| Assay ID | Title | Year | Journal | Article |
|---|
| AID1655599 | Inhibition of GLI1 transcriptional activity in human A375 cells assessed as downregulation of GLI2 mRNA expression at 5 uM incubated for 48 hrs by qPCR analysis | 2020 | ACS medicinal chemistry letters, May-14, Volume: 11, Issue:5
| Pharmacophore-Based Virtual Screening for Identification of Negative Modulators of GLI1 as Potential Anticancer Agents. |
| AID1655600 | Inhibition of GLI1 transcriptional activity in human A375 cells assessed as downregulation of Cyclin D1 mRNA expression at 5 uM incubated for 48 hrs by qPCR analysis | 2020 | ACS medicinal chemistry letters, May-14, Volume: 11, Issue:5
| Pharmacophore-Based Virtual Screening for Identification of Negative Modulators of GLI1 as Potential Anticancer Agents. |
| AID1655593 | Antiproliferative activity against human DaOY cells assessed as reduction in cell viability incubated for 72 hrs by trypan blue or crystal violet staining based assay | 2020 | ACS medicinal chemistry letters, May-14, Volume: 11, Issue:5
| Pharmacophore-Based Virtual Screening for Identification of Negative Modulators of GLI1 as Potential Anticancer Agents. |
| AID1655598 | Inhibition of GLI1 transcriptional activity in human A375 cells assessed as downregulation of HIP1 mRNA expression at 5 uM incubated for 48 hrs by qPCR analysis | 2020 | ACS medicinal chemistry letters, May-14, Volume: 11, Issue:5
| Pharmacophore-Based Virtual Screening for Identification of Negative Modulators of GLI1 as Potential Anticancer Agents. |
| AID1655595 | Inhibition of GLI1 transcriptional activity in HH-responsive mouse NIH3T3 cells assessed as reduction in SAG-induced luciferase activity at 5 uM incubated for 48 hrs by luciferase reporter gene assay relative to control | 2020 | ACS medicinal chemistry letters, May-14, Volume: 11, Issue:5
| Pharmacophore-Based Virtual Screening for Identification of Negative Modulators of GLI1 as Potential Anticancer Agents. |
| AID1406172 | Growth inhibition of mouse Ptch+/- medulloblastoma cells at 0.5 uM after 72 hrs relative to control | 2018 | European journal of medicinal chemistry, Aug-05, Volume: 156 | Synergistic inhibition of the Hedgehog pathway by newly designed Smo and Gli antagonists bearing the isoflavone scaffold. |
| AID1655597 | Inhibition of GLI1 transcriptional activity in human A375 cells assessed as downregulation of PTCH1 mRNA expression at 5 uM incubated for 48 hrs by qPCR analysis | 2020 | ACS medicinal chemistry letters, May-14, Volume: 11, Issue:5
| Pharmacophore-Based Virtual Screening for Identification of Negative Modulators of GLI1 as Potential Anticancer Agents. |
| AID1655601 | Antiproliferative activity against human A375 cells transfected with lentivrus-encoding shRNA against GLI1 assessed as reduction in cell viability incubated for 72 hrs by trypan blue or crystal violet staining based assay | 2020 | ACS medicinal chemistry letters, May-14, Volume: 11, Issue:5
| Pharmacophore-Based Virtual Screening for Identification of Negative Modulators of GLI1 as Potential Anticancer Agents. |
| AID1655596 | Inhibition of GLI1 transcriptional activity in human A375 cells assessed as downregulation of GLI1 mRNA expression at 5 uM incubated for 48 hrs by qPCR analysis | 2020 | ACS medicinal chemistry letters, May-14, Volume: 11, Issue:5
| Pharmacophore-Based Virtual Screening for Identification of Negative Modulators of GLI1 as Potential Anticancer Agents. |
| AID1655603 | Antiproliferative activity against human A375 cells transfected with lentivrus-encoding shRNA against GLI2 assessed as reduction in cell viability incubated for 72 hrs by trypan blue or crystal violet staining based assay | 2020 | ACS medicinal chemistry letters, May-14, Volume: 11, Issue:5
| Pharmacophore-Based Virtual Screening for Identification of Negative Modulators of GLI1 as Potential Anticancer Agents. |
| AID1655594 | Inhibition of GLI1 transcriptional activity in HH-responsive mouse NIH3T3 cells assessed as reduction in GLI1 protein expression at 5 uM incubated for 48 hrs in presence of SAG by Western blot analysis | 2020 | ACS medicinal chemistry letters, May-14, Volume: 11, Issue:5
| Pharmacophore-Based Virtual Screening for Identification of Negative Modulators of GLI1 as Potential Anticancer Agents. |
| AID1655592 | Antiproliferative activity against human A375 cells assessed as reduction in cell viability incubated for 72 hrs by trypan blue or crystal violet staining based assay | 2020 | ACS medicinal chemistry letters, May-14, Volume: 11, Issue:5
| Pharmacophore-Based Virtual Screening for Identification of Negative Modulators of GLI1 as Potential Anticancer Agents. |
| AID1406174 | Growth inhibition of mouse Ptch+/- medulloblastoma cells at 2 uM after 72 hrs relative to control | 2018 | European journal of medicinal chemistry, Aug-05, Volume: 156 | Synergistic inhibition of the Hedgehog pathway by newly designed Smo and Gli antagonists bearing the isoflavone scaffold. |
| AID1406173 | Growth inhibition of mouse Ptch+/- medulloblastoma cells at 1 uM after 72 hrs relative to control | 2018 | European journal of medicinal chemistry, Aug-05, Volume: 156 | Synergistic inhibition of the Hedgehog pathway by newly designed Smo and Gli antagonists bearing the isoflavone scaffold. |
| AID1406171 | Growth inhibition of mouse Ptch+/- medulloblastoma cells at 0.25 uM after 72 hrs relative to control | 2018 | European journal of medicinal chemistry, Aug-05, Volume: 156 | Synergistic inhibition of the Hedgehog pathway by newly designed Smo and Gli antagonists bearing the isoflavone scaffold. |
| AID1406170 | Growth inhibition of mouse Ptch+/- medulloblastoma cells at 0.125 uM after 72 hrs relative to control | 2018 | European journal of medicinal chemistry, Aug-05, Volume: 156 | Synergistic inhibition of the Hedgehog pathway by newly designed Smo and Gli antagonists bearing the isoflavone scaffold. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |