Page last updated: 2024-11-12

haloxyfop-P-methyl

Description

haloxyfop-P-methyl : A methyl 2-(4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoate that has R configuration. It is a proherbicide (by hydrolysis of the methyl ester) for the herbicide haloxyfop-P, the most active enantiomer of the racemic herbicide haloxyfop. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID13363033
CHEMBL ID2286458
CHEBI ID136729
SCHEMBL ID54814

Synonyms (40)

Synonym
edge
methyl (2r)-2-[4-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]oxy]phenoxy]propanoate
(r)-haloxyfop methyl ester
methyl (r)-2-{4-[3-chloro-5-(trifluoromethyl)-2-pyridyloxy]phenoxy}propionate
haloxyfop-p-methyl
gallant super
72619-32-0
CHEBI:136729
methyl (2r)-2-(4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propionate
methyl (2r)-2-(4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoate
eloge
de 535
zellek super
unii-7vd796hhts
methyl (r)-2-(4-(3-chloro-5-trifluoromethyl-2-pyridyloxy)phenoxy)propionate
haloxyfop-p-methyl [iso]
7vd796hhts ,
ec 406-250-0
(r)-methyl 2-(4-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)phenoxy)propanoate
c16h13clf3no4
AKOS015895898
propanoic acid, 2-(4-((3-chloro-5-(trifluoromethyl)-2-pyridinyl)oxy)phenoxy)-, methyl ester, (2r)-
de-535
186673-58-5
SCHEMBL54814
CHEMBL2286458
DTXSID8058249
haloxyfop-p-methyl, pestanal(r), analytical standard
propanoic acid, 2-[4-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]oxy]phenoxy]-, methyl ester, (2r)-
haloxyfop-r-methyl 10 microg/ml in acetonitrile
methyl (r)-2-(4-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)phenoxy)propanoate
(r)-methyl 2-(4-((3-chloro-5-(trifluoromethyl)-pyridin-2-yl)oxy)phenoxy)propanoate
(r)-methyl 2-(4-(3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)phenoxy)propanoate
MFSWTRQUCLNFOM-SECBINFHSA-N ,
haloxyfop-(r)-methyl
AS-13063
methyl (2r)-2-[4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxyphenoxy]propanoate
Q27268911
CS-0128835
HY-136374

Research Excerpts

Toxicity

ExcerptReferenceRelevance
"Haloxyfop-P-methyl is used extensively in agricultural production, and its metabolites in soil have potentially toxic effects on aquatic ecosystems."( Haloxyfop-P-methyl induces immunotoxicity and glucose metabolism disorders and affects the Nrf2/ARE pathway mediated antioxidant system in Chiromantes dehaani.
Du, X; Li, Y; Liu, Z; Tian, J; Xu, W; Yang, Y; Ye, Y; Zhao, Y, 2023
)
3.8
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (3)

RoleDescription
proherbicideA compound that, on administration, must undergo chemical conversion by biochemical (enzymatic), chemical (possibly following an enzymatic step), or physical (e.g. photochemical) activation processes before becoming the pharmacologically active herbicide for which it is a proherbicide.
EC 6.4.1.2 (acetyl-CoA carboxylase) inhibitorAn EC 6.4.1.* (C-C bond-forming ligase) inhibitor that interferes with the action of acetyl-CoA carboxylase (EC 6.4.1.2).
agrochemicalAn agrochemical is a substance that is used in agriculture or horticulture.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
methyl 2-(4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoateThe methyl ester of 2-(4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoic acid.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (12)

Assay IDTitleYearJournalArticle
AID1111576Herbicidal activity against Sorghum bicolor assessed as inhibitory rate of fresh weight gain at 7.5 g/hm'2 relative to control2010Carbohydrate research, Sep-03, Volume: 345, Issue:13
Novel 2'-hydroxylfurylchalcones: synthesis and biological activity.
AID1111579Herbicidal activity against Triticum aestivum (wheat) assessed as inhibitory rate of seedling height at 7.5 g/hm'2 relative to control2010Carbohydrate research, Sep-03, Volume: 345, Issue:13
Novel 2'-hydroxylfurylchalcones: synthesis and biological activity.
AID1111578Herbicidal activity against Triticum aestivum (wheat) assessed as inhibitory rate of fresh weight gain at 7.5 g/hm'2 relative to control2010Carbohydrate research, Sep-03, Volume: 345, Issue:13
Novel 2'-hydroxylfurylchalcones: synthesis and biological activity.
AID1111584Herbicidal activity against Cucumis sativus (cucumber) assessed as inhibitory rate of fresh weight gain at 7.5 g/hm'2 relative to control2010Carbohydrate research, Sep-03, Volume: 345, Issue:13
Novel 2'-hydroxylfurylchalcones: synthesis and biological activity.
AID1111574Herbicidal activity against Dinebra chinensis assessed as inhibitory rate of seedling height at 7.5 g/hm'2 relative to control2010Carbohydrate research, Sep-03, Volume: 345, Issue:13
Novel 2'-hydroxylfurylchalcones: synthesis and biological activity.
AID1111585Herbicidal activity against Cucumis sativus (cucumber) assessed as inhibitory rate of seedling height at 7.5 g/hm'2 relative to control2010Carbohydrate research, Sep-03, Volume: 345, Issue:13
Novel 2'-hydroxylfurylchalcones: synthesis and biological activity.
AID1111583Herbicidal activity against Brassica rapa subsp. oleifera assessed as inhibitory rate of seedling height at 7.5 g/hm'2 relative to control2010Carbohydrate research, Sep-03, Volume: 345, Issue:13
Novel 2'-hydroxylfurylchalcones: synthesis and biological activity.
AID1111577Herbicidal activity against Sorghum bicolor assessed as inhibitory rate of seedling height at 7.5 g/hm'2 relative to control2010Carbohydrate research, Sep-03, Volume: 345, Issue:13
Novel 2'-hydroxylfurylchalcones: synthesis and biological activity.
AID1111582Herbicidal activity against Brassica rapa subsp. oleifera assessed as inhibitory rate of fresh weight gain at 7.5 g/hm'2 relative to control2010Carbohydrate research, Sep-03, Volume: 345, Issue:13
Novel 2'-hydroxylfurylchalcones: synthesis and biological activity.
AID1111581Herbicidal activity against Amaranthus tricolor assessed as inhibitory rate of seedling height at 7.5 g/hm'2 relative to control2010Carbohydrate research, Sep-03, Volume: 345, Issue:13
Novel 2'-hydroxylfurylchalcones: synthesis and biological activity.
AID1111580Herbicidal activity against Amaranthus tricolor assessed as inhibitory rate of fresh weight gain at 7.5 g/hm'2 relative to control2010Carbohydrate research, Sep-03, Volume: 345, Issue:13
Novel 2'-hydroxylfurylchalcones: synthesis and biological activity.
AID1111575Herbicidal activity against Dinebra chinensis assessed as inhibitory rate of fresh weight gain at 7.5 g/hm'2 relative to control2010Carbohydrate research, Sep-03, Volume: 345, Issue:13
Novel 2'-hydroxylfurylchalcones: synthesis and biological activity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (20.00)24.3611
2020's4 (80.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 39.00

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index39.00 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.36 (4.65)
Search Engine Demand Index73.92 (26.88)
Search Engine Supply Index2.93 (0.95)

This Compound (39.00)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
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