| Protein | Synonyms | Taxonomy |
|---|
| Histidine biosynthesis bifunctional protein HisB | | Escherichia coli K-12 |
| Histidinol dehydrogenase | HDH; EC 1.1.1.23 | Escherichia coli K-12 |
| ATP phosphoribosyltransferase | ATP-PRT; ATP-PRTase; EC 2.4.2.17 | Escherichia coli K-12 |
| Histidinol-phosphate aminotransferase | EC 2.6.1.9; Imidazole acetol-phosphate transaminase; HPAT; HspAT | Escherichia coli K-12 |
| Imidazole glycerol phosphate synthase subunit HisH | EC 4.3.2.10; IGP synthase glutaminase subunit; 3.5.1.2; IGP synthase subunit HisH; ImGP synthase subunit HisH; IGPS subunit HisH | Escherichia coli K-12 |
| Imidazole glycerol phosphate synthase subunit HisF | EC 4.3.2.10; IGP synthase cyclase subunit; IGP synthase subunit HisF; ImGP synthase subunit HisF; IGPS subunit HisF | Escherichia coli K-12 |
| Histidine biosynthesis bifunctional protein HisIE | | Escherichia coli K-12 |
| 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase | EC 5.3.1.16; Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase | Escherichia coli K-12 |
| Compound | Description |
|---|
| hydronium ion | |
| Orthophosphate | |
| glutamic acid | A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM. |
| NADH | |
| glutamine | A non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from GLUTAMIC ACID and AMMONIA. It is the principal carrier of NITROGEN in the body and is an important energy source for many cells. |
| phosphoribosyl pyrophosphate | The key substance in the biosynthesis of histidine, tryptophan, and purine and pyrimidine nucleotides. |
| Water | A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) |
| BAY o 6997 | structure given in first source |
| alpha-ketoglutaric acid | |
| NAD | A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed) |
| histidine | An essential amino acid that is required for the production of HISTAMINE. |
| histidinol | The penultimate step in the pathway of histidine biosynthesis. Oxidation of the alcohol group on the side chain gives the acid group forming histidine. Histidinol has also been used as an inhibitor of protein synthesis. |
| pyrophosphate | |
| aica ribonucleotide | purine precursor that has antineoplastic activity |
| aminoimidazole carboxamide | An imidazole derivative which is a metabolite of the antineoplastic agents BIC and DIC. By itself, or as the ribonucleotide, it is used as a condensation agent in the preparation of nucleosides and nucleotides. Compounded with orotic acid, it is used to treat liver diseases. |