Page last updated: 2024-09-02

exp3174 and eprosartan

exp3174 has been researched along with eprosartan in 12 studies

Compound Research Comparison

Studies (exp3174)	Trials (exp3174)	Recent Studies (post-2010) (exp3174)	Studies (eprosartan)	Trials (eprosartan)	Recent Studies (post-2010) (eprosartan)
236	29	43	297	83	49

Protein Interaction Comparison

Protein	Taxonomy	eprosartan (IC50)
ATP-binding cassette sub-family C member 3	Homo sapiens (human)	6.65
Type-1A angiotensin II receptor	Rattus norvegicus (Norway rat)	0.1244
Type-1B angiotensin II receptor	Rattus norvegicus (Norway rat)	0.1244
Type-2 angiotensin II receptor	Rattus norvegicus (Norway rat)	0.1217

Research

Studies (12)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	6 (50.00)	18.2507
2000's	4 (33.33)	29.6817
2010's	2 (16.67)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Goldberg, MR; Greenlee, WJ; Irvin, JD; Prendergast, K; Smith, RD; Timmermans, PB; Wexler, RR	1
Schieffer, B; Schmidt, B	1
Berellini, G; Cruciani, G; Mannhold, R	1
Giridhar, R; Murumkar, P; Naik, P; Yadav, MR	1
Fukami, T; Hosomi, H; Iwamura, A; Nakajima, M; Yokoi, T	1
Brooks, DP; DePalma, PD; Ruffolo, RR	1
Brooks, DP; Edwards, RM; Fredrickson, TA; Gellai, M; Ruffolo, RR; Weinstock, J	1
Bauer, JH; Reams, GP	1
Edwards, RM; Stack, EJ; Trizna, W; Weinstock, J	1
Blum, RA; Boike, SC; Etheredge, R; Ilson, B; Jorkasky, DK; Kazierad, DJ; Martin, DE; Tenero, DM	1
Dominiak, P; Häuser, W	1
Ivanova, NA; Preobrazhenskiĭ, DV; Sidorenko, BA; Soplevenko, AV; Stetsenko, TM	1

Reviews

5 review(s) available for exp3174 and eprosartan

Article	Year
Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy. Journal of medicinal chemistry, 1996, Feb-02, Volume: 39, Issue:3 Topics: Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Humans; Receptors, Angiotensin; Structure-Activity Relationship	1996
Angiotensin II AT1 receptor antagonists. Clinical implications of active metabolites. Journal of medicinal chemistry, 2003, Jun-05, Volume: 46, Issue:12 Topics: Acrylates; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Growth Hormone; Humans; Hypertension; Imidazoles; Irbesartan; Losartan; Models, Molecular; Receptor, Angiotensin, Type 1; Tetrazoles; Thiophenes; Thromboxane A2	2003
Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists--a perspective. Bioorganic & medicinal chemistry, 2010, Dec-15, Volume: 18, Issue:24 Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Antihypertensive Agents; Humans; Losartan	2010
The angiotensin II type 1 receptor antagonists. A new class of antihypertensive drugs. Archives of internal medicine, 1995, Jul-10, Volume: 155, Issue:13 Topics: Acrylates; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Benzoates; Biphenyl Compounds; Humans; Imidazoles; Irbesartan; Losartan; Pyridines; Quinolines; Telmisartan; Tetrazoles; Thiophenes; Valine; Valsartan	1995
[Candesartan - a novel AT(1)-angiotensin receptor blocker: peculiarities of pharmacology and experience of use in arterial hypertension]. Kardiologiia, 2004, Volume: 44, Issue:1 Topics: Acrylates; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Diabetic Nephropathies; Humans; Hypertension; Imidazoles; Irbesartan; Losartan; Tetrazoles; Thiophenes; Valine; Valsartan	2004

Trials

1 trial(s) available for exp3174 and eprosartan

Article	Year
Effect of fluconazole on the pharmacokinetics of eprosartan and losartan in healthy male volunteers. Clinical pharmacology and therapeutics, 1997, Volume: 62, Issue:4 Topics: Acrylates; Adult; Antifungal Agents; Antihypertensive Agents; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Drug Administration Schedule; Fluconazole; Humans; Imidazoles; Losartan; Male; Middle Aged; Reference Values; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Tetrazoles; Thiophenes; Time Factors	1997

Article

Year

Effect of fluconazole on the pharmacokinetics of eprosartan and losartan in healthy male volunteers.

Clinical pharmacology and therapeutics, 1997, Volume: 62, Issue:4

Topics: Acrylates; Adult; Antifungal Agents; Antihypertensive Agents; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Drug Administration Schedule; Fluconazole; Humans; Imidazoles; Losartan; Male; Middle Aged; Reference Values; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Tetrazoles; Thiophenes; Time Factors

1997

Other Studies

6 other study(ies) available for exp3174 and eprosartan

Article	Year
Pharmacophore, drug metabolism, and pharmacokinetics models on non-peptide AT1, AT2, and AT1/AT2 angiotensin II receptor antagonists. Journal of medicinal chemistry, 2005, Jun-30, Volume: 48, Issue:13 Topics: Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Binding Sites; Biphenyl Compounds; Kinetics; Losartan; Models, Molecular; Molecular Conformation; Oxidation-Reduction; Pharmaceutical Preparations; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Structure-Activity Relationship; Tetrazoles	2005
CYP2C9-mediated metabolic activation of losartan detected by a highly sensitive cell-based screening assay. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:5 Topics: Antihypertensive Agents; Aryl Hydrocarbon Hydroxylases; Benzbromarone; Biotransformation; Cyclooxygenase Inhibitors; Cytochrome P-450 CYP2C9; Diclofenac; HEK293 Cells; Hep G2 Cells; Hepatocytes; Humans; Losartan; NF-E2-Related Factor 2; Semicarbazides; Sensitivity and Specificity; Time Factors; Uricosuric Agents	2011
Effect of captopril and the nonpeptide angiotensin II antagonists, SK&F 108566 and EXP3174, on renal function in dogs with a renal artery stenosis. The Journal of pharmacology and experimental therapeutics, 1992, Volume: 263, Issue:2 Topics: Acrylates; Angiotensin II; Animals; Blood Pressure; Captopril; Dogs; Dose-Response Relationship, Drug; Female; Glomerular Filtration Rate; Imidazoles; Inulin; Kidney; Losartan; Regional Blood Flow; Renal Artery Obstruction; Tetrazoles; Thiophenes	1992
Antihypertensive activity of the non-peptide angiotensin II receptor antagonist, SK&F 108566, in rats and dogs. Naunyn-Schmiedeberg's archives of pharmacology, 1992, Volume: 345, Issue:6 Topics: Acrylates; Angiotensin I; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Dogs; Hemodynamics; Hypertension; Imidazoles; Losartan; Male; Rats; Rats, Inbred Strains; Tetrazoles; Thiophenes	1992
Interaction of nonpeptide angiotensin II receptor antagonists with the urate transporter in rat renal brush-border membranes. The Journal of pharmacology and experimental therapeutics, 1996, Volume: 276, Issue:1 Topics: Acrylates; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biological Transport; Biphenyl Compounds; Carbon Radioisotopes; Hydrogen-Ion Concentration; Imidazoles; Kidney; Kinetics; Losartan; Male; Microvilli; Naphthalenes; Rats; Rats, Sprague-Dawley; Tetrazoles; Thiophenes; Uric Acid	1996
[Dosage equivalents of AT1-receptor antagonists available in Germany]. Deutsche medizinische Wochenschrift (1946), 2003, Oct-31, Volume: 128, Issue:44 Topics: Acrylates; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Antihypertensive Agents; Benzimidazoles; Benzoates; Biphenyl Compounds; Clinical Trials as Topic; Germany; Humans; Hypertension; Imidazoles; Irbesartan; Losartan; Olmesartan Medoxomil; Placebos; Telmisartan; Tetrazoles; Therapeutic Equivalency; Thiophenes; Time Factors; Valine; Valsartan	2003

chemdatabank.com