Page last updated: 2024-09-02

exp3174 and fluconazole

exp3174 has been researched along with fluconazole in 2 studies

Compound Research Comparison

Studies
(exp3174)
Trials
(exp3174)
Recent Studies (post-2010)
(exp3174)
Studies
(fluconazole)
Trials
(fluconazole)
Recent Studies (post-2010) (fluconazole)
23629439,3437213,664

Protein Interaction Comparison

ProteinTaxonomyexp3174 (IC50)fluconazole (IC50)
Lanosterol 14-alpha demethylaseCandida albicans SC53140.1296
Cytochrome P450 2C9 Homo sapiens (human)9.21
Sterol 14-alpha demethylaseTrypanosoma cruzi strain CL Brener0.88

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Blum, RA; Boike, SC; Etheredge, R; Ilson, B; Jorkasky, DK; Kazierad, DJ; Martin, DE; Tenero, DM1
Kaukonen, KM; Neuvonen, PJ; Olkkola, KT1

Trials

2 trial(s) available for exp3174 and fluconazole

ArticleYear
Effect of fluconazole on the pharmacokinetics of eprosartan and losartan in healthy male volunteers.
    Clinical pharmacology and therapeutics, 1997, Volume: 62, Issue:4

    Topics: Acrylates; Adult; Antifungal Agents; Antihypertensive Agents; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Drug Administration Schedule; Fluconazole; Humans; Imidazoles; Losartan; Male; Middle Aged; Reference Values; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Tetrazoles; Thiophenes; Time Factors

1997
Fluconazole but not itraconazole decreases the metabolism of losartan to E-3174.
    European journal of clinical pharmacology, 1998, Volume: 53, Issue:6

    Topics: Adult; Antifungal Agents; Antihypertensive Agents; Aryl Hydrocarbon Hydroxylases; Cross-Over Studies; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Double-Blind Method; Drug Interactions; Female; Fluconazole; Humans; Imidazoles; Itraconazole; Losartan; Male; Mixed Function Oxygenases; Reference Values; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Tetrazoles

1998