WD40-repeat domain binding

Definition

Target type: molecularfunction

Binding to a WD40 repeat domain of a protein. The WD40 repeat is a short structural motif of approximately 40 amino acids, often terminating in a tryptophan-aspartic acid (W-D) dipeptide. Several of these repeats are combined to form a type of protein domain called the WD domain. [GOC:yaf, InterPro:IPR017986]

WD40-repeat domains are protein modules characterized by a conserved ~40-amino acid sequence, often repeated multiple times within a single protein. These repeats form a beta-propeller structure that acts as a versatile protein-protein interaction motif. WD40-repeat domain binding, therefore, refers to the interaction of these domains with other proteins. This interaction plays a crucial role in a diverse range of cellular processes.

The molecular function of WD40-repeat domain binding is multifaceted and can be categorized into several key aspects:

* **Scaffolding and Complex Assembly:** WD40-repeat domains frequently act as scaffolds, bringing together multiple proteins to form larger protein complexes. This assembly is critical for the proper functioning of these complexes, often facilitating signal transduction pathways, transcriptional regulation, and cellular architecture.
* **Signal Transduction and Regulation:** By binding to specific proteins involved in signaling pathways, WD40-repeat domains can modulate the activity of these pathways. They can act as signal receptors, relaying information from one protein to another, or they can act as adaptors, linking different components of the pathway together.
* **Regulation of Gene Expression:** WD40-repeat domains can interact with transcription factors, co-activators, and other regulatory proteins to control gene expression. They can influence the binding of transcription factors to DNA, the recruitment of chromatin remodeling complexes, or the stability of mRNA transcripts.
* **Cellular Localization and Trafficking:** WD40-repeat domains can be involved in the localization of proteins within cells and their transport between different cellular compartments. They can interact with transport proteins, chaperones, and other factors that mediate protein trafficking.

The specific molecular function of WD40-repeat domain binding is dependent on the particular proteins involved in the interaction. The vast diversity of WD40-repeat proteins, along with the wide array of proteins they interact with, makes this interaction crucial for maintaining cellular homeostasis and orchestrating a multitude of biological processes.'
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Proteins (2)

Compounds (8)