Compounds > melanotan-1

Page last updated: 2024-11-12

melanotan-1

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Cross-References

ID Source	ID
PubMed CID	16197727
MeSH ID	M0089943

Synonyms (15)

Synonym
alpha-ndp-msh
[nle4,dphe7]alpha-msh
gtpl1324
NCGC00167334-01
afamelanotide (usan/inn)
D10511
melanotan 1
DB04931
bdbm50017181
Q410794
DTXSID40226843 ,
(nle4,dphe7)alpha-msh
d02bb02
dtxcid70149334
AKOS040763896

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

Role	Description
dermatologic drug	A drug used to treat or prevent skin disorders or for the routine care of skin.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

Class	Description
polypeptide	A peptide containing ten or more amino acid residues.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (7)

Assay ID	Title	Year	Journal	Article
AID1346180	Human MC5 receptor (Melanocortin receptors)	2002	European journal of pharmacology, Apr-12, Volume: 440, Issue:2-3	The role of melanocortins in body weight regulation: opportunities for the treatment of obesity.
AID1346171	Human MC4 receptor (Melanocortin receptors)	1999	European journal of pharmacology, Aug-13, Volume: 378, Issue:3	Characterization of melanocortin receptor ligands on cloned brain melanocortin receptors and on grooming behavior in the rat.
AID1346178	Human MC3 receptor (Melanocortin receptors)	1999	European journal of pharmacology, Aug-13, Volume: 378, Issue:3	Characterization of melanocortin receptor ligands on cloned brain melanocortin receptors and on grooming behavior in the rat.
AID1346231	Human MC1 receptor (Melanocortin receptors)	1988	Endocrine reviews, Feb, Volume: 9, Issue:1	Proopiomelanocortin processing in the pituitary, central nervous system, and peripheral tissues.
AID1346171	Human MC4 receptor (Melanocortin receptors)	1980	Proceedings of the National Academy of Sciences of the United States of America, Oct, Volume: 77, Issue:10	4-Norleucine, 7-D-phenylalanine-alpha-melanocyte-stimulating hormone: a highly potent alpha-melanotropin with ultralong biological activity.
AID1346231	Human MC1 receptor (Melanocortin receptors)	2002	European journal of pharmacology, Apr-12, Volume: 440, Issue:2-3	The role of melanocortins in body weight regulation: opportunities for the treatment of obesity.
AID1346171	Human MC4 receptor (Melanocortin receptors)	2000	Biochemistry, Dec-05, Volume: 39, Issue:48	Molecular determinants of ligand binding to the human melanocortin-4 receptor.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	2 (40.00)	18.7374
1990's	1 (20.00)	18.2507
2000's	2 (40.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	2 (40.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	3 (60.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
melanotan-ii melanotan-II: synthetic cyclic heptapeptide, an analog of alpha-melanotropin (4,10); capable of stimulating melanin synthesis & promoting rapid tanning of skin; currently in trials for use in the prevention of sunlight-induced skin cancer	3.79	3	0	organic molecular entity
shu 9119 SHU 9119: an agouti mimetic; structure in first source	3.51	2	0

Condition	Indicated	Relationship Strength	Studies	Trials
Malignant Melanoma [description not available]	0	1.95	1	0
Melanoma A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)	0	1.95	1	0
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	0	2.92	1	0
Obesity A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).	0	2.92	1	0