3-deoxyglucosone dehydrogenase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: 3-deoxyglucosone + H2O + NAD+ = 2-dehydro-3-deoxy-D-gluconate + 2 H+ + NADH. [PMID:17175089, RHEA:67244]

3-Deoxyglucosone dehydrogenase activity is a catalytic activity that oxidizes 3-deoxyglucosone to 3-deoxy-D-erythro-hexosulose. This enzyme plays a significant role in the detoxification of 3-deoxyglucosone, a highly reactive dicarbonyl compound that forms during the Maillard reaction and is implicated in several chronic diseases, including diabetes and neurodegenerative disorders. The reaction catalyzed by 3-deoxyglucosone dehydrogenase typically involves the transfer of electrons from 3-deoxyglucosone to a suitable electron acceptor, such as NAD+ or NADP+. This oxidation process converts 3-deoxyglucosone into a less reactive form, thereby preventing its accumulation and potential damage to cellular components. 3-Deoxyglucosone dehydrogenase activity is found in a variety of organisms, including bacteria, fungi, and mammals. In humans, this activity is primarily associated with the enzyme aldose reductase, which is also involved in the reduction of glucose to sorbitol. The precise mechanism of 3-deoxyglucosone dehydrogenase activity is still under investigation, but it is believed to involve the formation of an enzyme-substrate complex that facilitates the transfer of electrons. Understanding the molecular function of 3-deoxyglucosone dehydrogenase activity is crucial for developing therapeutic strategies to target 3-deoxyglucosone-mediated oxidative stress and associated pathologies.'
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Proteins (1)

Compounds (12)