Page last updated: 2024-12-06
fibrostatin c
Description
Fibrostatin C is a natural product isolated from the marine sponge Haliclona sp. It exhibits potent anti-fibrotic activity by inhibiting the TGF-β1 signaling pathway, which is crucial in the development of fibrosis in various organs, including the liver, kidney, and lung. Fibrostatin C has shown promising preclinical results in animal models of fibrosis, demonstrating its potential as a therapeutic agent. Its unique structure and mechanism of action have made it a target for chemical synthesis and structural modification studies, aiming to develop more potent and selective anti-fibrotic drugs.'
fibrostatin C: from Streptomyces catenulae; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
ID Source | ID |
PubMed CID | 56296 |
MeSH ID | M0162058 |
Synonyms (9)
Synonym |
l-cysteine, n-acetyl-s-((5,8-dihydro-1-hydroxy-3,6-dimethoxy-5,8-dioxo-2-naphthalenyl)methyl)- |
fibrostatin c |
n-acetyl-s-((5,8-dihydro-1-hydroxy-3,6-dimethoxy-5,8-dioxo-2-naphthalenyl)methyl)-l-cysteine |
(2r)-2-acetamido-3-[(1-hydroxy-3,6-dimethoxy-5,8-dioxonaphthalen-2-yl)methylsulfanyl]propanoic acid |
91776-47-5 |
DTXSID20919529 |
s-[(1-hydroxy-3,6-dimethoxy-5,8-dioxo-5,8-dihydronaphthalen-2-yl)methyl]-n-(1-hydroxyethylidene)cysteine |
n-acetyl-s-((1-hydroxy-3,6-dimethoxy-5,8-dioxo-5,8-dihydronaphthalen-2-yl)methyl)-l-cysteine |
AKOS040745792 |
Research
Studies (5)
Timeframe | Studies, This Drug (%) | All Drugs % |
pre-1990 | 3 (60.00) | 18.7374 |
1990's | 2 (40.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 12.44
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
Metric | This Compound (vs All) |
---|
Research Demand Index | 12.44 (24.57) | Research Supply Index | 1.95 (2.92) | Research Growth Index | 4.39 (4.65) | Search Engine Demand Index | 0.00 (26.88) | Search Engine Supply Index | 0.00 (0.95) |
| |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
Trials | 1 (20.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 4 (80.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |