Compounds > methiozolin
Page last updated: 2024-11-12

methiozolin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID11500973
CHEMBL ID2269868
SCHEMBL ID271467
MeSH IDM0590050

Synonyms (16)

Synonym
5-[(2,6-difluorophenyl)methoxymethyl]-5-methyl-3-(3-methylthiophen-2-yl)-4h-1,2-oxazole
CHEMBL2269868
methiozolin [iso]
5-(((2,6-difluorophenyl)methoxy)methyl)-4,5-dihydro-5-methyl-3-(3-methyl-2-thienyl)isoxazole
unii-mk1kz980dk
403640-27-7
methiozolin
(5rs)-5-((2,6-difluorobenzyloxy)methyl)-4,5-dihydro-5-methyl-3-(3-methyl-2-thienyl)-1,2-oxazole
mk1kz980dk ,
isoxazole, 5-(((2,6-difluorophenyl)methoxy)methyl)-4,5-dihydro-5-methyl-3-(3-methyl-2-thienyl)-
SCHEMBL271467
DTXSID30895800
isoxazole, 5-[[(2,6-difluorophenyl)methoxy]methyl]-4,5-dihydro-5-methyl-3-(3-methyl-2-thienyl)-; 5-[[(2,6-difluorophenyl)methoxy]methyl]-4,5-dihydro-5-methyl-3-(3-methyl-2-thienyl)isoxazole
Q27284081
methiozolin 100 microg/ml in acetonitrile
isoxazole, 5-[[(2,6-difluorophenyl)methoxy]methyl]-4,5-dihydro-5-methyl-3-(3-methyl-2-thienyl)-

Research Excerpts

Overview

Methiozolin is a new turf herbicide controlling annual bluegrass in various cool- and warm-season turfgrasses. It is also used to control annual crabgrass (Digitaria sanguinalis (L.) Scop.) in various turfgrass.

ExcerptReferenceRelevance
"Methiozolin is a novel herbicide for controlling annual bluegrass. "( Dissipation of Herbicide Methiozolin and Its Metabolites in Aerobic Sediment-Water Systems.
An, JY; Hwang, KH; Kim, JH; Koo, SJ; Kwon, YS; Seo, JS, 2020)		2.3
"Methiozolin is an excellent candidate for annual bluegrass management in turfgrasses."( Methiozolin [5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3,3(3-methylthiophen-2-yl)-1,2-isoxazoline], a new annual bluegrass (Poa annua L.) herbicide for turfgrasses.
Cho, NG; Hwang, KH; Jeon, MS; Kim, SH; Koo, SJ; Lee, DG; Lim, J, 2014)		3.29
"Methiozolin is a new turf herbicide controlling annual bluegrass in various cool- and warm-season turfgrasses. "( Soil metabolism of [14C]methiozolin under aerobic and anaerobic flooded conditions.
Chang, HR; Hwang, KH; Kim, JH; Kim, K; Kim, SH; Koo, SJ; Lim, JS, 2013)		2.14
"Methiozolin is a herbicide currently used for annual bluegrass control in golf course putting greens. "( Methiozolin sorption and mobility in sand-based root zones.
Flessner, ML; Howe, JA; McElroy, JS; Wehtje, GR, 2015)		3.3
"Methiozolin is a new herbicide to control annual bluegrass (Poa annua L.) and large crabgrass (Digitaria sanguinalis (L.) Scop.) in various turfgrasses. "( Developmental toxicity assessment of the new turf herbicide, methiozolin ([5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3,3(3-methylthiophen-2-yl)-1,2-isoxazoline]), in rabbits.
Chung, MK; Hwang, KH; Jeong, EJ; Koo, SJ; Lee, J; Song, J; Yu, WJ, 2015)		2.1

Toxicity

ExcerptReferenceRelevance
" In the current experimental conditions, the no observed adverse effect levels (NOAELs) of methiozolin are considered to be 250 mg/kg/day for does and prenatal development."( Developmental toxicity assessment of the new turf herbicide, methiozolin ([5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3,3(3-methylthiophen-2-yl)-1,2-isoxazoline]), in rabbits.
Chung, MK; Hwang, KH; Jeong, EJ; Koo, SJ; Lee, J; Song, J; Yu, WJ, 2015)		0.88
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (40)

Assay IDTitleYearJournalArticle
AID1103557Toxicity in transplanted Oryza sativa (rice) assessed as visual damage 500 g/ha measured after 5 days after transplanting2005Journal of agricultural and food chemistry, Nov-02, Volume: 53, Issue:22
5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3-(3-methylthiophen-2-yl)- 1,2-isoxazoline as a useful rice herbicide.
AID1103542Herbicidal activity against Rotala indica assessed as visual damage 1000 g/ha measured after 3 weeks2005Journal of agricultural and food chemistry, Nov-02, Volume: 53, Issue:22
5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3-(3-methylthiophen-2-yl)- 1,2-isoxazoline as a useful rice herbicide.
AID1103550Herbicidal activity against Echinochloa oryzicola assessed as visual damage 125 g/ha measured after 3 weeks2005Journal of agricultural and food chemistry, Nov-02, Volume: 53, Issue:22
5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3-(3-methylthiophen-2-yl)- 1,2-isoxazoline as a useful rice herbicide.
AID1103537Herbicidal activity against Murdannia keisak assessed as visual damage 125 g/ha measured after 3 weeks2005Journal of agricultural and food chemistry, Nov-02, Volume: 53, Issue:22
5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3-(3-methylthiophen-2-yl)- 1,2-isoxazoline as a useful rice herbicide.
AID1103533Herbicidal activity against Cyperus difformis assessed as visual damage 250 g/ha measured after 3 weeks2005Journal of agricultural and food chemistry, Nov-02, Volume: 53, Issue:22
5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3-(3-methylthiophen-2-yl)- 1,2-isoxazoline as a useful rice herbicide.
AID1103538Herbicidal activity against Murdannia keisak assessed as visual damage 250 g/ha measured after 3 weeks2005Journal of agricultural and food chemistry, Nov-02, Volume: 53, Issue:22
5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3-(3-methylthiophen-2-yl)- 1,2-isoxazoline as a useful rice herbicide.
AID1103545Herbicidal activity against Monochoria vaginalis assessed as visual damage 500 g/ha measured after 3 weeks2005Journal of agricultural and food chemistry, Nov-02, Volume: 53, Issue:22
5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3-(3-methylthiophen-2-yl)- 1,2-isoxazoline as a useful rice herbicide.
AID1103530Herbicidal activity against Ludwigia prostrata assessed as visual damage 1000 g/ha measured after 3 weeks2005Journal of agricultural and food chemistry, Nov-02, Volume: 53, Issue:22
5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3-(3-methylthiophen-2-yl)- 1,2-isoxazoline as a useful rice herbicide.
AID1103529Herbicidal activity against Ludwigia prostrata assessed as visual damage 500 g/ha measured after 3 weeks2005Journal of agricultural and food chemistry, Nov-02, Volume: 53, Issue:22
5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3-(3-methylthiophen-2-yl)- 1,2-isoxazoline as a useful rice herbicide.
AID1103519Genotoxicity in Cricetulus griseus lung fibroblast assessed as mutation2005Journal of agricultural and food chemistry, Nov-02, Volume: 53, Issue:22
5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3-(3-methylthiophen-2-yl)- 1,2-isoxazoline as a useful rice herbicide.
AID1103536Herbicidal activity against Murdannia keisak assessed as visual damage 62.5 g/ha measured after 3 weeks2005Journal of agricultural and food chemistry, Nov-02, Volume: 53, Issue:22
5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3-(3-methylthiophen-2-yl)- 1,2-isoxazoline as a useful rice herbicide.
AID1103556Toxicity in transplanted Oryza sativa (rice) assessed as visual damage 250 g/ha measured after 5 days after transplanting2005Journal of agricultural and food chemistry, Nov-02, Volume: 53, Issue:22
5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3-(3-methylthiophen-2-yl)- 1,2-isoxazoline as a useful rice herbicide.
AID1103558Toxicity in transplanted Oryza sativa (rice) assessed as visual damage 1000 g/ha measured after 5 days after transplanting2005Journal of agricultural and food chemistry, Nov-02, Volume: 53, Issue:22
5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3-(3-methylthiophen-2-yl)- 1,2-isoxazoline as a useful rice herbicide.
AID1103531Herbicidal activity against Cyperus difformis assessed as visual damage 62.5 g/ha measured after 3 weeks2005Journal of agricultural and food chemistry, Nov-02, Volume: 53, Issue:22
5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3-(3-methylthiophen-2-yl)- 1,2-isoxazoline as a useful rice herbicide.
AID1103544Herbicidal activity against Monochoria vaginalis assessed as visual damage 250 g/ha measured after 3 weeks2005Journal of agricultural and food chemistry, Nov-02, Volume: 53, Issue:22
5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3-(3-methylthiophen-2-yl)- 1,2-isoxazoline as a useful rice herbicide.
AID1103552Herbicidal activity against Echinochloa oryzicola assessed as visual damage 500 g/ha measured after 3 weeks2005Journal of agricultural and food chemistry, Nov-02, Volume: 53, Issue:22
5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3-(3-methylthiophen-2-yl)- 1,2-isoxazoline as a useful rice herbicide.
AID1103546Herbicidal activity against Monochoria vaginalis assessed as visual damage 1000 g/ha measured after 3 weeks2005Journal of agricultural and food chemistry, Nov-02, Volume: 53, Issue:22
5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3-(3-methylthiophen-2-yl)- 1,2-isoxazoline as a useful rice herbicide.
AID1103522Aquatic toxicity in Daphnia magna2005Journal of agricultural and food chemistry, Nov-02, Volume: 53, Issue:22
5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3-(3-methylthiophen-2-yl)- 1,2-isoxazoline as a useful rice herbicide.
AID1103532Herbicidal activity against Cyperus difformis assessed as visual damage 125 g/ha measured after 3 weeks2005Journal of agricultural and food chemistry, Nov-02, Volume: 53, Issue:22
5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3-(3-methylthiophen-2-yl)- 1,2-isoxazoline as a useful rice herbicide.
AID1103535Herbicidal activity against Cyperus difformis assessed as visual damage 1000 g/ha measured after 3 weeks2005Journal of agricultural and food chemistry, Nov-02, Volume: 53, Issue:22
5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3-(3-methylthiophen-2-yl)- 1,2-isoxazoline as a useful rice herbicide.
AID1103553Herbicidal activity against Echinochloa oryzicola assessed as visual damage 1000 g/ha measured after 3 weeks2005Journal of agricultural and food chemistry, Nov-02, Volume: 53, Issue:22
5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3-(3-methylthiophen-2-yl)- 1,2-isoxazoline as a useful rice herbicide.
AID1103523Acute toxicity in Mus musculus (mouse)2005Journal of agricultural and food chemistry, Nov-02, Volume: 53, Issue:22
5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3-(3-methylthiophen-2-yl)- 1,2-isoxazoline as a useful rice herbicide.
AID1103543Herbicidal activity against Monochoria vaginalis assessed as visual damage 125 g/ha measured after 3 weeks2005Journal of agricultural and food chemistry, Nov-02, Volume: 53, Issue:22
5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3-(3-methylthiophen-2-yl)- 1,2-isoxazoline as a useful rice herbicide.
AID1103548Herbicidal activity against Schoenoplectiella juncoides assessed as visual damage 125 g/ha measured after 3 weeks2005Journal of agricultural and food chemistry, Nov-02, Volume: 53, Issue:22
5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3-(3-methylthiophen-2-yl)- 1,2-isoxazoline as a useful rice herbicide.
AID1103541Herbicidal activity against Rotala indica assessed as visual damage 500 g/ha measured after 3 weeks2005Journal of agricultural and food chemistry, Nov-02, Volume: 53, Issue:22
5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3-(3-methylthiophen-2-yl)- 1,2-isoxazoline as a useful rice herbicide.
AID1103547Herbicidal activity against Schoenoplectiella juncoides assessed as visual damage 62.5 g/ha measured after 3 weeks2005Journal of agricultural and food chemistry, Nov-02, Volume: 53, Issue:22
5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3-(3-methylthiophen-2-yl)- 1,2-isoxazoline as a useful rice herbicide.
AID1103527Herbicidal activity against Ludwigia prostrata assessed as visual damage 125 g/ha measured after 3 weeks2005Journal of agricultural and food chemistry, Nov-02, Volume: 53, Issue:22
5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3-(3-methylthiophen-2-yl)- 1,2-isoxazoline as a useful rice herbicide.
AID1103551Herbicidal activity against Echinochloa oryzicola assessed as visual damage 250 g/ha measured after 3 weeks2005Journal of agricultural and food chemistry, Nov-02, Volume: 53, Issue:22
5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3-(3-methylthiophen-2-yl)- 1,2-isoxazoline as a useful rice herbicide.
AID1103549Herbicidal activity against Schoenoplectiella juncoides assessed as visual damage 250 g/ha measured after 3 weeks2005Journal of agricultural and food chemistry, Nov-02, Volume: 53, Issue:22
5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3-(3-methylthiophen-2-yl)- 1,2-isoxazoline as a useful rice herbicide.
AID1103521Aquatic toxicity in Oryzias latipes (Japanese medaka)2005Journal of agricultural and food chemistry, Nov-02, Volume: 53, Issue:22
5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3-(3-methylthiophen-2-yl)- 1,2-isoxazoline as a useful rice herbicide.
AID1103539Herbicidal activity against Rotala indica assessed as visual damage 125 g/ha measured after 3 weeks2005Journal of agricultural and food chemistry, Nov-02, Volume: 53, Issue:22
5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3-(3-methylthiophen-2-yl)- 1,2-isoxazoline as a useful rice herbicide.
AID1103528Herbicidal activity against Ludwigia prostrata assessed as visual damage 250 g/ha measured after 3 weeks2005Journal of agricultural and food chemistry, Nov-02, Volume: 53, Issue:22
5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3-(3-methylthiophen-2-yl)- 1,2-isoxazoline as a useful rice herbicide.
AID1103525Herbicidal activity against 2 to 3 leaf stage Echinochloa crus-galli (barnyard grass) (barnyardgrass) at 62.5 g/ha2005Journal of agricultural and food chemistry, Nov-02, Volume: 53, Issue:22
5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3-(3-methylthiophen-2-yl)- 1,2-isoxazoline as a useful rice herbicide.
AID1103554Toxicity in transplanted Oryza sativa (rice) assessed as visual damage 62.5 g/ha measured after 5 days after transplanting2005Journal of agricultural and food chemistry, Nov-02, Volume: 53, Issue:22
5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3-(3-methylthiophen-2-yl)- 1,2-isoxazoline as a useful rice herbicide.
AID1103526Herbicidal activity against Ludwigia prostrata assessed as visual damage 62.5 g/ha measured after 3 weeks2005Journal of agricultural and food chemistry, Nov-02, Volume: 53, Issue:22
5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3-(3-methylthiophen-2-yl)- 1,2-isoxazoline as a useful rice herbicide.
AID1103524Herbicidal activity against 4 leaf stage Echinochloa crus-galli (barnyard grass) (barnyardgrass) at 250 g/ha2005Journal of agricultural and food chemistry, Nov-02, Volume: 53, Issue:22
5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3-(3-methylthiophen-2-yl)- 1,2-isoxazoline as a useful rice herbicide.
AID1103534Herbicidal activity against Cyperus difformis assessed as visual damage 500 g/ha measured after 3 weeks2005Journal of agricultural and food chemistry, Nov-02, Volume: 53, Issue:22
5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3-(3-methylthiophen-2-yl)- 1,2-isoxazoline as a useful rice herbicide.
AID1103520Genotoxicity inCricetulus griseus lung fibroblast assessed as chromosome aberration2005Journal of agricultural and food chemistry, Nov-02, Volume: 53, Issue:22
5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3-(3-methylthiophen-2-yl)- 1,2-isoxazoline as a useful rice herbicide.
AID1103540Herbicidal activity against Rotala indica assessed as visual damage 250 g/ha measured after 3 weeks2005Journal of agricultural and food chemistry, Nov-02, Volume: 53, Issue:22
5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3-(3-methylthiophen-2-yl)- 1,2-isoxazoline as a useful rice herbicide.
AID1103555Toxicity in transplanted Oryza sativa (rice) assessed as visual damage 125 g/ha measured after 5 days after transplanting2005Journal of agricultural and food chemistry, Nov-02, Volume: 53, Issue:22
5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3-(3-methylthiophen-2-yl)- 1,2-isoxazoline as a useful rice herbicide.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (12.50)29.6817
2010's6 (75.00)24.3611
2020's1 (12.50)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 25.26

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index25.26 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index5.43 (4.65)
Search Engine Demand Index42.08 (26.88)
Search Engine Supply Index4.00 (0.95)

This Compound (25.26)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
thiophenes
Thiophenes: A monocyclic heteroarene furan in which the oxygen atom is replaced by a sulfur.. thiophenes : Compounds containing at least one thiophene ring.		3.4970mancude organic heteromonocyclic parent;
monocyclic heteroarene;
thiophenes;
volatile organic compound		non-polar solvent
isoxazoles
Isoxazoles: Azoles with an OXYGEN and a NITROGEN next to each other at the 1,2 positions, in contrast to OXAZOLES that have nitrogens at the 1,3 positions.. isoxazole : A monocyclic heteroarene with a structure consisting of a 5-membered ring containing three carbon atoms and an oxygen and nitrogen atom adjacent to each other. It is the parent of the class of isoxazoles.. isoxazoles : Oxazoles in which the N and O atoms are adjacent.		3.4970isoxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
clay
Clay: A naturally-occurring rock or soil constituent characterized by particles with a diameter of less than 0.005 mm. It is composed primarily of hydrous aluminum silicates, trace amounts of metal OXIDES, and organic matter.		2.2510
ConditionIndicatedRelationship StrengthStudiesTrials
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		02.1110
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.		02.1110
Weight Gain
Increase in BODY WEIGHT over existing weight.		02.1110