Page last updated: 2024-12-11

rustmicin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

rustmicin: active against wheat stem rust fungus; isolated from Streptomyces galbus Micromonospora narashinoensis 980-MC1; MF C21-H32-O6; structure given in first source; also isolated from Streptomyces galbus [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	166639135
MeSH ID	M0137822

Synonyms (3)

Synonym
galbonolide
rustmicin
100227-57-4

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (17)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	3 (17.65)	18.7374
1990's	3 (17.65)	18.2507
2000's	6 (35.29)	29.6817
2010's	5 (29.41)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (5.88%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	16 (94.12%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
inositol Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.. inositol : Any cyclohexane-1,2,3,4,5,6-hexol.. 1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.. muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.	6.99	1	cyclitol; hexol
australifungin australifungin: contains a combination of alpha-diketone and beta-ketoaldehyde groups; from Sporormiella australis; inhibits sphinganine N-acyltransferase (ceramide synthetase); structure given in first source. australifungin : A carbobicyclic compound that is 4a,5,6,7,8,8a-hexahydronaphthalen-1(4H)-one substituted by hydroxy groups at positions 2, 5 and 8, a (2Z)-3-hydroxyprop-2-enoyl group at position 4, methyl groups at positions 4 and 7 and a 2R-octan-2-yl group at position 3 (the 4S,4aR,5S,7R,8R,8aS stereoisomer). It is isolated from the fermentation extracts of Sporormiella australis and exhibits antifungal activity by interfering with the fungal lipid metabolism.	7	1	carbobicyclic compound; enol; enone; secondary alcohol	antifungal agent; EC 2.3.1.24 (sphingosine N-acyltransferase) inhibitor; HIV-1 integrase inhibitor; metabolite
neorustmicin a neorustmicin A: active against wheat stem rust fungus; isolated from Micromonospora chalcea 1302-AV2; MF C21-H32-O5; structure given in first source; has also been isolated from Streptomyces galbus	2.9	4
khafrefungin khafrefungin: inhibits inositol phosphoceramide synthase in fungi; structure in first source	8.51	2
r-106 [no description available]	3.52	2
glycolipids [no description available]	3.51	2

Condition	Relationship Strength	Studies
Fungal Diseases [description not available]	2.93	1
Mycoses Diseases caused by FUNGI.	2.93	1
C gattii Infection [description not available]	1.99	1
Cryptococcosis Fungal infection caused by genus CRYPTOCOCCUS.	1.99	1

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