Compounds > albonoursin
Page last updated: 2024-12-11

albonoursin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

albonoursin: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

albonoursin : A member of the class of 2,5-diketopiperazines that is piperazine-2,5-dione in which the two hydrogen at position 3 and those at position 6 are replaced by benzylidene and isobutylidene groups (the 3Z,6Z-geoisomer). [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID6109346
CHEMBL ID455787
CHEBI ID71609
SCHEMBL ID13360291
MeSH IDM0049026

Synonyms (23)

Synonym
2,5-piperazinedione, 3-benzylidene-6-isobutylidene-
3-benzylidene-6-isobutylidene-2,5-dioxopiperazine
b-73
albonoursin
2,5-piperazinedione, 3-(2-methylpropylidene)-6-(phenylmethylene)-, (z,z)-
albonursin
p-42-2
albonoursine
c15h16n2o2
chebi:71609 ,
CHEMBL455787
(3z,6z)-3-benzylidene-6-(2-methylpropylidene)piperazine-2,5-dione
1222-90-8
C20520
cyclo(deltaleu-deltaphe)
cyclo(dehydroleucyl-dehydrophenylalanyl)
cyclo(dehydrophenylalanyl-dehydroleucyl)
cyclo(deltaphe-deltaleu)
SCHEMBL13360291
Q27139752
(3e,6e)-3-benzylidene-6-(2-methylpropylidene)piperazine-2,5-dione
DTXSID801318208
AKOS040746523

Research Excerpts

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
2,5-diketopiperazinesAny piperazinone that has a piperazine-2,5-dione skeleton.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID334550Cytotoxicity against human SH-SY5Y cells overexpressing dominant negative mutant of p53 upto 100 uM2002Journal of natural products, May, Volume: 65, Issue:5
Isolation of streptonigrin and its novel derivative from Micromonospora as inducing agents of p53-dependent cell apoptosis.
AID334549Cytotoxicity against human wild type SH-SY5Y cells upto 100 uM2002Journal of natural products, May, Volume: 65, Issue:5
Isolation of streptonigrin and its novel derivative from Micromonospora as inducing agents of p53-dependent cell apoptosis.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (16.67)18.2507
2000's5 (83.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 20.04

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index20.04 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.36 (4.65)
Search Engine Demand Index15.26 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (20.04)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
streptonigrin
[no description available]		2.0110pyridines;
quinolone		antimicrobial agent;
antineoplastic agent
cyclo(leucyl-phenylalanyl)
cyclo(leucyl-phenylalanyl): has pronuclear fusion inhibitory activity; isolated from Streptomyces albulus; structure in first source. cyclo(L-phenylalanyl-L-leucyl) : A member of the class of 2,5-diketopiperazines that is piperazine-2,5-dione in which one hydrogen at position 3 and one hydrogen at position 6 are replaced by benzyl and isobutyl groups (the 3S,6S-diastereomer).		2102,5-diketopiperazinesmetabolite
phenylahistin
phenylahistin: antineoplastic from Aspergillus ustus; structure in first source		2.0110
ConditionIndicatedRelationship StrengthStudiesTrials
Neuroblastoma
A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)		02.0110