mono-ADP-D-ribose binding

Definition

Target type: molecularfunction

Binding to monomeric ADP-D-ribose, an ADP-aldose having ribose as the aldose fragment. [GOC:mah, GOC:sart, PMID:20088964]

Mono-ADP-D-ribose (ADPR) binding is a molecular function that involves the specific and reversible interaction of a protein with the molecule ADPR. ADPR is a nucleotide derivative that plays a role in various cellular processes, including signal transduction, DNA repair, and regulation of enzyme activity. Proteins with mono-ADP-D-ribose binding activity typically possess a conserved ADPR-binding domain, which consists of a specific arrangement of amino acid residues that interact with the ADPR molecule through hydrogen bonds and electrostatic interactions. The binding of ADPR to these proteins can trigger a conformational change, leading to activation or inhibition of their activity. ADPR binding can also act as a regulatory mechanism, controlling the localization or stability of proteins. For instance, in DNA repair pathways, ADPR binding to PARP1 (poly ADP-ribose polymerase 1) activates its enzymatic activity, leading to the formation of long ADP-ribose polymers that are crucial for DNA repair. Similarly, in signal transduction, ADPR binding to certain G protein-coupled receptors can trigger downstream signaling cascades. The molecular function of mono-ADP-D-ribose binding is thus essential for maintaining cellular homeostasis and regulating diverse biological processes.'
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Proteins (1)

Compounds (11)