Compounds > damsin
Page last updated: 2024-12-05

damsin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

damsin: from Ambrosia maritima; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
AmbrosiagenusA plant genus of the family ASTERACEAE. The POLLEN is one cause of HAYFEVER.[MeSH]AsteraceaeA large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of daisy refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.[MeSH]

Cross-References

ID SourceID
PubMed CID14631
CHEMBL ID2286469
CHEBI ID4314
SCHEMBL ID18642932
MeSH IDM0059184

Synonyms (18)

Synonym
azuleno(4,5-b)furan-2,9-dione, decahydro-6,9a-dimethyl-3-methylene-, (3as-(3aalpha,6beta,6aalpha,9abeta,9balpha))-
decahydro-6,9a-dimethyl-3-methylene-azuleneo(4,5-b)furan-2,9-dione
10-alpha-h-ambros-11(13)-en-12-oic acid, 6-beta-hydroxy-4-oxo-, gamma-lactone
10alphah-ambros-11(13)-en-12-oic acid, 6beta-hydroxy-4-oxo-, gamma-lactone
azulene derivative
nsc-85249
azuleno[4,9-dione, decahydro-6,9a-dimethyl-3-methylene-, [3as-(3a.alpha.,6.beta.,6a.alpha.,9a.beta.,9b.alpha.)]-
10.alpha.h-ambros-11(13)-en-12-oic acid, .gamma.-lactone
1216-42-8
damsin
C09386
(3as,6s,6as,9ar,9br)-6,9a-dimethyl-3-methylidene-3a,4,5,6,6a,7,8,9b-octahydroazuleno[8,7-b]furan-2,9-dione
chebi:4314 ,
CHEMBL2286469
SCHEMBL18642932
DTXSID70923878
6,9a-dimethyl-3-methylidenedecahydroazuleno[4,5-b]furan-2,9-dione
Q27106332

Research Excerpts

Treatment

Damsin and ambrosin treatment increased the number of micronuclei. Another sign of DNA damage was the increased level of p53. Treatment decreased the CSC subpopulation and inhibited cell migration.

ExcerptReferenceRelevance
"Damsin and ambrosin treatment increased the number of micronuclei; moreover, another sign of DNA damage was the increased level of p53."( Anti-cancer stem cell activity of a sesquiterpene lactone isolated from Ambrosia arborescens and of a synthetic derivative.
Almanza, G; Huang, X; Kempengren, S; Malakpour, A; Oredsson, S; Rodrigo, G; Smiljanic, S; Sotillo, WS; Sterner, O; Villagomez, R, 2017)		1.18
"Treatment with damsin and ambrosin decreased the CSC subpopulation and inhibited cell migration."( Anti-cancer stem cell activity of a sesquiterpene lactone isolated from Ambrosia arborescens and of a synthetic derivative.
Almanza, G; Huang, X; Kempengren, S; Malakpour, A; Oredsson, S; Rodrigo, G; Smiljanic, S; Sotillo, WS; Sterner, O; Villagomez, R, 2017)		0.79

Dosage Studied

ExcerptRelevanceReference
" Inhibitory concentration 50 (IC50) values were obtained from dose-response curves."( Anti-cancer stem cell activity of a sesquiterpene lactone isolated from Ambrosia arborescens and of a synthetic derivative.
Almanza, G; Huang, X; Kempengren, S; Malakpour, A; Oredsson, S; Rodrigo, G; Smiljanic, S; Sotillo, WS; Sterner, O; Villagomez, R, 2017)		0.46
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
sesquiterpene lactoneAny member of a diverse class of complex, multicyclic phytochemicals showing a variety of skeleton arrangements and bioactivities, and having in common a sesquiterpenoid structure including a lactone ring.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (37.50)18.7374
1990's1 (12.50)18.2507
2000's0 (0.00)29.6817
2010's4 (50.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 41.84

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index41.84 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.84 (4.65)
Search Engine Demand Index56.82 (26.88)
Search Engine Supply Index2.03 (0.95)

This Compound (41.84)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
ambrosin
ambrosin: from Ambrosia maritime; structure		2.8740sesquiterpene lactone
confertin
confertin: structure. confertin : A pseudoguaianolide that is decahydroazuleno[6,5-b]furan-2(3H)-one substituted by an oxo group at position 5, methyl groups at positions 4a and 8 and a methylidene group at position 3. It has been isolated from the aerial parts of Inula hupehensis.		2.0510cyclic ketone;
gamma-lactone;
organic heterotricyclic compound;
pseudoguaianolide		anti-inflammatory agent;
metabolite;
plant metabolite
coronopilin
coronopilin: isolated from Ambrosia arborescens		7.5220sesquiterpene lactone
sesquiterpenes
[no description available]		3.4880
ConditionIndicatedRelationship StrengthStudiesTrials
Benign Neoplasms
[description not available]		02.0810
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.0810