dihydronitidine: molecular structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 99641 |
| CHEMBL ID | 487807 |
| SCHEMBL ID | 11749474 |
| MeSH ID | M0211857 |
| Synonym |
|---|
| dihydronitidine |
| NSC254666 , |
| nsc-254666 |
| 13063-06-4 |
| nitidine, dihydro |
| [1,6-c]phenanthridine, 12,13-dihydro-2,3-dimethoxy-12-methyl- |
| nitidine, dihydro- |
| c21h19no4 |
| 2,3-dimethoxy-12-methyl-13h-[1,3]benzodioxolo[5,6-c]phenanthridine |
| CHEMBL487807 |
| 5,6-dihydronitidine |
| (1,3)benzodioxolo(5,6-c)phenanthridine, 12,13-dihydro-2,3-dimethoxy-12-methyl- |
| nsc 254666 |
| SCHEMBL11749474 |
| MTVOSXTZNVKGIF-UHFFFAOYSA-N |
| 2,3-dimethoxy-12-methyl-12,13-dihydro[1,3]benzodioxolo[5,6-c]phenanthridine # |
| [1,3]benzodioxolo[5,6-c]phenanthridine, 12,13-dihydro-2,3-dimethoxy-12-methyl- |
| DTXSID20156654 |
| 12,13-dihydro-2,3-dimethoxy-12-methyl-(1,3)benzodioxolo(5,6-c)phenanthridine |
| Excerpt | Reference | Relevance |
|---|---|---|
| "To develop a novel anti-cancer drug of low side effect against lung adenocarcinoma, the authors screened the bioresources of Okinawa Island, Japan." | ( Tumor-selective cytotoxicity of benzo[c]phenanthridine derivatives from Toddalia asiatica Lam. Iwasaki, H; Okabe, T; Oku, H; Shimatani, M; Takara, K; Toda, T, 2010) | 0.36 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1698175 | Inhibition of anti-human CD3/CD28/mAbs-stimulated human T-cell proliferation after 72 hrs by CFSE staining based flow cytometric analysis | |||
| AID338342 | In vivo antitumor activity against mouse P388 cells at 30 to 50 mg/kg, ip relative to control | |||
| AID1236963 | Antiproliferative activity against human HL60 cells assessed as inhibition of cell viability after 48 hrs by WST-1 assay | 2015 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 25, Issue:14 | Antiproliferative activity of O4-benzo[c]phenanthridine alkaloids against HCT-116 and HL-60 tumor cells. |
| AID1236962 | Antiproliferative activity against human HCT116 cells assessed as inhibition of cell viability after 48 hrs by MTT assay | 2015 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 25, Issue:14 | Antiproliferative activity of O4-benzo[c]phenanthridine alkaloids against HCT-116 and HL-60 tumor cells. |
| AID1698177 | Cytotoxicity against human T-cell assessed reduction in cell viability at 30 uM after 72 hrs | |||
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.60) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||