Compounds > glyfoline
Page last updated: 2024-12-11

glyfoline

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

glyfoline: structure given in first source; isolated from Glycosmis citrifolia [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
Glycosmisgenus[no description available]RutaceaeA plant family in the order Sapindales that grows in warmer regions and has conspicuous flowers.[MeSH]

Cross-References

ID SourceID
PubMed CID5480208
CHEMBL ID88259
SCHEMBL ID9348448
MeSH IDM0204104

Synonyms (9)

Synonym
CHEMBL88259
glyfoline
82354-35-6
1,6-dihydroxy-2,3,4,5-tetramethoxy-10-methyl-acridin-9-one
1,6-dihydroxy-10-methyl-2,3,4,5-tetramethoxyacridin-9-one
9(10h)-acridinone, 1,6-dihydroxy-2,3,4,5-tetramethoxy-10-methyl-
DTXSID50231706
SCHEMBL9348448
1,6-dihydroxy-2,3,4,5-tetramethoxy-10-methylacridin-9(10h)-one
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID1446673Antiproliferative activity against human HL60 cells
AID89338Ability to inhibit human leukemic HL-60 cell growth in culture1992Journal of medicinal chemistry, Jul-10, Volume: 35, Issue:14
Synthesis of the acridone alkaloids glyfoline and congeners. Structure-activity relationship studies of cytotoxic acridones.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (4)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (25.00)18.2507
2000's1 (25.00)29.6817
2010's2 (50.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
acridone
acridone : A member of the class of acridines that is 9,10-dihydroacridine substituted by an oxo group at position 9.		6.9810acridines;
cyclic ketone
acridines
Acridines: Compounds that include the structure of acridine.. acridine : A polycyclic heteroarene that is anthracene in which one of the central CH groups is replaced by a nitrogen atom.		2.730acridines;
mancude organic heterotricyclic parent;
polycyclic heteroarene		genotoxin
acronine
Acronine: A pyrano-acridone alkaloid found in RUTACEAE plants.. acronycine : An alkaloid antineoplastic agent isolated from Acronychia baueri.		1.9810acridone derivatives;
alkaloid		antineoplastic agent;
metabolite
cytochrome c-t
Cytochromes c: Cytochromes of the c type that are found in eukaryotic MITOCHONDRIA. They serve as redox intermediates that accept electrons from MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III and transfer them to MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX IV.		2.0210
ConditionIndicatedRelationship StrengthStudiesTrials
Adenocarcinoma, Basal Cell
[description not available]		02.0510
Cancer of Lung
[description not available]		02.0510
Benign Neoplasms
[description not available]		02.0510
Cancer of Prostate
[description not available]		02.0510
Adenocarcinoma
A malignant epithelial tumor with a glandular organization.		02.0510
Lung Neoplasms
Tumors or cancer of the LUNG.		02.0510
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.0510
Prostatic Neoplasms
Tumors or cancer of the PROSTATE.		02.0510
Cancer of Nasopharynx
[description not available]		02.0210
Nasopharyngeal Neoplasms
Tumors or cancer of the NASOPHARYNX.		02.0210