xenocoumacin 1

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

xenocoumacin 1: from Xenorhabdus; RN from Chem Abstr. Index Guide 1990; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	163752
CHEMBL ID	492201
MeSH ID	M0194787

Synonyms (6)

Synonym
xenocoumacin 1
CHEMBL492201
105688-01-5
4-amino-7-(diaminomethylideneamino)-2,3-dihydroxy-n-[1-(8-hydroxy-1-oxo-3,4-dihydroisochromen-3-yl)-3-methylbutyl]heptanamide
4-amino-7-((aminoiminomethyl)amino)-4,5,6,7-tetradeoxy-n-(1-(3,4-dihydro-8-hydroxy-1-oxo-1h-2-benzopyran-3-yl)-3-methylbutyl)heptonamide
heptonamide, 4-amino-7-((aminoiminomethyl)amino)-4,5,6,7-tetradeoxy-n-(1-(3,4-dihydro-8-hydroxy-1-oxo-1h-2-benzopyran-3-yl)-3-methylbutyl)-

Research Excerpts

Dosage Studied

Excerpt	Relevance	Reference
" Both compounds exhibit antibacterial activity and potent antiulcer activity against stress-induced ulcers when dosed orally."	( Biologically active metabolites from Xenorhabdus spp., Part 2. Benzopyran-1-one derivatives with gastroprotective activity. Akhurst, RJ; Gregson, RP; Lacey, MJ; McInerney, BV; Taylor, WC, )	0.13

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (20)

Assay ID	Title	Year	Journal	Article
AID337416	Antimicrobial activity against Staphylococcus aureus V573
AID337187	Antimicrobial activity against Escherichia coli ESS
AID337408	Antimicrobial activity against Salmonella Typhimurium CT10
AID337414	Antimicrobial activity against Sarcina lutea ATCC 8740
AID337413	Antimicrobial activity against Corynebacterium xerosis NCTC 9755
AID337417	Antimicrobial activity against Streptococcus pyogenes CN10
AID337192	Antimicrobial activity against Citrobacter freundii ES
AID337409	Antimicrobial activity against Proteus mirabilis C977
AID337415	Antimicrobial activity against Staphylococcus aureus Oxford NCTC 6571
AID337410	Antimicrobial activity against Pseudomonas aeruginosa 1771P
AID337419	Antimicrobial activity against Cryptococcus neoformans
AID337412	Antimicrobial activity against Bacillus megaterium NCIB 9376
AID337426	Antiulcerogenic activity in stress-induced Wistar rat assessed as protection from ulcer at 25 mg/kg, po
AID337427	Antiulcerogenic activity in stress-induced Wistar rat assessed as protection from ulcer at 10 mg/kg, po
AID337190	Antimicrobial activity against Enterobacter cloacae N1
AID337189	Antimicrobial activity against Escherichia coli DCO
AID337411	Antimicrobial activity against Acinetobacter lwoffii BRL 2400
AID337191	Antimicrobial activity against Klebsiella aerogenes A
AID337188	Antimicrobial activity against Escherichia coli 10418
AID337418	Antimicrobial activity against Streptococcus sanguis ATCC 10556
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (28.57)	29.6817
2010's	4 (57.14)	24.3611
2020's	1 (14.29)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	8 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
xenocoumacin 2 xenocoumacin 2: from Xenorhabdus; RN from Chem Abstr. Index Guide 1991; structure given in first source	2.76	3	0
nematophin nematophin: isolated from Xenorhabdus nematophilus; structure in first source	2.58	2	0	indoles

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