gamma-coniceine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

gamma-coniceine: isolated from seeds of Conium maculatum (poison hemlock); structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Flora	Rank	Flora Definition	Family	Family Definition
Conium	genus	A plant genus of the family APIACEAE that is a source of coniine.[MeSH]	Apiaceae	A large plant family in the order Apiales, also known as Umbelliferae. Most are aromatic herbs with alternate, feather-divided leaves that are sheathed at the base. The flowers often form a conspicuous flat-topped umbel. Each small individual flower is usually bisexual, with five sepals, five petals, and an enlarged disk at the base of the style. The fruits are ridged and are composed of two parts that split open at maturity.[MeSH]
Conium maculatum	species	Conium maculatum is a large toxic umbelliferous plant, which contains the alkaloid coniine which affects the nervous system. The dried, fully grown, unripe fruit has sedative, anodyne, and antispasmodic effects.[MeSH]	Apiaceae	A large plant family in the order Apiales, also known as Umbelliferae. Most are aromatic herbs with alternate, feather-divided leaves that are sheathed at the base. The flowers often form a conspicuous flat-topped umbel. Each small individual flower is usually bisexual, with five sepals, five petals, and an enlarged disk at the base of the style. The fruits are ridged and are composed of two parts that split open at maturity.[MeSH]

Cross-References

ID Source	ID
PubMed CID	442632
CHEBI ID	10561
SCHEMBL ID	1760704
MeSH ID	M0133442

Synonyms (28)

Synonym
2-propyl-3,4,5,6-tetrahydro-pyridine
pyridine, 2,3,4,5-tetrahydro-6-propyl-
brn 0106092
gamma-conicein
2,3,4,5-tetrahydro-6-propylpyridine
gamma-coniceine
1604-01-9
6-propyl-2,3,4,5-tetrahydropyridine
AKOS006277083
unii-phk73qlk4z
phk73qlk4z ,
5-20-04-00345 (beilstein handbook reference)
2-n-propyl-3,4,5,6-tetrahydropyridine
.gamma.-coniceine
2-n-propyl-.delta.-piperidine
coniceine, gamma-
.gamma.-coniceine [mi]
SCHEMBL1760704
CHEBI:10561
PQSOVRNZJIENNW-UHFFFAOYSA-N
6-propyl-2,3,4,5-tetrahydropyridine #
.gamma.-conicein
2-propyl-3,4,5,6-tetrahydropyridine
DTXSID00166872
6-propyl-2,3,4,5-tetrahydro-pyridine
Q27108656
BAA60401
EN300-219505

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

Class	Description
tetrahydropyridine
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (6)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (16.67)	18.7374
1990's	3 (50.00)	18.2507
2000's	1 (16.67)	29.6817
2010's	1 (16.67)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 22.15

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	22.15 (24.57)
Research Supply Index	1.95 (2.92)
Research Growth Index	4.80 (4.65)
Search Engine Demand Index	18.60 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (22.15)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	2 (33.33%)	4.05%
Observational	0 (0.00%)	0.25%
Other	4 (66.67%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
coniine coniine: alkaloid isolated from Conium maculatum L.; properties as an analgesics, antineuralgic, & teratogen; RN given refers to parent cpd without isomeric designation; structure	2.89	4
anabasine Anabasine: A piperidine botanical insecticide.. (S)-anabasine : The (S)-enantiomer of anabasine.. anabasine : A pyridine alkaloid that is pyridine substituted by a piperidin-2-yl group at position 3.	1.97	1	anabasine
ammodendrine ammodendrine: structure given in first source; RN given refers to (R)-isomer. ammodendrine : A piperidine alkaloid that is piperidine substituted by a 1-acetyl-1,4,5,6-tetrahydropyridin-3-yl group at position 2 (the 2R-stereoisomer).	1.97	1	acetamides; N-acylpiperidine; piperidine alkaloid	plant metabolite; teratogenic agent
piperidines Piperidines: A family of hexahydropyridines.	2.89	4

Condition	Relationship Strength	Studies
Plant Poisoning Poisoning by the ingestion of plants or its leaves, berries, roots or stalks. The manifestations in both humans and animals vary in severity from mild to life threatening. In animals, especially domestic animals, it is usually the result of ingesting moldy or fermented forage.	2.89	4
Abnormalities, Multiple Congenital abnormalities that affect more than one organ or body structure.	1.97	1
Cleft Palate, Isolated [description not available]	2.37	2
Caprine Diseases [description not available]	1.97	1
Cleft Palate Congenital fissure of the soft and/or hard palate, due to faulty fusion.	2.37	2
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	2.37	2
Complications, Pregnancy [description not available]	1.96	1
Swine Diseases Diseases of domestic swine and of the wild boar of the genus Sus.	1.96	1

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