Compounds > isosalsoline
Page last updated: 2024-12-06

isosalsoline

Description

Isosalsoline is a naturally occurring tetrahydroisoquinoline alkaloid found in plants such as Papaver somniferum (opium poppy). It has been shown to exhibit pharmacological activity, including potential antidepressant effects. Its synthesis has been explored, and it has been studied as a potential lead compound for the development of new therapeutic agents. However, research on isosalsoline is still relatively limited, and further investigations are needed to fully understand its potential applications.'

isosalsoline: RN given refers to parent cpd; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID46697
CHEMBL ID555908
CHEMBL ID1196096
CHEBI ID125375
MeSH IDM0051869

Synonyms (23)

Synonym
isosalsoline
nsc-131726
nsc131726
OPREA1_046617
CHEBI:125375
HMS1648I04
6-methoxy-1-methyl-1,2,3,4-tetrahydroisoquinolin-7-ol
chembl555908 ,
bdbm50014657
6-methoxy-1-methyl-1,2,3,4-tetrahydro-isoquinolin-7-ol; hydrochloride ((+/-)-isosalsoline)
AKOS004907029
CHEMBL1196096
CCG-202812
4593-97-9
1,2,3,4-tetrahydro-6-methoxy-1-methyl-7-isoquinolinol
7-hydroxy-6-methoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline
nsc 131726
BRD-A20862232-001-01-4
1-methyl-6-methoxy-7-hydroxy-tetrahydroisochinolin
CBMULJVNWNTWJM-UHFFFAOYSA-N
6-methoxy-1-methyl-1,2,3,4-tetrahydro-7-isoquinolinol #
Q27215760
DTXSID40963463
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
isoquinolinesA class of organic heteropolycyclic compound consisting of isoquinoline and its substitution derivatives.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (40.00)18.7374
1990's1 (20.00)18.2507
2000's0 (0.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
reserpine
Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.. reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.		1.9510alkaloid ester;
methyl ester;
yohimban alkaloid		adrenergic uptake inhibitor;
antihypertensive agent;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
environmental contaminant;
first generation antipsychotic;
plant metabolite;
xenobiotic
1,2,3,4-tetrahydroisoquinoline
1,2,3,4-tetrahydroisoquinoline: RN given refers to cpd with locants as specified		1.9510isoquinolines
salsolidine
salsolidine: RN given refers to parent cpd without isomeric designation		710isoquinolines
3,4-dihydroxybenzylamine
3,4-dihydroxybenzylamine: RN given refers to parent cpd; structure		1.9510catechols
ConditionIndicatedRelationship StrengthStudiesTrials
Encephalitis, Polio
[description not available]		02.0610
Poliomyelitis
An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)		02.0610
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