| Protein | Synonyms | Taxonomy |
|---|---|---|
| Inhibitor of nuclear factor kappa-B kinase subunit alpha | I-kappa-B kinase alpha; IKK-A; IKK-alpha; IkBKA; IkappaB kinase; EC 2.7.11.10; Conserved helix-loop-helix ubiquitous kinase; I-kappa-B kinase 1; IKK1; Nuclear factor NF-kappa-B inhibitor kinase alpha; NFKBIKA; Transcription factor 16; TCF-16 | Homo sapiens (human) |
| RAF proto-oncogene serine/threonine-protein kinase | EC 2.7.11.1; Proto-oncogene c-RAF; cRaf; Raf-1 | Homo sapiens (human) |
| Proto-oncogene tyrosine-protein kinase Src | EC 2.7.10.2; Proto-oncogene c-Src; pp60c-src; p60-Src | Homo sapiens (human) |
| Serine/threonine-protein kinase PAK 1 | EC 2.7.11.1; Alpha-PAK; p21-activated kinase 1; PAK-1; p65-PAK | Homo sapiens (human) |
| Cytochrome c oxidase subunit 2 | EC 7.1.1.9; Cytochrome c oxidase polypeptide II | Homo sapiens (human) |
| Tyrosine-protein kinase JAK1 | EC 2.7.10.2; Janus kinase 1; JAK-1 | Homo sapiens (human) |
| Phosphatidylinositol 3-kinase regulatory subunit alpha | PI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3-kinase subunit p85-alpha; PtdIns-3-kinase regulatory subunit p85-alpha | Homo sapiens (human) |
| SHC-transforming protein 1 | SHC-transforming protein 3; SHC-transforming protein A; Src homology 2 domain-containing-transforming protein C1; SH2 domain protein C1 | Homo sapiens (human) |
| Signal transducer and activator of transcription 3 | Acute-phase response factor | Homo sapiens (human) |
| Cell division control protein 42 homolog | EC 3.6.5.2; G25K GTP-binding protein | Homo sapiens (human) |
| Growth factor receptor-bound protein 2 | Adapter protein GRB2; Protein Ash; SH2/SH3 adapter GRB2 | Homo sapiens (human) |
| Ras-related C3 botulinum toxin substrate 1 | EC 3.6.5.2; Cell migration-inducing gene 5 protein; Ras-like protein TC25; p21-Rac1 | Homo sapiens (human) |
| Son of sevenless homolog 1 | SOS-1 | Homo sapiens (human) |
| Signal transducer and activator of transcription 1-alpha/beta | Transcription factor ISGF-3 components p91/p84 | Homo sapiens (human) |
| Transforming protein RhoA | EC 3.6.5.2; Rho cDNA clone 12; h12 | Homo sapiens (human) |
| Proto-oncogene vav | Homo sapiens (human) | |
| T-lymphoma invasion and metastasis-inducing protein 1 | TIAM-1 | Homo sapiens (human) |
| Neural Wiskott-Aldrich syndrome protein | N-WASP | Homo sapiens (human) |
| Guanine nucleotide exchange factor VAV2 | VAV-2 | Homo sapiens (human) |
| Arfaptin-2 | ADP-ribosylation factor-interacting protein 2; Partner of RAC1; Protein POR1 | Homo sapiens (human) |
| Compound | Description |
|---|---|
| hydronium ion | |
| Calcium | A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. |
| Sodium | A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23. |
| inositol 1,4,5-trisphosphate | Intracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make up the cell membrane. Inositol 1,4,5-trisphosphate is released into the cytoplasm where it releases calcium ions from internal stores within the cell's endoplasmic reticulum. These calcium ions stimulate the activity of B kinase or calmodulin. |
| arachidonic acid | An unsaturated, essential fatty acid. It is found in animal and human fat as well as in the liver, brain, and glandular organs, and is a constituent of animal phosphatides. It is formed by the synthesis from dietary linoleic acid and is a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes. |
| Cyclic AMP | An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH. |