adipokinetic hormone receptor activity

Definition

Target type: molecularfunction

Combining with an adipokinetic hormone to initiate a change in cell activity. Adipokinetic hormones (AKHs) are protein or peptide hormones that are important for sugar and fat homeostasis in metazoa. In insects, they mobilize sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis. [GOC:sart, PMID:11904407]

Adipokinetic hormone receptor activity is a molecular function that is associated with the binding of adipokinetic hormone (AKH) to its cognate receptor. AKH is a peptide hormone produced by the corpora cardiaca in insects, and it plays a critical role in regulating energy metabolism. When AKH binds to its receptor, it triggers a signaling cascade that leads to the mobilization of energy stores, primarily lipids, from the fat body, the insect equivalent of the liver. This mobilization of energy is important for flight, reproduction, and other energy-demanding processes. The AKH receptor is a G protein-coupled receptor (GPCR), which means that it is coupled to a G protein that relays the signal from the receptor to downstream effectors. Upon AKH binding, the receptor undergoes conformational changes that activate the G protein, leading to the production of second messengers such as cyclic AMP (cAMP). cAMP then activates protein kinase A (PKA), which phosphorylates various downstream targets involved in lipid mobilization. These targets include lipase enzymes, which break down stored triglycerides into fatty acids, and transport proteins that carry the fatty acids to other tissues. In addition to its role in energy mobilization, AKH receptor activity has also been implicated in other processes, such as growth, development, and immune responses. The precise mechanisms by which AKH receptor activity regulates these other processes are still under investigation.'
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Proteins (3)

Compounds (2)