Page last updated: 2024-11-11

cryptophycin 55

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

cryptophycin 55: chlorohydrin prodrug to cryptophycin 52 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID9896488
CHEMBL ID263425
SCHEMBL ID12092055
MeSH IDM0369977

Synonyms (7)

Synonym
CHEMBL263425
SCHEMBL12092055
cryptophycin 55
(3s,10r,13e,16s)-16-[(2r,3r,4s)-4-chloro-3-hydroxy-4-phenylbutan-2-yl]-10-[(3-chloro-4-methoxyphenyl)methyl]-6,6-dimethyl-3-(2-methylpropyl)-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone
MXZDFWPOJAPNJL-VIVUCZJBSA-N
186256-69-9
DTXSID501046680

Research Excerpts

Pharmacokinetics

ExcerptReferenceRelevance
" Pharmacokinetic parameters were computed using noncompartmental methods."( Pharmacokinetics and tissue distribution of cryptophycin 52 (C-52) epoxide and cryptophycin 55 (C-55) chlorohydrin in mice with subcutaneous tumors.
Boinpally, RR; Corbett, TH; Horwitz, JP; Jasti, BR; Kushner, J; Parchment, RE; Polin, L; White, K; Wiegand, RA; Zhou, SL, 2003
)
0.55
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (14)

Assay IDTitleYearJournalArticle
AID111308In vivo antitumor activity against murine pancreatic adenocarcinoma and measured as number of deaths on a schedule of 5-10 day and at a total dose of 402 mg/kg2003Journal of medicinal chemistry, Jul-03, Volume: 46, Issue:14
A convergent approach to cryptophycin 52 analogues: synthesis and biological evaluation of a novel series of fragment a epoxides and chlorohydrins.
AID124783In vivo antitumor activity against murine pancreatic adenocarcinoma and measured as % weight loss on a schedule of 5-10 day and at a total dose of 210 mg/kg2003Journal of medicinal chemistry, Jul-03, Volume: 46, Issue:14
A convergent approach to cryptophycin 52 analogues: synthesis and biological evaluation of a novel series of fragment a epoxides and chlorohydrins.
AID124784In vivo antitumor activity against murine pancreatic adenocarcinoma and measured as % weight loss on a schedule of 5-10 day and at a total dose of 270 mg/kg2003Journal of medicinal chemistry, Jul-03, Volume: 46, Issue:14
A convergent approach to cryptophycin 52 analogues: synthesis and biological evaluation of a novel series of fragment a epoxides and chlorohydrins.
AID111307In vivo antitumor activity against murine pancreatic adenocarcinoma and measured as number of deaths on a schedule of 5-10 day and at a total dose of 270 mg/kg2003Journal of medicinal chemistry, Jul-03, Volume: 46, Issue:14
A convergent approach to cryptophycin 52 analogues: synthesis and biological evaluation of a novel series of fragment a epoxides and chlorohydrins.
AID43714In vitro cytotoxicity against human leukemia CCRF-CEM cell line1999Bioorganic & medicinal chemistry letters, Feb-08, Volume: 9, Issue:3
Synthesis and biological evaluation of cryptophycin analogs with substitution at C-6 (fragment C region).
AID120741Ratio of the median tumor weight in the treatment group over the median tumor weight in the control group on a schedule of 5-10 day and at a total dose of 402 mg/kg2003Journal of medicinal chemistry, Jul-03, Volume: 46, Issue:14
A convergent approach to cryptophycin 52 analogues: synthesis and biological evaluation of a novel series of fragment a epoxides and chlorohydrins.
AID111306In vivo antitumor activity against murine pancreatic adenocarcinoma and measured as number of deaths on a schedule of 5-10 day and at a total dose of 210 mg/kg2003Journal of medicinal chemistry, Jul-03, Volume: 46, Issue:14
A convergent approach to cryptophycin 52 analogues: synthesis and biological evaluation of a novel series of fragment a epoxides and chlorohydrins.
AID115260Log cell kill of tumor bearing mice on a schedule of 5-10 day and at a total dose of 402 mg/kg2003Journal of medicinal chemistry, Jul-03, Volume: 46, Issue:14
A convergent approach to cryptophycin 52 analogues: synthesis and biological evaluation of a novel series of fragment a epoxides and chlorohydrins.
AID120740Ratio of the median tumor weight in the treatment group over the median tumor weight in the control group on a schedule of 5-10 day and at a total dose of 270 mg/kg2003Journal of medicinal chemistry, Jul-03, Volume: 46, Issue:14
A convergent approach to cryptophycin 52 analogues: synthesis and biological evaluation of a novel series of fragment a epoxides and chlorohydrins.
AID124911In vivo antitumor activity against murine pancreatic adenocarcinoma and measured as % weight loss on a schedule of 5-10 day and at a total dose of 402 mg/kg2003Journal of medicinal chemistry, Jul-03, Volume: 46, Issue:14
A convergent approach to cryptophycin 52 analogues: synthesis and biological evaluation of a novel series of fragment a epoxides and chlorohydrins.
AID44346In vitro growth inhibitory activity in the human CCRF-CEM leukemia cell line.2003Journal of medicinal chemistry, Jul-03, Volume: 46, Issue:14
A convergent approach to cryptophycin 52 analogues: synthesis and biological evaluation of a novel series of fragment a epoxides and chlorohydrins.
AID115258Log cell kill of tumor bearing mice on a schedule of 5-10 day and at a total dose of 210 mg/kg2003Journal of medicinal chemistry, Jul-03, Volume: 46, Issue:14
A convergent approach to cryptophycin 52 analogues: synthesis and biological evaluation of a novel series of fragment a epoxides and chlorohydrins.
AID120739Ratio of the median tumor weight in the treatment group over the median tumor weight in the control group on a schedule of 5-10 day and at a total dose of 210 mg/kg2003Journal of medicinal chemistry, Jul-03, Volume: 46, Issue:14
A convergent approach to cryptophycin 52 analogues: synthesis and biological evaluation of a novel series of fragment a epoxides and chlorohydrins.
AID115259Log cell kill of tumor bearing mice on a schedule of 5-10 day and at a total dose of 270 mg/kg2003Journal of medicinal chemistry, Jul-03, Volume: 46, Issue:14
A convergent approach to cryptophycin 52 analogues: synthesis and biological evaluation of a novel series of fragment a epoxides and chlorohydrins.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (16.67)18.2507
2000's4 (66.67)29.6817
2010's0 (0.00)24.3611
2020's1 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.34

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.34 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.42 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.34)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (14.29%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (85.71%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]