Flordipine is a dihydropyridine calcium channel blocker. It is a potent and selective blocker of L-type calcium channels, which are found in the heart, smooth muscle, and other tissues. Flordipine is used to treat hypertension and angina. It is also being studied for its potential use in treating other conditions, such as Alzheimer's disease and cancer. Flordipine is synthesized via a multi-step process involving the reaction of an appropriate pyridine derivative with an alkyl halide, followed by a series of reactions to form the desired dihydropyridine ring system. Flordipine is known to relax blood vessels and reduce blood pressure by blocking the influx of calcium ions into smooth muscle cells. Its importance lies in its ability to treat hypertension and angina, contributing to improving the lives of patients with these conditions. Studies of flordipine are ongoing to understand its potential applications beyond treating hypertension and angina, including its effects on neurodegenerative diseases and cancer. '
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| ID Source | ID |
|---|---|
| PubMed CID | 53699 |
| CHEMBL ID | 2107262 |
| CHEBI ID | 177726 |
| SCHEMBL ID | 124041 |
| MeSH ID | M0125134 |
| Synonym |
|---|
| diethyl 2,6-dimethyl-1-(2-morpholin-4-ylethyl)-4-[2-(triluoromethyl)phenyl]-4h-pyridine-3,5-dicarboxylate |
| CHEBI:177726 |
| 77590-96-6 |
| D04193 |
| flordipine (usan/inn) |
| rhc-2906 |
| flordipine |
| diethyl 2,6-dimethyl-1-(2-morpholin-4-ylethyl)-4-[2-(trifluoromethyl)phenyl]-4h-pyridine-3,5-dicarboxylate |
| flordipine [usan:inn] |
| 3,5-pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-1-(2-(4-morpholinyl)ethyl)-4-(2-(trifluoromethyl)phenyl)-, diethyl ester |
| z8ufi7xi7r , |
| rhc 2906 |
| flordipino [spanish] |
| flordipino |
| diethyl 1,4-dihydro-2,6-dimethyl-1-(2-morpholinoethyl)-4-(alpha,alpha,alpha-trifluoro-o-tolyl)3,5-pyridinedicarboxylate |
| flordipinum |
| unii-z8ufi7xi7r |
| flordipinum [latin] |
| CHEMBL2107262 |
| SCHEMBL124041 |
| flordipine [usan] |
| flordipine [who-dd] |
| flordipine [inn] |
| diethyl 1,4-dihydro-2,6-dimethyl-1-(2-(4-morpholinyl)ethyl)-4-(2-(trifluoromethyl)phenyl)-3,5-pyridinedicarboxylate |
| diethyl 1,4-dihydro-4-(2-trifluoromethylphenyl)-2,6-dimethyl-1-(2-morpholinoethyl)-3,5-pyridinedicarboxylate |
| diethyl 1,4-dihydro-2,6-dimethyl-1-[2-(4-morpholinyl)ethyl]-4-[2-(trifluoromethyl)phenyl]-3,5-pyridinedicarboxylate |
| Q27295152 |
| diethyl 2,6-dimethyl-1-(2-morpholinoethyl)-4-(2-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3,5-dicarboxylate |
| DTXSID60868446 |
| AKOS040746832 |
| Class | Description |
|---|---|
| (trifluoromethyl)benzenes | An organofluorine compound that is (trifluoromethyl)benzene and derivatives arising from substitution of one or more of the phenyl hydrogens. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 5 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (17.69) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 1 (20.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 4 (80.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||