nematophin profile

nematophin: isolated from Xenorhabdus nematophilus; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	9881952
CHEMBL ID	26598
CHEBI ID	182456
MeSH ID	M0283758

Synonym
CHEBI:182456
n-[2-(1h-indol-3-yl)ethyl]-3-methyl-2-oxopentanamide
pentanamide, n-[2-(1h-indol-3-yl)ethyl]-3-methyl-2-oxo-
CHEMBL26598
nematophin
183314-24-1
DTXSID00432322

Class	Description
indoles	Any compound containing an indole skeleton.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (39)

Assay ID	Title	Year	Journal	Article
AID207068	In vitro inhibitory activity in iso sensitest agar against Staphylococcus aureus strain ATCC 29213 in addition with 5%serum	1998	Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15	Synthesis and antibacterial in vitro activity of novel analogues of nematophin.
AID207067	In vitro inhibitory activity in iso sensitest agar against Staphylococcus aureus strain ATCC 29213 in addition with 5%blood; Not tested	1998	Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15	Synthesis and antibacterial in vitro activity of novel analogues of nematophin.
AID206657	In vitro inhibitory activity in iso sensitest agar against Staphylococcus intermedius strain ATCC 29663	1998	Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15	Synthesis and antibacterial in vitro activity of novel analogues of nematophin.
AID206527	In vitro inhibitory activity in iso sensitest agar against Staphylococcus hyicus strain ATCC 9621 in addition with 5%serum	1998	Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15	Synthesis and antibacterial in vitro activity of novel analogues of nematophin.
AID206662	In vitro inhibitory activity in iso sensitest agar against Staphylococcus intermedius strain ATCC 9503	1998	Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15	Synthesis and antibacterial in vitro activity of novel analogues of nematophin.
AID206525	In vitro inhibitory activity in iso sensitest agar against Staphylococcus hyicus strain ATCC 9621 in addition with 0.5%serum	1998	Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15	Synthesis and antibacterial in vitro activity of novel analogues of nematophin.
AID206528	In vitro inhibitory activity in iso sensitest agar against Staphylococcus hyicus strain ATCC 9622	1998	Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15	Synthesis and antibacterial in vitro activity of novel analogues of nematophin.
AID207065	In vitro inhibitory activity in iso sensitest agar against Staphylococcus aureus strain ATCC 29213 in addition with 0.5%blood; Not tested	1998	Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15	Synthesis and antibacterial in vitro activity of novel analogues of nematophin.
AID206523	In vitro inhibitory activity in iso sensitest agar against Staphylococcus hyicus strain ATCC 9621	1998	Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15	Synthesis and antibacterial in vitro activity of novel analogues of nematophin.
AID206532	In vitro inhibitory activity in iso sensitest agar against Staphylococcus hyicus strain ATCC 9622 in addition with 5%serum	1998	Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15	Synthesis and antibacterial in vitro activity of novel analogues of nematophin.
AID207074	In vitro inhibitory activity in iso sensitest agar against Staphylococcus aureus strain ATCC 6538 in addition with 5%serum	1998	Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15	Synthesis and antibacterial in vitro activity of novel analogues of nematophin.
AID206673	In vitro inhibitory activity in iso sensitest agar against Staphylococcus intermedius strain ATCC 9503 in addition with 5%serum	1998	Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15	Synthesis and antibacterial in vitro activity of novel analogues of nematophin.
AID206672	In vitro inhibitory activity in iso sensitest agar against Staphylococcus intermedius strain ATCC 9503 in addition with 5%blood	1998	Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15	Synthesis and antibacterial in vitro activity of novel analogues of nematophin.
AID207073	In vitro inhibitory activity in iso sensitest agar against Staphylococcus aureus strain ATCC 6538 in addition with 5%blood	1998	Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15	Synthesis and antibacterial in vitro activity of novel analogues of nematophin.
AID207059	In vitro inhibitory activity in iso sensitest agar against Staphylococcus aureus strain ATCC 25923 in addition with 0.5%blood; Not tested	1998	Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15	Synthesis and antibacterial in vitro activity of novel analogues of nematophin.
AID206670	In vitro inhibitory activity in iso sensitest agar against Staphylococcus intermedius strain ATCC 9503 in addition with 0.5%blood	1998	Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15	Synthesis and antibacterial in vitro activity of novel analogues of nematophin.
AID206671	In vitro inhibitory activity in iso sensitest agar against Staphylococcus intermedius strain ATCC 9503 in addition with 0.5%serum	1998	Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15	Synthesis and antibacterial in vitro activity of novel analogues of nematophin.
AID207791	Minimum inhibitory concentration against methicillin sensitive organism Staphylococcus aureus 853	2000	Bioorganic & medicinal chemistry letters, Aug-07, Volume: 10, Issue:15	Studies on the novel anti-staphyloccal compound nematophin.
AID207064	In vitro inhibitory activity in iso sensitest agar against Staphylococcus aureus strain ATCC 29213	1998	Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15	Synthesis and antibacterial in vitro activity of novel analogues of nematophin.
AID40763	Minimum inhibitory concentration against Bacillus subtilis	2000	Bioorganic & medicinal chemistry letters, Aug-07, Volume: 10, Issue:15	Studies on the novel anti-staphyloccal compound nematophin.
AID206530	In vitro inhibitory activity in iso sensitest agar against Staphylococcus hyicus strain ATCC 9622 in addition with 0.5%serum	1998	Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15	Synthesis and antibacterial in vitro activity of novel analogues of nematophin.
AID207066	In vitro inhibitory activity in iso sensitest agar against Staphylococcus aureus strain ATCC 29213 in addition with 0.5%serum; Not tested	1998	Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15	Synthesis and antibacterial in vitro activity of novel analogues of nematophin.
AID206531	In vitro inhibitory activity in iso sensitest agar against Staphylococcus hyicus strain ATCC 9622 in addition with 5%blood	1998	Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15	Synthesis and antibacterial in vitro activity of novel analogues of nematophin.
AID206524	In vitro inhibitory activity in iso sensitest agar against Staphylococcus hyicus strain ATCC 9621 in addition with 0.5%blood	1998	Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15	Synthesis and antibacterial in vitro activity of novel analogues of nematophin.
AID207071	In vitro inhibitory activity in iso sensitest agar against Staphylococcus aureus strain ATCC 6538 in addition with 0.5%blood	1998	Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15	Synthesis and antibacterial in vitro activity of novel analogues of nematophin.
AID207070	In vitro inhibitory activity in iso sensitest agar against Staphylococcus aureus strain ATCC 6538	1998	Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15	Synthesis and antibacterial in vitro activity of novel analogues of nematophin.
AID206526	In vitro inhibitory activity in iso sensitest agar against Staphylococcus hyicus strain ATCC 9621 in addition with 5%blood	1998	Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15	Synthesis and antibacterial in vitro activity of novel analogues of nematophin.
AID207072	In vitro inhibitory activity in iso sensitest agar against Staphylococcus aureus strain ATCC 6538 in addition with 0.5%serum	1998	Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15	Synthesis and antibacterial in vitro activity of novel analogues of nematophin.
AID207060	In vitro inhibitory activity in iso sensitest agar against Staphylococcus aureus strain ATCC 25923 in addition with 0.5%serum; Not tested	1998	Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15	Synthesis and antibacterial in vitro activity of novel analogues of nematophin.
AID207062	In vitro inhibitory activity in iso sensitest agar against Staphylococcus aureus strain ATCC 25923 in addition with 5%serum	1998	Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15	Synthesis and antibacterial in vitro activity of novel analogues of nematophin.
AID207058	In vitro inhibitory activity in iso sensitest agar against Staphylococcus aureus strain ATCC 25923	1998	Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15	Synthesis and antibacterial in vitro activity of novel analogues of nematophin.
AID207061	In vitro inhibitory activity in iso sensitest agar against Staphylococcus aureus strain ATCC 25923 in addition with 5%blood; Not tested	1998	Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15	Synthesis and antibacterial in vitro activity of novel analogues of nematophin.
AID206669	In vitro inhibitory activity in iso sensitest agar against Staphylococcus intermedius strain ATCC 29663 in addition with 5%serum	1998	Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15	Synthesis and antibacterial in vitro activity of novel analogues of nematophin.
AID206667	In vitro inhibitory activity in iso sensitest agar against Staphylococcus intermedius strain ATCC 29663 in addition with 0.5%serum; Not tested	1998	Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15	Synthesis and antibacterial in vitro activity of novel analogues of nematophin.
AID206666	In vitro inhibitory activity in iso sensitest agar against Staphylococcus intermedius strain ATCC 29663 in addition with 0.5%blood; Not tested	1998	Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15	Synthesis and antibacterial in vitro activity of novel analogues of nematophin.
AID206668	In vitro inhibitory activity in iso sensitest agar against Staphylococcus intermedius strain ATCC 29663 in addition with 5%blood; Not tested	1998	Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15	Synthesis and antibacterial in vitro activity of novel analogues of nematophin.
AID207785	Activity against methicillin sensitive organism Staphylococcus aureus 853 in presence of serum.	2000	Bioorganic & medicinal chemistry letters, Aug-07, Volume: 10, Issue:15	Studies on the novel anti-staphyloccal compound nematophin.
AID207790	Minimum inhibitory concentration against methicillin resistant organism Staphylococcus aureus COL	2000	Bioorganic & medicinal chemistry letters, Aug-07, Volume: 10, Issue:15	Studies on the novel anti-staphyloccal compound nematophin.
AID206529	In vitro inhibitory activity in iso sensitest agar against Staphylococcus hyicus strain ATCC 9622 in addition with 0.5%blood	1998	Bioorganic & medicinal chemistry letters, Aug-04, Volume: 8, Issue:15	Synthesis and antibacterial in vitro activity of novel analogues of nematophin.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	2 (25.00)	18.2507
2000's	3 (37.50)	29.6817
2010's	3 (37.50)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	8 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies
1-fluoro-2-nitrobenzene 1-fluoro-2-nitrobenzene: structure given in first source	2	1
xenocoumacin 2 xenocoumacin 2: from Xenorhabdus; RN from Chem Abstr. Index Guide 1991; structure given in first source	2.15	1
xenocoumacin 1 xenocoumacin 1: from Xenorhabdus; RN from Chem Abstr. Index Guide 1990; structure given in first source	2.58	2

nematophin

Description

Cross-References

Synonyms (7)

Drug Classes (1)

Bioassays (39)

Research

Studies (8)

Market Indicators

Research Demand Index: 12.38

Study Types

nematophin

Description

Cross-References

Synonyms (7)

Drug Classes (1)

Bioassays (39)

Research

Studies (8)

Market Indicators

Research Demand Index: 12.38

Study Types

Related Drugs (3)

Related Conditions (1)