Compounds > 2-ketopentanoic acid
Page last updated: 2024-11-06

2-ketopentanoic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2-ketopentanoic acid: RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

2-oxopentanoic acid : An oxopentanoic acid carrying an oxo group at position 2. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID74563
CHEMBL ID1162544
CHEBI ID33033
SCHEMBL ID24359
MeSH IDM0065634

Synonyms (59)

Synonym
LS-13052
2-oxovaleric acid
CHEBI:33033 ,
2-ketopentanoic acid
alpha-keto-n-valeric acid
inchi=1/c5h8o3/c1-2-3-4(6)5(7)8/h2-3h2,1h3,(h,7,8
1821-02-9
2-oxopentanoic acid
alpha-ketovaleric acid
C06255
LMFA01060004
2-oxo-pentanoic acid
2-keto valeric acid
2-oxovaleric acid, >=98.0% (t)
valeric acid, 2-oxo-
81A83193-25AB-43C8-AE12-CF7739DB0AE5
2-ketovaleric acid
K0015
CHEMBL1162544
NCGC00248680-01
cas-1821-02-9
dtxcid301647
tox21_200532
NCGC00258086-01
dtxsid3021647 ,
pentanoic acid, 2-oxo-
alpha-oxopentanoic acid
AKOS006222788
01i0oe93a7 ,
unii-01i0oe93a7
einecs 217-340-2
2-oxo-n-valeric acid
SCHEMBL24359
2-oxopentanoic acid #
.alpha.-keto-n-valeric acid
2-keto-n-valeric acid
69o ,
pentanoic acid, oxo-
mfcd00066435
a-oxopentanoic acid
alpha-oxo-n-valeric acid
a-oxopentanoate
alpha-oxovaleric acid
2-oxo-pentanoate
a-oxovaleric acid
alpha-oxopentanoate
alpha-keto-valeric acid
a-keto-valeric acid
2-oxo-valeric acid
J-011655
CS-0059565
HY-113098
Q4734905
a-oxo-n-valeric acid
2-oxopentanoic'acid
AMY6081
T71973
PD102018
SY052445
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
human metaboliteAny mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
oxopentanoic acidA C5 fatty acid carrying an oxo group at any position.
2-oxo monocarboxylic acidAny monocarboxylic acid having a 2-oxo substituent.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (4)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency24.33650.001022.650876.6163AID1224893
estrogen nuclear receptor alphaHomo sapiens (human)Potency12.30280.000229.305416,493.5996AID743075
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency24.33650.000627.21521,122.0200AID743219
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (4)

Processvia Protein(s)Taxonomy
diaminopimelate biosynthetic process4-hydroxy-tetrahydrodipicolinate synthaseEscherichia coli K-12
lysine biosynthetic process4-hydroxy-tetrahydrodipicolinate synthaseEscherichia coli K-12
lysine biosynthetic process via diaminopimelate4-hydroxy-tetrahydrodipicolinate synthaseEscherichia coli K-12
diaminopimelate biosynthetic process4-hydroxy-tetrahydrodipicolinate synthaseEscherichia coli K-12
small molecule metabolic process4-hydroxy-tetrahydrodipicolinate synthaseEscherichia coli K-12
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (3)

Processvia Protein(s)Taxonomy
4-hydroxy-tetrahydrodipicolinate synthase activity4-hydroxy-tetrahydrodipicolinate synthaseEscherichia coli K-12
lyase activity4-hydroxy-tetrahydrodipicolinate synthaseEscherichia coli K-12
identical protein binding4-hydroxy-tetrahydrodipicolinate synthaseEscherichia coli K-12
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (2)

Processvia Protein(s)Taxonomy
cytoplasm4-hydroxy-tetrahydrodipicolinate synthaseEscherichia coli K-12
cytosol4-hydroxy-tetrahydrodipicolinate synthaseEscherichia coli K-12
cytosol4-hydroxy-tetrahydrodipicolinate synthaseEscherichia coli K-12
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID388791Inhibition of Escherichia coli DHDPS2008Bioorganic & medicinal chemistry, Dec-01, Volume: 16, Issue:23
Irreversible inhibition of dihydrodipicolinate synthase by 4-oxo-heptenedioic acid analogues.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (20.00)18.7374
1990's2 (20.00)18.2507
2000's4 (40.00)29.6817
2010's2 (20.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.02

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.02 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.02)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (10.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (90.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
alpha-ketoisovalerate
alpha-ketoisovalerate: RN given refers to parent cpd. 3-methyl-2-oxobutanoate : A 2-oxo monocarboxylic acid anion that is the conjugate base of 3-methyl-2-oxobutanoic acid, arising from deprotonation of the carboxy group.. 3-methyl-2-oxobutanoic acid : A 2-oxo monocarboxylic acid that is the 2-oxo derivative of isovaleric acid.		1.98102-oxo monocarboxylic acid;
branched-chain keto acid		human metabolite;
Saccharomyces cerevisiae metabolite
alpha-ketobutyric acid
alpha-ketobutyric acid: RN given refers to parent cpd; structure. 2-oxobutanoic acid : A 2-oxo monocarboxylic acid that is the 2-oxo derivative of butanoic acid.		2.67302-oxo monocarboxylic acid;
short-chain fatty acid
2-keto-4-methylvalerate
alpha-ketoisocaproic acid: RN given refers to parent cpd. 4-methyl-2-oxopentanoate : A 2-oxo monocarboxylic acid anion that is the conjugate base of 4-methyl-2-oxopentanoic acid.. 4-methyl-2-oxopentanoic acid : A 2-oxo monocarboxylic acid that is pentanoic acid (valeric acid) substituted with a keto group at C-2 and a methyl group at C-4. A metabolite that has been found to accumulate in maple syrup urine disease.		1.99102-oxo monocarboxylic acid;
branched-chain keto acid		algal metabolite;
human metabolite
glyoxylic acid
glyoxylic acid: RN given refers to parent cpd. glyoxylic acid : A 2-oxo monocarboxylic acid that is acetic acid bearing an oxo group at the alpha carbon atom.		2.04102-oxo monocarboxylic acid;
aldehydic acid		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
hydroxypyruvic acid
hydroxypyruvic acid: RN given refers to parent cpd. 3-hydroxypyruvic acid : A 2-oxo monocarboxylic acid that is pyruvic acid in which one of the methyl hydrogens is substituted by a hydroxy group. It is an intermediate involved in the glycine and serine metabolism.		1.98102-oxo monocarboxylic acid;
3-hydroxy monocarboxylic acid;
primary alpha-hydroxy ketone		Escherichia coli metabolite;
human metabolite
phenylpyruvic acid
phenylpyruvic acid: RN given refers to parent cpd. phenylpyruvate : A 2-oxo monocarboxylic acid anion resulting from deprotonation of the carboxy group of either keto- or enol-phenylpyruvic acid.. keto-phenylpyruvic acid : A 2-oxo monocarboxylic acid that is 3-phenylpropanoic acid substituted by an oxo group at position 2. It is an intermediate metabolite in the phenylalanine pathway.		1.98102-oxo monocarboxylic acidchromogenic compound;
EC 6.4.1.1 (pyruvate carboxylase) inhibitor;
fundamental metabolite
pyruvic acid
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed). pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.		1.96102-oxo monocarboxylic acidcofactor;
fundamental metabolite
threonine
Threonine: An essential amino acid occurring naturally in the L-form, which is the active form. It is found in eggs, milk, gelatin, and other proteins.. threonine : An alpha-amino acid in which one of the hydrogens attached to the alpha-carbon of glycine is substituted by a 1-hydroxyethyl group.		1.9810amino acid zwitterion;
aspartate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid;
threonine		algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
sodium azide
Sodium Azide: A cytochrome oxidase inhibitor which is a nitridizing agent and an inhibitor of terminal oxidation. (From Merck Index, 12th ed). sodium azide : The sodium salt of hydrogen azide (hydrazoic acid).		1.9910inorganic sodium saltantibacterial agent;
explosive;
mitochondrial respiratory-chain inhibitor;
mutagen
3-fluoropyruvate
3-fluoropyruvate: a substrate for E coli pyruvate dehydrogenase; structure; RN given refers to parent cpd. 3-fluoropyruvic acid : A pyruvic acid derivative having a 3-fluoro substituent.. 3-fluoropyruvate : The anion of 3-fluoropyruvic acid.		2.04102-oxo monocarboxylic acid;
organofluorine compound
valerates
Valerates: Derivatives of valeric acid, including its salts and esters.		210short-chain fatty acid anion;
straight-chain saturated fatty acid anion		plant metabolite
pantoic acid
pantoic acid: RN given refers to cpd without isomeric designation		2.0710pantoic acid
lacticin 481
lacticin 481: amino acid sequence given in first source; a lantibiotic; GenBank X71410 (L. lactis)		2.0110
ConditionIndicatedRelationship StrengthStudiesTrials
Adenohypophyseal Hyposecretion
[description not available]		03.411
Hypopituitarism
Diminution or cessation of secretion of one or more hormones from the anterior pituitary gland (including LH; FOLLICLE STIMULATING HORMONE; SOMATOTROPIN; and CORTICOTROPIN). This may result from surgical or radiation ablation, non-secretory PITUITARY NEOPLASMS, metastatic tumors, infarction, PITUITARY APOPLEXY, infiltrative or granulomatous processes, and other conditions.		03.411