Target type: molecularfunction
Catalysis of the reaction: ITP + H2O = IDP + H+ + phosphate. [GOC:pz, PMID:16216582, RHEA:28330]
ITPase activity refers to the enzymatic hydrolysis of inositol phosphates, a critical class of signaling molecules involved in various cellular processes. Inositol phosphates, such as inositol 1,4,5-trisphosphate (IP3) and inositol hexakisphosphate (IP6), play vital roles in intracellular signaling pathways, regulating processes like calcium mobilization, membrane trafficking, and gene expression. ITPases, also known as inositol polyphosphate 5-phosphatases, specifically catalyze the removal of a phosphate group from the 5-position of inositol phosphates. This dephosphorylation reaction serves to modulate the intracellular levels of different inositol phosphate species, effectively fine-tuning their signaling activity. ITPase activity is crucial for maintaining proper cellular signaling by regulating the concentration and activity of inositol phosphates, ensuring that their signaling functions are tightly controlled and that cellular responses are appropriate to the specific stimuli.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Ectonucleoside triphosphate diphosphohydrolase 1 | An ectonucleoside triphosphate diphosphohydrolase 1 that is encoded in the genome of cow. [OMA:O18956, PRO:DNx] | Bos taurus (cattle) |
| Ectonucleoside triphosphate diphosphohydrolase 1 | An ectonucleoside triphosphate diphosphohydrolase 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49961] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| zidovudine | zidovudine : A pyrimidine 2',3'-dideoxyribonucleoside compound having a 3'-azido substituent and thymine as the nucleobase. Zidovudine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia. | azide; pyrimidine 2',3'-dideoxyribonucleoside | antimetabolite; antiviral drug; HIV-1 reverse transcriptase inhibitor |
| arl-67156 | 6-N,N-diethyl-beta,gamma-dibromomethylene-D-ATP: an inhibitor of ecto-ATPase |