Page last updated: 2024-12-06

isosalsoline

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

Isosalsoline is a naturally occurring tetrahydroisoquinoline alkaloid found in plants such as Papaver somniferum (opium poppy). It has been shown to exhibit pharmacological activity, including potential antidepressant effects. Its synthesis has been explored, and it has been studied as a potential lead compound for the development of new therapeutic agents. However, research on isosalsoline is still relatively limited, and further investigations are needed to fully understand its potential applications.'

isosalsoline: RN given refers to parent cpd; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID46697
CHEMBL ID555908
CHEMBL ID1196096
CHEBI ID125375
MeSH IDM0051869

Synonyms (23)

Synonym
isosalsoline
nsc-131726
nsc131726
OPREA1_046617
CHEBI:125375
HMS1648I04
6-methoxy-1-methyl-1,2,3,4-tetrahydroisoquinolin-7-ol
chembl555908 ,
bdbm50014657
6-methoxy-1-methyl-1,2,3,4-tetrahydro-isoquinolin-7-ol; hydrochloride ((+/-)-isosalsoline)
AKOS004907029
CHEMBL1196096
CCG-202812
4593-97-9
1,2,3,4-tetrahydro-6-methoxy-1-methyl-7-isoquinolinol
7-hydroxy-6-methoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline
nsc 131726
BRD-A20862232-001-01-4
1-methyl-6-methoxy-7-hydroxy-tetrahydroisochinolin
CBMULJVNWNTWJM-UHFFFAOYSA-N
6-methoxy-1-methyl-1,2,3,4-tetrahydro-7-isoquinolinol #
Q27215760
DTXSID40963463
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
isoquinolinesA class of organic heteropolycyclic compound consisting of isoquinoline and its substitution derivatives.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (40.00)18.7374
1990's1 (20.00)18.2507
2000's0 (0.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]