ambuic-acid and Gram-Positive-Bacterial-Infections

ambuic-acid has been researched along with Gram-Positive-Bacterial-Infections* in 1 studies

Other Studies

1 other study(ies) available for ambuic-acid and Gram-Positive-Bacterial-Infections

Article	Year
Signal Biosynthesis Inhibition with Ambuic Acid as a Strategy To Target Antibiotic-Resistant Infections. Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:8 There has been major interest by the scientific community in antivirulence approaches against bacterial infections. However, partly due to a lack of viable lead compounds, antivirulence therapeutics have yet to reach the clinic. Here we investigate the development of an antivirulence lead targeting quorum sensing signal biosynthesis, a process that is conserved in Gram-positive bacterial pathogens. Some preliminary studies suggest that the small molecule ambuic acid is a signal biosynthesis inhibitor. To confirm this, we constructed a methicillin-resistant Topics: Animals; Anti-Bacterial Agents; Bacterial Proteins; Cyclohexanones; Disease Models, Animal; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Male; Methicillin-Resistant Staphylococcus aureus; Mice; Mice, Inbred BALB C; Peptides, Cyclic; Quorum Sensing; Signal Transduction; Staphylococcal Infections; Virulence Factors	2017

Article

Year

Signal Biosynthesis Inhibition with Ambuic Acid as a Strategy To Target Antibiotic-Resistant Infections.

Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:8

There has been major interest by the scientific community in antivirulence approaches against bacterial infections. However, partly due to a lack of viable lead compounds, antivirulence therapeutics have yet to reach the clinic. Here we investigate the development of an antivirulence lead targeting quorum sensing signal biosynthesis, a process that is conserved in Gram-positive bacterial pathogens. Some preliminary studies suggest that the small molecule ambuic acid is a signal biosynthesis inhibitor. To confirm this, we constructed a methicillin-resistant

Topics: Animals; Anti-Bacterial Agents; Bacterial Proteins; Cyclohexanones; Disease Models, Animal; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Male; Methicillin-Resistant Staphylococcus aureus; Mice; Mice, Inbred BALB C; Peptides, Cyclic; Quorum Sensing; Signal Transduction; Staphylococcal Infections; Virulence Factors

2017