Page last updated: 2024-09-05

vx-745 and cyc 116

vx-745 has been researched along with cyc 116 in 3 studies

Compound Research Comparison

Studies
(vx-745)
Trials
(vx-745)
Recent Studies (post-2010)
(vx-745)
Studies
(cyc 116)
Trials
(cyc 116)
Recent Studies (post-2010) (cyc 116)
5813524018

Protein Interaction Comparison

ProteinTaxonomyvx-745 (IC50)cyc 116 (IC50)
Aurora kinase AHomo sapiens (human)0.026
Cyclin-dependent kinase 4Homo sapiens (human)1.7
Cyclin-A2Homo sapiens (human)0.74
G1/S-specific cyclin-D1Homo sapiens (human)1.7
G1/S-specific cyclin-E1Homo sapiens (human)1.7
Cyclin-dependent kinase 2Homo sapiens (human)1.22
Vascular endothelial growth factor receptor 2Homo sapiens (human)0.069
Receptor-type tyrosine-protein kinase FLT3Homo sapiens (human)0.0566
Aurora kinase BHomo sapiens (human)0.0141
Aurora kinase CHomo sapiens (human)0.065

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hajduk, PJ; Johnson, EF; Kifle, L; Merta, PJ; Metz, JT; Soni, NB1
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ1
Cahya, S; Cummins, DJ; Gao, C; Iversen, PW; Nicolaou, CA; Vieth, M; Wang, J; Watson, IA1

Other Studies

3 other study(ies) available for vx-745 and cyc 116

ArticleYear
Navigating the kinome.
    Nature chemical biology, 2011, Volume: 7, Issue:4

    Topics: Drug Design; Pharmacogenetics; Protein Kinases; Proteome; Systems Biology

2011
Identification of potent Yes1 kinase inhibitors using a library screening approach.
    Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15

    Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship

2013
Selectivity data: assessment, predictions, concordance, and implications.
    Journal of medicinal chemistry, 2013, Sep-12, Volume: 56, Issue:17

    Topics: Computer Simulation; Drug Discovery

2013