howiinol A: isolated from Goniothalamus howii; structure in first source; do not confuse with GHM-10, gas hypoxic mixture of 90% N2 & 10% O2 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 6440329 |
| CHEMBL ID | 1170578 |
| MeSH ID | M0387966 |
| Synonym |
|---|
| howiinol a |
| CHEMBL1170578 |
| [(1r,2r)-2-hydroxy-2-[(2r,3s)-3-hydroxy-6-oxo-2,3-dihydropyran-2-yl]-1-phenylethyl] (e)-3-phenylprop-2-enoate |
| 190848-69-2 |
| d-xylo-hept-2-enonic acid, 2,3-dideoxy-7-c-phenyl-, delta-lactone, 7-((2e)-3-phenyl-2-propenoate), (7r)- |
Howiinol A (GHM-10) is a kind of phenylethylene pyrone compounds isolated from Goniothalamus howii.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Howiinol A (GHM-10) is a kind of phenylethylene pyrone compounds isolated from Goniothalamus howii. " | ( Anticancer effect of Howiinol A and its mechanism of action. He, JH; Xu, CX, 1999) | 2.07 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID490143 | Cytotoxicity against human KB cells after 24 hrs | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and cytotoxic activity of fluorinated analogues of Goniothalamus lactones. Impact of fluorine on oxidative processes. |
| AID490144 | Cytotoxicity against human MCF7 cells after 24 hrs | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and cytotoxic activity of fluorinated analogues of Goniothalamus lactones. Impact of fluorine on oxidative processes. |
| AID490146 | Cytotoxicity against human HepG2 cells after 24 hrs | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and cytotoxic activity of fluorinated analogues of Goniothalamus lactones. Impact of fluorine on oxidative processes. |
| AID490145 | Cytotoxicity against human HT-29 cells after 24 hrs | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and cytotoxic activity of fluorinated analogues of Goniothalamus lactones. Impact of fluorine on oxidative processes. |
| AID490147 | Cytotoxicity against human A549 cells after 24 hrs | 2010 | European journal of medicinal chemistry, Jul, Volume: 45, Issue:7 | Synthesis and cytotoxic activity of fluorinated analogues of Goniothalamus lactones. Impact of fluorine on oxidative processes. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (85.71) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.10) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 7 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||