glyfoline and Nasopharyngeal-Neoplasms

glyfoline has been researched along with Nasopharyngeal-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for glyfoline and Nasopharyngeal-Neoplasms

Article	Year
Cytochrome C release induces apoptosis of nasopharyngeal carcinoma (NPC) by antitumor glyfoline. Planta medica, 2005, Volume: 71, Issue:1 The mechanism of action, leakage of cytochrome c from mitochondria into cytosol, for the antineoplastic compound glyfoline was examined. Additionally, our current studies revealed that glyfoline induced apoptotic changes and arrested cell cycle procession at the G2/M phase in nasopharyngeal carcinoma (NPC). A reverse transcriptase polymerase chain reaction (RT-PCR) showed no specific changes of apoptosis-related gene expression (i. e., bax, ICE-alpha,beta, bcl-2, and c-myc). However, no similar changes were detected in fibroblasts and peripheral lymphocytes after glyfoline treatment suggesting that glyfoline has a higher affinity for tumor cells than for normal cells. Topics: Acridines; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Cytochromes c; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Inhibitory Concentration 50; Mitochondria; Nasopharyngeal Neoplasms; Phytotherapy; Plant Extracts; Reverse Transcriptase Polymerase Chain Reaction; Rutaceae	2005

Article

Year

Cytochrome C release induces apoptosis of nasopharyngeal carcinoma (NPC) by antitumor glyfoline.

Planta medica, 2005, Volume: 71, Issue:1

The mechanism of action, leakage of cytochrome c from mitochondria into cytosol, for the antineoplastic compound glyfoline was examined. Additionally, our current studies revealed that glyfoline induced apoptotic changes and arrested cell cycle procession at the G2/M phase in nasopharyngeal carcinoma (NPC). A reverse transcriptase polymerase chain reaction (RT-PCR) showed no specific changes of apoptosis-related gene expression (i. e., bax, ICE-alpha,beta, bcl-2, and c-myc). However, no similar changes were detected in fibroblasts and peripheral lymphocytes after glyfoline treatment suggesting that glyfoline has a higher affinity for tumor cells than for normal cells.

Topics: Acridines; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Cytochromes c; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Inhibitory Concentration 50; Mitochondria; Nasopharyngeal Neoplasms; Phytotherapy; Plant Extracts; Reverse Transcriptase Polymerase Chain Reaction; Rutaceae

2005