens (human)
Pleckstrin homology domain-containing family A member 2	PH domain-containing family A member 2; Tandem PH domain-containing protein 2; TAPP-2	Homo sapiens (human)
Phosphatidylinositol-3-phosphatase SAC1	EC 3.1.3.64; Phosphatidylinositol-4-phosphate phosphatase; Suppressor of actin mutations 1-like protein	Homo sapiens (human)
Glycerophosphodiester phosphodiesterase 1	Glycerophosphoinositol glycerophosphodiesterase GDE1; 3.1.4.44; Lysophospholipase D GDE1; 3.1.4.-; Membrane-interacting protein of RGS16; RGS16-interacting membrane protein	Homo sapiens (human)
Phosphatidylinositide phosphatase SAC2	EC 3.1.3.25; Inositol polyphosphate 5-phosphatase F; Sac domain-containing inositol phosphatase 2; Sac domain-containing phosphoinositide 4-phosphatase 2; hSAC2	Homo sapiens (human)

Compounds (10)

Compound	Description
phosphorylcholine	Calcium and magnesium salts used therapeutically in hepatobiliary dysfunction.
choline	A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.
Orthophosphate
adenosine diphosphate	Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
inositol	An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
Water	A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
guanosine triphosphate	Guanosine 5'-(tetrahydrogen triphosphate). A guanine nucleotide containing three phosphate groups esterified to the sugar moiety.
adenosine triphosphate	An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
alpha-glycerophosphoric acid
glycerylphosphorylcholine	A component of PHOSPHATIDYLCHOLINES or LECITHINS, in which the two hydroxy groups of GLYCEROL are esterified with fatty acids. (From Stedman, 26th ed)