Page last updated: 2024-09-03

zk 93426 and diazepam

zk 93426 has been researched along with diazepam in 11 studies

Compound Research Comparison

Studies
(zk 93426)
Trials
(zk 93426)
Recent Studies (post-2010)
(zk 93426)
Studies
(diazepam)
Trials
(diazepam)
Recent Studies (post-2010) (diazepam)
565218,3772,3291,790

Protein Interaction Comparison

ProteinTaxonomyzk 93426 (IC50)diazepam (IC50)
Gamma-aminobutyric acid receptor subunit piHomo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit deltaHomo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit alpha-1Bos taurus (cattle)0.0266
Gamma-aminobutyric acid receptor subunit beta-1Bos taurus (cattle)0.0266
Gamma-aminobutyric acid receptor subunit alpha-2Bos taurus (cattle)0.0266
Gamma-aminobutyric acid receptor subunit alpha-3Bos taurus (cattle)0.0266
Gamma-aminobutyric acid receptor subunit alpha-1Homo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit beta-1Homo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit gamma-2Homo sapiens (human)0.0124
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)0.0108
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)0.0227
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit alpha-4Bos taurus (cattle)0.0266
Gamma-aminobutyric acid receptor subunit gamma-2Bos taurus (cattle)0.0266
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)0.0106
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit beta-3Homo sapiens (human)0.0124
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit alpha-5Homo sapiens (human)0.0124
Gamma-aminobutyric acid receptor subunit alpha-3Homo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit alpha-2Homo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit beta-2Homo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit alpha-4Homo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit epsilonHomo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit alpha-6Homo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit gamma-1Homo sapiens (human)0.0101
GABA theta subunitRattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit gamma-3Homo sapiens (human)0.0101
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)0.0108
Gamma-aminobutyric acid receptor subunit thetaHomo sapiens (human)0.0101

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19907 (63.64)18.7374
1990's4 (36.36)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hönack, D; Löscher, W1
Biggio, G; Corda, MG; Fernandez, A; Giorgi, O2
Fassbender, CP; Hönack, D; Löscher, W1
Randall, JI; Rodgers, RJ1
Lister, RG1
Biggio, G; Carcangiu, P; Corda, MG; Giorgi, O; Mereu, G1
Braestrup, C; Honoré, T; Jensen, LH; Kehr, W; Petersen, EN; Schmiechen, R; Schneider, H; Seidelmann, D; Stephens, DN1
Gu, ZQ; Harris, BD; Moody, EJ; Skolnick, P1
Kapetanovic, IM; Kupferberg, HJ; Torchin, CD1
Andrews, N; File, SE1

Other Studies

11 other study(ies) available for zk 93426 and diazepam

ArticleYear
Withdrawal precipitation by benzodiazepine receptor antagonists in dogs chronically treated with diazepam or the novel anxiolytic and anticonvulsant beta-carboline abecarnil.
    Naunyn-Schmiedeberg's archives of pharmacology, 1992, Volume: 345, Issue:4

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; Carbolines; Diazepam; Dogs; Female; Flumazenil; GABA-A Receptor Antagonists; Oxazepam; Substance Withdrawal Syndrome

1992
The beta-carboline derivatives ZK 93426 and FG 7142 fail to precipitate abstinence signs in diazepam-dependent cats.
    Pharmacology, biochemistry, and behavior, 1989, Volume: 32, Issue:3

    Topics: Animals; Carbolines; Cats; Diazepam; Female; Male; Receptors, GABA-A; Substance Withdrawal Syndrome

1989
Physical dependence on diazepam in the dog: precipitation of different abstinence syndromes by the benzodiazepine receptor antagonists Ro 15-1788 and ZK 93426.
    British journal of pharmacology, 1989, Volume: 97, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Carbolines; Diazepam; Dogs; Female; Flumazenil; Nordazepam; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors

1989
Are the analgesic effects of social defeat mediated by benzodiazepine receptors?
    Physiology & behavior, 1987, Volume: 41, Issue:3

    Topics: Analgesia; Animals; Behavior, Animal; Carbolines; Diazepam; Flumazenil; Male; Mice; Mice, Inbred DBA; Pyrazoles; Receptors, GABA-A; Social Behavior

1987
The abstinence syndrome in diazepam-dependent cats is precipitated by Ro 15-1788 and Ro 15-4513 but not by the benzodiazepine receptor antagonist ZK 93426.
    Neuroscience letters, 1988, May-26, Volume: 88, Issue:2

    Topics: Animals; Azides; Benzodiazepines; Carbolines; Cats; Diazepam; Flumazenil; Receptors, GABA-A; Substance Withdrawal Syndrome

1988
Partial reversal of ethanol-induced reductions in exploration by two benzodiazepine antagonists (flumazenil and ZK 93426).
    Brain research bulletin, 1988, Volume: 21, Issue:5

    Topics: Animals; Carbolines; Diazepam; Dose-Response Relationship, Drug; Ethanol; Exploratory Behavior; Flumazenil; Male; Mice; Receptors, GABA-A

1988
The beta-carboline ZK 93423 inhibits reticulata neurons: an effect reversed by benzodiazepine antagonists.
    Life sciences, 1987, Apr-06, Volume: 40, Issue:14

    Topics: Action Potentials; Animals; Carbolines; Diazepam; Flumazenil; Male; Neurons; Rats; Rats, Inbred Strains; Receptors, GABA-A; Substantia Nigra

1987
Evaluation of the beta-carboline ZK 93 426 as a benzodiazepine receptor antagonist.
    Psychopharmacology, 1984, Volume: 83, Issue:3

    Topics: Animals; Anticonvulsants; Ataxia; Benzodiazepinones; Binding, Competitive; Carbolines; Diazepam; Discrimination, Psychological; Drinking; Exploratory Behavior; Flumazenil; gamma-Aminobutyric Acid; In Vitro Techniques; Indoles; Mice; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Receptors, Neurotransmitter; Sleep

1984
Contribution of "diazepam-insensitive" GABAA receptors to the alcohol antagonist properties of Ro 15-4513 and related imidazobenzodiazepines.
    Pharmacology, biochemistry, and behavior, 1995, Volume: 52, Issue:1

    Topics: Alcohol Deterrents; Animals; Azides; Behavior, Animal; Benzodiazepines; Carbolines; Cerebellum; Diazepam; Dose-Response Relationship, Drug; GABA Antagonists; GABA Modulators; GABA-A Receptor Antagonists; Male; Mice; Mice, Inbred Strains

1995
A system for testing the development and reversal of anticonvulsant tolerance to benzodiazepines in mice.
    Epilepsy research, 1993, Volume: 16, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Carbolines; Diazepam; Drug Tolerance; Flumazenil; Flunitrazepam; Infusion Pumps, Implantable; Infusions, Parenteral; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Seizures; Solvents; Time Factors

1993
F 2692: flumazenil-reversible anxiolytic effects but inactive on [3H]-Ro 15-4513 binding.
    Pharmacology, biochemistry, and behavior, 1994, Volume: 48, Issue:1

    Topics: Affinity Labels; Animals; Anti-Anxiety Agents; Azides; Benzodiazepines; Binding, Competitive; Carbolines; Cerebellum; Diazepam; Flumazenil; GABA-A Receptor Antagonists; In Vitro Techniques; Interpersonal Relations; Male; Membranes; Motor Activity; Pyridazines; Rats; Receptors, GABA-A

1994
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