u 89678 has been researched along with u 74006f in 10 studies
| Studies (u 89678) | Trials (u 89678) | Recent Studies (post-2010) (u 89678) | Studies (u 74006f) | Trials (u 74006f) | Recent Studies (post-2010) (u 74006f) |
|---|---|---|---|---|---|
| 10 | 4 | 0 | 362 | 49 | 11 |
| Protein | Taxonomy | u 89678 (IC50) | u 74006f (IC50) |
|---|---|---|---|
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | 0.718 | |
| Tyrosine-protein kinase Fyn | Homo sapiens (human) | 1.116 | |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | 7.898 | |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | 2.002 | |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | 0.718 | |
| Mitogen-activated protein kinase 14 | Homo sapiens (human) | 7.406 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fleishaker, JC; Hulst, LK; Peters, GR | 1 |
| Bombardt, PA; Brewer, JE; Johnson, MG | 1 |
| Hall, ED; Scherch, HM; Smith, SL | 1 |
| Fleishaker, JC; Pearson, LK; Peters, GR | 3 |
| Fleishaker, JC; Peters, GR | 2 |
| Cross, CJ; Fleishaker, JC; Straw, RN | 1 |
| Fleishaker, JC; Hauer, MJ; Pearson, PG; Steenwyk, RC; Wienkers, LC | 1 |
4 trial(s) available for u 89678 and u 74006f
| Article | Year |
|---|---|
Gender does not affect the degree of induction of tirilazad clearance by phenobarbital.
Topics: Adult; Blood Pressure; Cross-Over Studies; Drug Interactions; Enzyme Induction; Female; Free Radical Scavengers; Humans; Infusions, Intravenous; Male; Middle Aged; Phenobarbital; Pregnatrienes | 1996 |
Pharmacokinetics of tirilazad and U-89678 in ischemic stroke patients receiving a loading regimen and maintenance regimen of 10 mg/kg/day of tirilazad.
Topics: Aged; Area Under Curve; Brain Ischemia; Female; Humans; Male; Metabolic Clearance Rate; Middle Aged; Neuroprotective Agents; Pregnatrienes | 1996 |
Pharmacokinetics of tirilazad in healthy male subjects at doses above 6 mg/kg/day.
Topics: Adult; Antioxidants; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Male; Middle Aged; Oxidation-Reduction; Pregnatrienes | 1997 |
Induction of tirilazad clearance by phenytoin.
Topics: Adult; Anticonvulsants; Antioxidants; Ataxia; Cross-Over Studies; Dizziness; Dose-Response Relationship, Drug; Drug Interactions; Female; gamma-Glutamyltransferase; Humans; Hydrocortisone; Injections, Intravenous; Male; Middle Aged; Motor Activity; Nystagmus, Pathologic; Phenytoin; Phosphoric Monoester Hydrolases; Pregnatrienes; Sleep Stages; Time Factors | 1998 |
6 other study(ies) available for u 89678 and u 74006f
| Article | Year |
|---|---|
Multiple-dose tolerability and pharmacokinetics of tirilazad mesylate at doses of up to 10 mg/kg/day administered over 5-10 days in healthy volunteers.
Topics: Adult; Chromatography, High Pressure Liquid; Craniocerebral Trauma; Drug Tolerance; Half-Life; Humans; Infusions, Intravenous; Lipid Peroxides; Male; Middle Aged; Pregnatrienes; Subarachnoid Hemorrhage | 1994 |
Protein binding of tirilazad (U-74006) in human, Sprague-Dawley rat, beagle dog and cynomolgus monkey serum.
Topics: Acetonitriles; Adolescent; Adult; Aged; Animals; Binding, Competitive; Blood Proteins; Dialysis; Dogs; Female; Humans; Hydrogen-Ion Concentration; Macaca fascicularis; Male; Middle Aged; Pregnatrienes; Protein Binding; Rats; Rats, Sprague-Dawley; Species Specificity; Ultracentrifugation; Ultrafiltration | 1994 |
Protective effects of tirilazad mesylate and metabolite U-89678 against blood-brain barrier damage after subarachnoid hemorrhage and lipid peroxidative neuronal injury.
Topics: Animals; Antioxidants; Blood-Brain Barrier; Cells, Cultured; Lipid Peroxides; Male; Mice; Mice, Inbred Strains; Neurons; Neuroprotective Agents; Pregnatrienes; Rats; Rats, Sprague-Dawley; Spinal Cord; Subarachnoid Hemorrhage | 1996 |
Comparison of the pharmacokinetics of tirilazad mesylate in healthy volunteers and stable subjects with mild liver cirrhosis.
Topics: Antioxidants; Female; Humans; Infusions, Intravenous; Liver Cirrhosis; Male; Middle Aged; Pregnatrienes | 1996 |
Pharmacokinetics of tirilazad and U-89678, an active, reduced metabolite, following acute head trauma in adults.
Topics: Adult; Area Under Curve; Craniocerebral Trauma; Female; Humans; Male; Neuroprotective Agents; Pregnatrienes | 1997 |
Biotransformation of tirilazad in human: 3. tirilazad A-ring reduction by human liver microsomal 5alpha-reductase type 1 and type 2.
Topics: Biotransformation; Cholestenone 5 alpha-Reductase; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Free Radical Scavengers; Humans; Hydrogen-Ion Concentration; Isoenzymes; Mass Spectrometry; Microsomes, Liver; Neuroprotective Agents; Oxidoreductases; Pregnatrienes | 1998 |