8-hydroxy-2'-deoxyguanosine DNA binding

Definition

Target type: molecularfunction

Binding to 8-hydroxy-2'-deoxyguanosine an oxidized purine residue found in damaged DNA. [GO_REF:0000067, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:19734539]

8-hydroxy-2'-deoxyguanosine (8-oxo-dG) is a highly mutagenic DNA lesion that arises from the oxidation of guanine. This lesion is formed by reactive oxygen species, such as hydroxyl radicals, and can lead to mutations in DNA if not repaired. The DNA binding function of 8-oxo-dG is a critical part of the cellular response to oxidative stress. 8-oxo-dG binds to specific DNA repair enzymes, including OGG1, which recognizes and removes the lesion from DNA. This recognition and removal process is crucial for maintaining the integrity of the genome and preventing the accumulation of mutations that can lead to cancer and other diseases. Additionally, 8-oxo-dG can also bind to other DNA-binding proteins, such as transcription factors and polymerases, which can interfere with their normal functions. These interactions can alter gene expression and contribute to the cellular response to oxidative stress.'
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Proteins (3)

Compounds (3)