Isosalsoline is a naturally occurring tetrahydroisoquinoline alkaloid found in plants such as Papaver somniferum (opium poppy). It has been shown to exhibit pharmacological activity, including potential antidepressant effects. Its synthesis has been explored, and it has been studied as a potential lead compound for the development of new therapeutic agents. However, research on isosalsoline is still relatively limited, and further investigations are needed to fully understand its potential applications.'
isosalsoline: RN given refers to parent cpd; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
ID Source | ID |
---|---|
PubMed CID | 46697 |
CHEMBL ID | 555908 |
CHEMBL ID | 1196096 |
CHEBI ID | 125375 |
MeSH ID | M0051869 |
Synonym |
---|
isosalsoline |
nsc-131726 |
nsc131726 |
OPREA1_046617 |
CHEBI:125375 |
HMS1648I04 |
6-methoxy-1-methyl-1,2,3,4-tetrahydroisoquinolin-7-ol |
chembl555908 , |
bdbm50014657 |
6-methoxy-1-methyl-1,2,3,4-tetrahydro-isoquinolin-7-ol; hydrochloride ((+/-)-isosalsoline) |
AKOS004907029 |
CHEMBL1196096 |
CCG-202812 |
4593-97-9 |
1,2,3,4-tetrahydro-6-methoxy-1-methyl-7-isoquinolinol |
7-hydroxy-6-methoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline |
nsc 131726 |
BRD-A20862232-001-01-4 |
1-methyl-6-methoxy-7-hydroxy-tetrahydroisochinolin |
CBMULJVNWNTWJM-UHFFFAOYSA-N |
6-methoxy-1-methyl-1,2,3,4-tetrahydro-7-isoquinolinol # |
Q27215760 |
DTXSID40963463 |
Class | Description |
---|---|
isoquinolines | A class of organic heteropolycyclic compound consisting of isoquinoline and its substitution derivatives. |
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID588519 | A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | 2011 | Antiviral research, Sep, Volume: 91, Issue:3 | High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. |
AID540299 | A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21 | Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 2 (40.00) | 18.7374 |
1990's | 1 (20.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 2 (40.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 5 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |