Compounds > vx-745
Page last updated: 2024-09-05

vx-745 and gsk690693

vx-745 has been researched along with gsk690693 in 2 studies

Compound Research Comparison

Studies
(vx-745)		Trials
(vx-745)		Recent Studies (post-2010)
(vx-745)		Studies
(gsk690693)		Trials
(gsk690693)		Recent Studies (post-2010) (gsk690693)
5813552041

Protein Interaction Comparison

ProteinTaxonomyvx-745 (IC50)gsk690693 (IC50)
Death-associated protein kinase 3Homo sapiens (human)0.081
Ribosomal protein S6 kinase alpha-5Homo sapiens (human)1.991
Serine/threonine-protein kinase PAK 4Homo sapiens (human)0.01
Protein kinase C beta typeHomo sapiens (human)0.019
Muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)0.009
Protein kinase C eta typeHomo sapiens (human)0.002
RAC-alpha serine/threonine-protein kinaseHomo sapiens (human)0.0192
RAC-beta serine/threonine-protein kinaseHomo sapiens (human)0.01
RAC-alpha serine/threonine-protein kinaseRattus norvegicus (Norway rat)6.97
Glycogen synthase kinase-3 betaHomo sapiens (human)0.138
cAMP-dependent protein kinase catalytic subunit PRKXHomo sapiens (human)0.005
Protein kinase C epsilon typeHomo sapiens (human)0.021
Protein kinase C theta typeHomo sapiens (human)0.002
Protein kinase C delta typeHomo sapiens (human)0.014
5'-AMP-activated protein kinase catalytic subunit alpha-2Rattus norvegicus (Norway rat)0.05
Rho-associated protein kinase 1Homo sapiens (human)0.2285
cGMP-dependent protein kinase 1 Homo sapiens (human)0.033
Ribosomal protein S6 kinase alpha-1Homo sapiens (human)0.321
Rho-associated protein kinase 1 Rattus norvegicus (Norway rat)0.008
Serine/threonine-protein kinase PAK 6Homo sapiens (human)0.006
Serine/threonine-protein kinase PAK 5Homo sapiens (human)0.052
RAC-gamma serine/threonine-protein kinaseHomo sapiens (human)0.0084

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ciceri, P; Davis, MI; Herrgard, S; Hocker, M; Hunt, JP; Pallares, G; Treiber, DK; Wodicka, LM; Zarrinkar, PP1
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ1

Other Studies

2 other study(ies) available for vx-745 and gsk690693

ArticleYear
Comprehensive analysis of kinase inhibitor selectivity.
    Nature biotechnology, 2011, Oct-30, Volume: 29, Issue:11

    Topics: Catalysis; Drug Design; Enzyme Stability; High-Throughput Screening Assays; Humans; Protein Binding; Protein Kinase Inhibitors; Protein Kinases; Proteomics; Signal Transduction; Substrate Specificity

2011
Identification of potent Yes1 kinase inhibitors using a library screening approach.
    Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15

    Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship

2013