Protection of telomeres protein 1

A protection of telomeres protein 1 that is encoded in the genome of human. [PRO:CNx, Reactome:R-HSA-174890]

Synonyms

hPot1;
POT1-like telomere end-binding protein

Research

Bioassay Publications (1)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (100.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (1)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
braco-19	Homo sapiens (human)	IC50	63.0000	1	1

Enables

This protein enables 9 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
telomerase inhibitor activity	molecular function	Binds to and stops, prevents or reduces the activity of telomerase. [GOC:dph, GOC:krc, GOC:tb]
DEAD/H-box RNA helicase binding	molecular function	Binding to a DEAD/H-box RNA helicase. [GOC:jl]
telomeric DNA binding	molecular function	Binding to a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end. [GOC:jl, SO:0000624]
single-stranded telomeric DNA binding	molecular function	Binding to single-stranded telomere-associated DNA. [GOC:jl, ISBN:0321000382]
telomeric D-loop binding	molecular function	Binding to a telomeric D-loop. A telomeric D-loop is a three-stranded DNA displacement loop that forms at the site where the telomeric 3' single-stranded DNA overhang (formed of the repeat sequence TTAGGG in mammals) is tucked back inside the double-stranded component of telomeric DNA molecule, thus forming a t-loop or telomeric-loop and protecting the chromosome terminus. [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:19734539]
G-rich strand telomeric DNA binding	molecular function	Binding to G-rich, single-stranded, telomere-associated DNA. [PMID:11349150]
8-hydroxy-2'-deoxyguanosine DNA binding	molecular function	Binding to 8-hydroxy-2'-deoxyguanosine an oxidized purine residue found in damaged DNA. [GO_REF:0000067, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:19734539]
G-rich single-stranded DNA binding	molecular function	Binding to G-rich, single-stranded DNA. [GOC:hjd, PMID:8493094]

Located In

This protein is located in 2 target(s):

Target	Category	Definition
chromosome, telomeric region	cellular component	The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres). [GOC:elh]
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]

Part Of

This protein is part of 2 target(s):

Target	Category	Definition
shelterin complex	cellular component	A nuclear telomere cap complex that is formed by the association of telomeric ssDNA- and dsDNA-binding proteins with telomeric DNA, and is involved in telomere protection and recruitment of telomerase. The complex is known to contain TERF1, TERF2, POT1, RAP1, TINF2 and ACD in mammalian cells, and Pot1, Tpz1, Rap1, Rif1, Rif2 and Taz1 in Saccharomyces. Taz1 and Rap1 (or their mammalian equivalents) form a dsDNA-binding subcomplex, Pot1 and Tpz1 form an ssDNA-binding subcomplex, and the two subcomplexes are bridged by Poz1, which acts as an effector molecule along with Ccq1. [GOC:expert_mf, GOC:mah, GOC:vw, PMID:18828880]
nuclear telomere cap complex	cellular component	A complex of DNA and protein located at the end of a linear chromosome in the nucleus that protects and stabilizes a linear chromosome. [GOC:elh]

Involved In

This protein is involved in 17 target(s):

Target	Category	Definition
telomere maintenance via telomerase	biological process	The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase. [GOC:elh]
telomere capping	biological process	A process in which telomeres are protected from degradation and fusion, thereby ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA. May be mediated by specific single- or double-stranded telomeric DNA binding proteins. [GOC:mah, GOC:rn, PMID:11349150, PMID:11352055]
telomere assembly	biological process	A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a telomere at a non-telomeric double-stranded DNA end. A telomere is a terminal region of a linear chromosome that includes telomeric DNA repeats and associated proteins. [GOC:mah, GOC:ns, PMID:11902675, PMID:8622671]
positive regulation of telomere maintenance	biological process	Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA. [GOC:mah]
regulation of telomere maintenance via telomerase	biological process	Any process that modulates the frequency, rate or extent of the addition of telomeric repeats by telomerase. [GOC:mah]
negative regulation of telomere maintenance via telomerase	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of telomeric repeats by telomerase. [GOC:mah]
positive regulation of telomere maintenance via telomerase	biological process	Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase. [GOC:mah]
DNA duplex unwinding	biological process	The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands. [GOC:isa_complete, GOC:mah]
positive regulation of helicase activity	biological process	Any process that activates or increases the activity of a helicase. [GOC:ai]
positive regulation of telomerase activity	biological process	Any process that activates or increases the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). [GOC:ai]
negative regulation of telomerase activity	biological process	Any process that stops or reduces the activity of the enzyme telomerase, which catalyzes of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). [GOC:ai]
positive regulation of DNA strand elongation	biological process	Any process that increases the rate, frequency or extent of DNA strand elongation. DNA strand elongation is the DNA metabolic process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand. [GOC:mah]
telomeric D-loop disassembly	biological process	A telomere loop disassembly process that results in the disassembly of telomeric D-loops. A telomeric D-loop is a three-stranded DNA displacement loop that forms at the site where the telomeric 3' single-stranded DNA overhang (formed of the repeat sequence TTAGGG in mammals) is tucked back inside the double-stranded component of telomeric DNA molecule, thus forming a t-loop or telomeric-loop and protecting the chromosome terminus. [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:10338204, PMID:24012755]
establishment of protein localization to telomere	biological process	The directed movement of a protein to a specific location in the telomeric region of a chromosome. [GOC:BHF, GOC:mah]
regulation of DNA helicase activity	biological process	Any process that modulates the frequency, rate or extent of ATP-dependent DNA helicase activity. [GOC:rb, GOC:TermGenie, PMID:13679365, PMID:19734539]
positive regulation of DNA helicase activity	biological process	Any process that activates or increases the frequency, rate or extent of ATP-dependent DNA helicase activity. [GOC:rb, GOC:TermGenie, PMID:13679365, PMID:19734539]
regulation of double-strand break repair via nonhomologous end joining	biological process	Any process that modulates the frequency, rate or extent of double-strand break repair via nonhomologous end joining. [GOC:obol]