Page last updated: 2024-10-24

Ac-Asp-Glu binding

Definition

Target type: molecularfunction

Binding to Ac-Asp-Glu. [GO_REF:0000067, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:24863754]

Ac-Asp-Glu binding is a molecular function that describes the interaction between a protein and a specific tripeptide sequence: Acetyl-Aspartic Acid-Glutamic Acid. This tripeptide sequence is often found in the context of larger protein sequences, particularly in the N-terminal regions.

Ac-Asp-Glu binding is frequently associated with:

1. **Protein-Protein Interactions:** The tripeptide motif can act as a recognition site for binding to other proteins. This binding can mediate a variety of cellular processes, including signaling pathways, enzymatic activity regulation, and protein complex assembly.

2. **Enzyme Inhibition:** In some cases, Ac-Asp-Glu binding can inhibit the activity of enzymes. This can occur when the tripeptide sequence binds to the active site of the enzyme, preventing the substrate from binding.

3. **Structural Roles:** Ac-Asp-Glu binding can also contribute to the structural integrity of proteins. The interaction between the tripeptide and other protein domains can help to stabilize the overall protein structure.

The specific biological role of Ac-Asp-Glu binding is often dependent on the context of the interacting proteins and the cellular environment. This molecular function is important for understanding a wide range of biological processes and can serve as a target for drug discovery and development.'
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Proteins (1)

ProteinDefinitionTaxonomy
Glutamate carboxypeptidase 2A glutamate carboxypeptidase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q04609]Homo sapiens (human)

Compounds (13)

CompoundDefinitionClassesRoles
glutamic acidglutamic acid : An alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2.

Glutamic Acid: A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.
glutamic acid;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid
Escherichia coli metabolite;
ferroptosis inducer;
micronutrient;
mouse metabolite;
neurotransmitter;
nutraceutical
quisqualic acidQuisqualic Acid: An agonist at two subsets of excitatory amino acid receptors, ionotropic receptors that directly control membrane channels and metabotropic receptors that indirectly mediate calcium mobilization from intracellular stores. The compound is obtained from the seeds and fruit of Quisqualis chinensis.non-proteinogenic alpha-amino acid
plasmenylserineO-phospho-L-serine : The L-enantiomer of O-phosphoserine.

O-phosphoserine : A serine derivative that is serine substituted at the oxygen atom by a phosphono group.

plasmenylserine: RN given refers to (L)-isomer
O-phosphoserineEC 1.4.7.1 [glutamate synthase (ferredoxin)] inhibitor;
EC 2.5.1.49 (O-acetylhomoserine aminocarboxypropyltransferase) inhibitor;
EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
serine o-sulfateL-serine O-sulfate : A non-proteinogenic L-alpha-amino acid that is the O-sulfo derivative of L-serine.

serine O-sulfate: RN given refers to (L)-isomer
L-serine derivative;
non-proteinogenic L-alpha-amino acid;
O-sulfoamino acid
isospaglumic acidAc-Asp-Glu : A dipeptide composed of N-acetyl-L-aspartic acid and L-glutamic acid joined by a peptide linkage.

isospaglumic acid: mediator in the sensitivity of animals to hyperbaric oxygenation; Naaxia is the tradename; apparently can have both a neuroprotective and a neurotoxic effect
dipeptidehuman metabolite
sq 14,6032-benzyl-3-mercaptopropanoic acid: structure; carboxypeptidase inhibitor
willardiine3-(uracil-1-yl)-L-alanine : The 3-(uracil-1-yl) derivative of L-alanine.

willardiine: isolated from seeds of Acacia willariana; structure
amino acid zwitterion;
L-alanine derivative;
non-proteinogenic L-alpha-amino acid
gamma-glutamyl hydroxamateglutamine hydroxamate : A hydroxamic acid that is L-glutamine hydroxylated at N-5.amino acid zwitterion;
glutamic acid derivative;
hydroxamic acid
phenobarbital sodium2-(phosphonomethyl)pentanedioic acid: an N-acetylated alpha-linked acidic dipeptidase (NAALADase) antagonist
gpi 56932-(3-mercaptopropyl)pentanedioic acid: inhibits glutamate carboxypeptidase II; structure in first source
zj43ZJ43: N-acetylaspartylglutamate (NAAG) peptidase inhibitor; structure in first source
psma-617PSMA-617: inhibits prostate-specific membrane antigen; structure in first source