Page last updated: 2024-11-11
cryptophycin 55
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
cryptophycin 55: chlorohydrin prodrug to cryptophycin 52 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 9896488 |
| CHEMBL ID | 263425 |
| SCHEMBL ID | 12092055 |
| MeSH ID | M0369977 |
Synonyms (7)
| Synonym |
|---|
| CHEMBL263425 |
| SCHEMBL12092055 |
| cryptophycin 55 |
| (3s,10r,13e,16s)-16-[(2r,3r,4s)-4-chloro-3-hydroxy-4-phenylbutan-2-yl]-10-[(3-chloro-4-methoxyphenyl)methyl]-6,6-dimethyl-3-(2-methylpropyl)-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone |
| MXZDFWPOJAPNJL-VIVUCZJBSA-N |
| 186256-69-9 |
| DTXSID501046680 |
Research Excerpts
Pharmacokinetics
| Excerpt | Reference | Relevance |
|---|---|---|
| " Pharmacokinetic parameters were computed using noncompartmental methods." | ( Pharmacokinetics and tissue distribution of cryptophycin 52 (C-52) epoxide and cryptophycin 55 (C-55) chlorohydrin in mice with subcutaneous tumors. Boinpally, RR; Corbett, TH; Horwitz, JP; Jasti, BR; Kushner, J; Parchment, RE; Polin, L; White, K; Wiegand, RA; Zhou, SL, 2003) | 0.55 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (14)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID111308 | In vivo antitumor activity against murine pancreatic adenocarcinoma and measured as number of deaths on a schedule of 5-10 day and at a total dose of 402 mg/kg | 2003 | Journal of medicinal chemistry, Jul-03, Volume: 46, Issue:14 | A convergent approach to cryptophycin 52 analogues: synthesis and biological evaluation of a novel series of fragment a epoxides and chlorohydrins. |
| AID124783 | In vivo antitumor activity against murine pancreatic adenocarcinoma and measured as % weight loss on a schedule of 5-10 day and at a total dose of 210 mg/kg | 2003 | Journal of medicinal chemistry, Jul-03, Volume: 46, Issue:14 | A convergent approach to cryptophycin 52 analogues: synthesis and biological evaluation of a novel series of fragment a epoxides and chlorohydrins. |
| AID124784 | In vivo antitumor activity against murine pancreatic adenocarcinoma and measured as % weight loss on a schedule of 5-10 day and at a total dose of 270 mg/kg | 2003 | Journal of medicinal chemistry, Jul-03, Volume: 46, Issue:14 | A convergent approach to cryptophycin 52 analogues: synthesis and biological evaluation of a novel series of fragment a epoxides and chlorohydrins. |
| AID111307 | In vivo antitumor activity against murine pancreatic adenocarcinoma and measured as number of deaths on a schedule of 5-10 day and at a total dose of 270 mg/kg | 2003 | Journal of medicinal chemistry, Jul-03, Volume: 46, Issue:14 | A convergent approach to cryptophycin 52 analogues: synthesis and biological evaluation of a novel series of fragment a epoxides and chlorohydrins. |
| AID43714 | In vitro cytotoxicity against human leukemia CCRF-CEM cell line | 1999 | Bioorganic & medicinal chemistry letters, Feb-08, Volume: 9, Issue:3 | Synthesis and biological evaluation of cryptophycin analogs with substitution at C-6 (fragment C region). |
| AID120741 | Ratio of the median tumor weight in the treatment group over the median tumor weight in the control group on a schedule of 5-10 day and at a total dose of 402 mg/kg | 2003 | Journal of medicinal chemistry, Jul-03, Volume: 46, Issue:14 | A convergent approach to cryptophycin 52 analogues: synthesis and biological evaluation of a novel series of fragment a epoxides and chlorohydrins. |
| AID111306 | In vivo antitumor activity against murine pancreatic adenocarcinoma and measured as number of deaths on a schedule of 5-10 day and at a total dose of 210 mg/kg | 2003 | Journal of medicinal chemistry, Jul-03, Volume: 46, Issue:14 | A convergent approach to cryptophycin 52 analogues: synthesis and biological evaluation of a novel series of fragment a epoxides and chlorohydrins. |
| AID115260 | Log cell kill of tumor bearing mice on a schedule of 5-10 day and at a total dose of 402 mg/kg | 2003 | Journal of medicinal chemistry, Jul-03, Volume: 46, Issue:14 | A convergent approach to cryptophycin 52 analogues: synthesis and biological evaluation of a novel series of fragment a epoxides and chlorohydrins. |
| AID120740 | Ratio of the median tumor weight in the treatment group over the median tumor weight in the control group on a schedule of 5-10 day and at a total dose of 270 mg/kg | 2003 | Journal of medicinal chemistry, Jul-03, Volume: 46, Issue:14 | A convergent approach to cryptophycin 52 analogues: synthesis and biological evaluation of a novel series of fragment a epoxides and chlorohydrins. |
| AID124911 | In vivo antitumor activity against murine pancreatic adenocarcinoma and measured as % weight loss on a schedule of 5-10 day and at a total dose of 402 mg/kg | 2003 | Journal of medicinal chemistry, Jul-03, Volume: 46, Issue:14 | A convergent approach to cryptophycin 52 analogues: synthesis and biological evaluation of a novel series of fragment a epoxides and chlorohydrins. |
| AID44346 | In vitro growth inhibitory activity in the human CCRF-CEM leukemia cell line. | 2003 | Journal of medicinal chemistry, Jul-03, Volume: 46, Issue:14 | A convergent approach to cryptophycin 52 analogues: synthesis and biological evaluation of a novel series of fragment a epoxides and chlorohydrins. |
| AID115258 | Log cell kill of tumor bearing mice on a schedule of 5-10 day and at a total dose of 210 mg/kg | 2003 | Journal of medicinal chemistry, Jul-03, Volume: 46, Issue:14 | A convergent approach to cryptophycin 52 analogues: synthesis and biological evaluation of a novel series of fragment a epoxides and chlorohydrins. |
| AID120739 | Ratio of the median tumor weight in the treatment group over the median tumor weight in the control group on a schedule of 5-10 day and at a total dose of 210 mg/kg | 2003 | Journal of medicinal chemistry, Jul-03, Volume: 46, Issue:14 | A convergent approach to cryptophycin 52 analogues: synthesis and biological evaluation of a novel series of fragment a epoxides and chlorohydrins. |
| AID115259 | Log cell kill of tumor bearing mice on a schedule of 5-10 day and at a total dose of 270 mg/kg | 2003 | Journal of medicinal chemistry, Jul-03, Volume: 46, Issue:14 | A convergent approach to cryptophycin 52 analogues: synthesis and biological evaluation of a novel series of fragment a epoxides and chlorohydrins. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (6)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 4 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 12.34
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.34) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (14.29%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (85.71%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||