howiinol-a has been researched along with goniothalamin* in 1 studies
1 other study(ies) available for howiinol-a and goniothalamin
| Article | Year |
|---|---|
Synthesis and cytotoxic activity of fluorinated analogues of Goniothalamus lactones. Impact of fluorine on oxidative processes.
Novel fluorinated analogues of goniothalamin 1 and howiinol A 2 have been prepared from trifluorocrotonate derivatives. Trifluoromethyl goniothalamin (R/S) 4 showed a slightly lower activity than 1, while the trifluoromethyl howiinol A 16 exhibited similar activities on several cell lines in the micromolar range. Unlike (R) goniothalamin and howiinol A, trifluoromethyl parent compounds remained unchanged when submitted to biomimetic oxidative systems. Topics: Antineoplastic Agents; Cell Line, Tumor; Fluorine; Goniothalamus; Humans; Inhibitory Concentration 50; Lactones; Oxidation-Reduction; Pyrones; Structure-Activity Relationship | 2010 |