Compounds > bietaserpine
Page last updated: 2024-11-08

bietaserpine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

bietaserpine: hypotensive agent; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID20054848
CHEMBL ID3989595
CHEBI ID125518
SCHEMBL ID309277
MeSH IDM0045635

Synonyms (44)

Synonym
D07167
bietaserpine (prop.inn)
nsc-369865
53-18-9
bietaserpina [inn-spanish]
bietaserpine
methyl 13-(2-(diethylamino)ethyl)-1,2,3,4,4aalpha,5,7,8,13,13bbeta,14,14aalpha-dodecahydro-2alpha,11-dimethoxy-3beta-((3,4,5-trimethoxybenzoyl)oxy)benz(g)indolo(2,3-a)quinolizine-1beta-carboxylate
1-(2-(diethylamino)ethyl)reserpine
s 1210
methyl 1-(2-(diethylamino)ethyl)-18beta-hydroxy-11,17alpha-dimethoxy-3beta,20alpha-yohimban-16beta-carboxylate, 3,4,5-trimethoxybenzoate (ester)
methyl 13-(2-diethylaminoethyl)-2,11-dimethoxy-3-(3,4,5-trimethoxybenzoyloxy)yohimban-1-carboxylic acid
3-beta,20-alpha-yohimban-16-beta-carboxylic acid, 1-(2-(diethylamino)ethyl)-18-beta-hydroxy-11,17-alpha-dimethoxy-, methyl ester, 3,4,5-trimethoxybenzoate (ester)
einecs 200-165-0
bietaserpinum [inn-latin]
methyl 1alpha,2beta,3alpha,4,4aalpha,5,7,8,13,13bbeta,14,14aalpha-dodecahydro-1-(2-diethylaminoethyl)-2,11-dimethoxy-3beta-(3,4,5-trimethoxybenzoyloxy)-benz(g)indole-(2,3-a)quinolizine-1beta-carboxylate
n-diaethylaminoaethyl-reserpin [german]
l 652
reserpine, 1-(2-(diethylamino)ethyl)-
dl 152
nsc 369865
bietaserpine [inn:dcf]
(1r,15s,17r,18r,19s,20s)-3-[2-(diethylamino)ethyl]-6,18-dimethoxy-17-[oxo-(3,4,5-trimethoxyphenyl)methoxy]-11,12,14,15,16,17,18,19,20,21-decahydro-1h-yohimban-19-carboxylic acid methyl ester
CHEBI:125518
0p5b94fvd5 ,
n-diaethylaminoaethyl-reserpin
unii-0p5b94fvd5
bietaserpina
s-1210 ,
bietaserpinum
BRD-K25210139-001-01-3
SCHEMBL309277
bietaserpine [mi]
methyl 13-(2-(diethylamino)ethyl)-1,2,3,4,4a.alpha.,5,7,8,13,13b.beta.,14,14a.alpha.-dodecahydro-2.alpha.,11-dimethoxy-3.beta.-((3,4,5-trimethoxybenzoyl)oxy)benz(g)indolo(2,3-a)quinolizine-1.beta.-carboxylate
bietaserpine [who-dd]
bietaserpine [mart.]
bietaserpine [inn]
methyl 1-[2-(diethylamino)ethyl]-18beta-hydroxy-11,17alpha-dimethoxy-3beta,20alpha-yohimban-16beta-carboxylate, 3,4,5-trimethoxybenzoate (ester)
dl-152 free base
Q4904688
DB13575
CHEMBL3989595
DTXSID301018918
methyl (1r,15s,17r,18r,19s,20s)-3-[2-(diethylamino)ethyl]-6,18-dimethoxy-17-(3,4,5-trimethoxybenzoyl)oxy-11,12,14,15,16,17,18,19,20,21-decahydro-1h-yohimban-19-carboxylate
AKOS040750798

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" DL-152 was found to be toxic to cells of all the tumor models tested (KHT fibrosarcoma, RIF-1 fibrosarcoma, EMT-6 adenocarcinoma and Lewis lung carcinoma) when the drug was given by intraperitoneal injection to the tumor-bearing mouse and cell survival was measured by excision assay."( Factors influencing the toxicity of diethylaminoethylreserpine to tumor cells: studies with four transplantable tumors.
Lehnert, S, 1987)		0.27
" Hypoxic cells were detectable in 10-day-old lung tumors, a time at which the tumors were still resistant to the toxic effects of DL-152."( Toxicity of diethylaminoreserpine to a transplantable tumor: the significance of the presence of hypoxic cells.
Lehnert, S, 1982)		0.26
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
yohimban alkaloid
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19906 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
reserpine
Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.. reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.		8.2160alkaloid ester;
methyl ester;
yohimban alkaloid		adrenergic uptake inhibitor;
antihypertensive agent;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
environmental contaminant;
first generation antipsychotic;
plant metabolite;
xenobiotic
ConditionIndicatedRelationship StrengthStudiesTrials
Blood Pressure, Low
[description not available]		01.9410
Hypotension
Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.		01.9410
Fibrosarcoma
A sarcoma derived from deep fibrous tissue, characterized by bundles of immature proliferating fibroblasts with variable collagen formation, which tends to invade locally and metastasize by the bloodstream. (Stedman, 25th ed)		02.8840
EHS Tumor
[description not available]		02.6530
Adenocarcinoma, Basal Cell
[description not available]		02.3720
Experimental Mammary Neoplasms
[description not available]		01.9610
Adenocarcinoma
A malignant epithelial tumor with a glandular organization.		02.3720
Carcinoma, Anaplastic
[description not available]		01.9710
Cancer of Lung
[description not available]		01.9710
Carcinoma
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.		01.9710
Lung Neoplasms
Tumors or cancer of the LUNG.		01.9710